Protein : MAPKAPK2
Owner Public
URN urn:agi-llid:9261
Hugo ID 6887
Connectivity 314
Name MAPKAPK2
Description MAP kinase-activated protein kinase 2
Notes mediates formation of actin stress fibers in septal neuronal cells [RGD]
RGD ID 631362
MGI ID 109298
Cell Localization Nucleus
Pathway p38 MAPK
p40 MAPK
p38 Signaling
MAPK-ERK in Growth and Differentiation
G-protein Coupled Receptor signaling
MAPK signaling
AGTR1 -> ELK1-SRF signaling pathway
Notch -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
Notch -> ELK4-SRF signaling pathway
EDG2 -> ELK4-SRF signaling pathway
AGTR2 -> CREB1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
IGF1R -> ELK1-SRF signaling pathway
IGF1R -> ELK4-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
OPRs -> ELK4-SRF signaling pathway
PLAUR -> ELK1-SRF signaling pathway
PLAUR -> ELK4-SRF signaling pathway
ENDRA -> CREB1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
PTGFR -> ELK4-SRF signaling pathway
CCKAR -> ELK1-SRF signaling pathway
SELE -> ELK4-SRF signaling pathway
CCKAR -> ELK4-SRF signaling pathway
CCKBR -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
CCKBR -> ELK4-SRF signaling pathway
PTGIR -> ELK1-SRF signaling pathway
PTGIR -> ELK4-SRF signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
CD19 -> ELK1-SRF signaling pathway
CD19 -> ELK4-SRF signaling pathway
TACR1 -> ELK1-SRF signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
TACR1 -> ELK4-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
CD28 -> CREB1 signaling pathway
INSR -> ELK4-SRF signaling pathway
TGFBR -> CREB1 signaling pathway
TGFBR -> ELK1-SRF signaling pathway
TGFBR -> ELK4-SRF signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
CD38 -> ELK1-SRF signaling pathway
CD38 -> ELK4-SRF signaling pathway
GCGR -> ELK1-SRF signaling pathway
GCGR -> ELK4-SRF signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
LEPR -> ELK1-SRF signaling pathway
CNRs -> CREB1 signaling pathway
LEPR -> ELK4-SRF signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
HTR2A -> ELK1-SRF signaling pathway
TNFRs -> CREB1 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
HTR2A -> ELK4-SRF signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
TNFRSF1A -> CREB1 signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGTR1 -> CREB1 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
p38 Signaling2
Group Kinases
MAPKKK cascade
protein amino acid phosphorylation
mRNA stabilization
cytoplasm
nucleus
signal transducer activity
nucleotide binding
ATP binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
GenBank ID NC_000001
NM_004759
NP_004750
NM_032960
NP_116584
NT_021877
NW_926794
AC_000044
AL591846
CAI13543
CAI13544
BC036060
AAH36060
BC052584
AAH52584
X75346
CAA53094
P49137
Q5SY30
Q5SY41
NC_000067
NM_008551
NP_032577
NT_078297
NW_000154
XM_977187
XP_982281
XM_977149
XP_982243
XM_977114
XP_982208
NW_001030662
AC_000023
AL513351
AI324228
AK171912
AK178022
AK188700
AK190002
AK192111
AK196663
AK198261
AK201240
AK204522
AK206582
AK208369
AK208763
AK209818
AK211802
AK214789
AK215327
AK217708
AK219589
AK219616
BC024559
AAH24559
BC063064
AAH63064
BG075933
BG088472
BG918951
X76850
CAA54183
P49138
Q8R3U8
NC_005112
NM_178102
NP_835203
NW_001084685
NW_047394
AC_000081
AY197741
AAO34665
BC062048
AAH62048
Source Curated
LocusLink ID 9261
17164
289014
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 602006
Alias mitogen-activated protein kinase-activated protein kinase 2
MK2
Rps6kc1
AA960234
MAP kinase-activated protein kinase 2
MAPKAP kinase 2
GO ID 0005524
0000166
0004674
0004871
0016740
0000165
0006468
0005634
0016301
0004672
0004713
0048255
0005737
Swiss-Prot Accession P49137
Q5SY30
Q5SY41
P49138
Q8R3U8
Unigene ID Hs.643566
Mm.221235
Rn.6276