Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:5777:inout-urn:agi-llid:2885:
Entities Grb2 ---- PTPN6
References 24
MedLine Reference 10820378:6
Sentence The results suggest that the mIgM-mediated signal strongly correlates with the formation of the CD72 / SHP-1 / Grb2 / BLNK complex.
CellType b cell
Organism Mus musculus
MedLine Reference 12468540:10194
Sentence Grb-2 interactions with semisynthetic SHP-1 proteins.
Journal J. Biol. Chem
Journal Reference v278 i7 p4668
Journal Link http://www.jbc.org/cgi/content/full/278/7/4668
MedLine Reference 10747947:10138
Sentence SHP1 associates with RAFTK and Grb2 upon MIP1eta stimulation.
Journal J. Biol. Chem
Journal Reference v275 i23 p17263
Journal Link http://www.jbc.org/cgi/content/full/275/23/17263
MedLine Reference 14551136:10023
Journal Blood
Journal Reference v103 i4 p1398
Journal Link http://www.bloodjournal.org/cgi/content/full/103/4/1398
Organism Mus musculus
MedLine Reference 9642280:10266
MedLine Reference 11390499:10159
Journal J. Immunol
Journal Reference v166 i12 p7462
Journal Link http://www.jimmunol.org/cgi/content/full/166/12/7462
Organism Mus musculus
MedLine Reference 11551923:10175
Journal J. Biol. Chem
Journal Reference v276 i47 p44315
Journal Link http://www.jbc.org/cgi/content/full/276/47/44315
Organism Mus musculus
MedLine Reference 12438221:10241
Journal Cancer Res
Journal Reference v62 i22 p6390
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/22/6390
MedLine Reference 15618472:10329
Journal Blood
Journal Reference v105 i8 p3026
Journal Link http://www.bloodjournal.org/cgi/content/full/105/8/3026
Organism Mus musculus
MedLine Reference 8626611:10199
Journal J. Biol. Chem
Journal Reference v271 i17 p10385
Journal Link http://www.jbc.org/cgi/content/full/271/17/10385
MedLine Reference 8632004:10139
Journal J. Biol. Chem
Journal Reference v271 i7 p3856
Journal Link http://www.jbc.org/cgi/content/full/271/7/3856
Organism Mus musculus
MedLine Reference 8632004
Sentence PTP1C interacts with Grb2
Source Curated
MedLine Reference 10747947:1135
Sentence SHP1 also associated with Grb2 upon MIP1eta stimulation (Fig. 2 C ).
Journal J. Biol. Chem
Journal Reference v275 i23 p17263 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/23/17263
Source Curated
MedLine Reference 9642280:1278
Sentence The association of p54 Shc, p68 Shc, Cbl, STAT3, STAT5b, SHP-1, Grb2, and paxillin with actin was induced by CSF-1.
Journal J. Biol. Chem
Journal Reference v273 i27 p17128 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/27/17128
Source Curated
MedLine Reference 10748054:1271
Sentence This may result in the recruitment of SHP-1, Shc, Grb2, and SHIP , which may become phosphorylated and further activated by Lyn bound to CD22.
Journal J. Biol. Chem
Journal Reference v275 i23 p17420 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/23/17420
Organism mouse
Source Curated
MedLine Reference 10698938:1244
Sentence However, like PTPalpha, SHP-1 is tyrosine phosphorylated in vivo at a Grb2 consensus binding site (Yeung et al. , 1992) and can bind Grb2 in vivo (Lorenz et al. , 1994) and the Src SH2 domain in vitro.
Journal EMBO
Journal Reference v19 i5 p964 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/5/964
Source Curated
CellLineName li
MedLine Reference 8632004:1031
Sentence Lastly, while a major portion of total intracellular PTP1C activity appears to be contained in Vav-PTP1C complexes, the results of this study demonstrate that PTP1C also binds to both Grb2 adaptor and mSos1 GEF proteins.
CellType t cell
Journal J. Biol. Chem
Journal Reference v271 i7 p3856 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/7/3856
Organism mouse
Source Curated
MedLine Reference 11964172
Source Curated
MedLine Reference 8626611:1199
Journal J. Biol. Chem
Journal Reference v271 i17 p10385 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/17/10385
Source Curated
CellLineName 293
MedLine Reference 12468540:1194
Journal J. Biol. Chem
Journal Reference v278 i7 p4668 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/7/4668
Source Curated
MedLine Reference 11551923:1175
CellType b cell
Journal J. Biol. Chem
Journal Reference v276 i47 p44315 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/47/44315
Organism mouse
Source Curated
MedLine Reference 12438221:1242
Journal Cancer Res
Journal Reference v62 i22 p6390 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/22/6390
Source Curated
CellLineName WEHI 231
MedLine Reference 10072516:1035
CellType b cell
Journal J. Immunol
Journal Reference v162 i5 p2717 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/5/2717
Organism mouse
Source Curated
MedLine Reference 11390499:1158
CellType b cell
Journal J. Immunol
Journal Reference v166 i12 p7462 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/12/7462
Organism C-elegans
Source Curated