Protein : TNFSF6


Owner	Public
URN	urn:agi-llid:356
Hugo ID	11936
Connectivity	1485
Name	TNFSF6
Description	Fas ligand (TNF superfamily, member 6)
Notes	ligand that binds the Fas receptor; plays a role in induction of apoptosis [RGD]


RGD ID	3880


MGI ID	99255


Cell Localization	Extracellular


Pathway	FAS signaling
	FasL
	Mitochondrial control of Apoptosis
	ACH-R in apoptosis
	Death receptor signaling
	AKT signaling
	p38 Signaling
	Inhibition of Apoptosis
	PTEN signaling
	Apoptosis
	MAPK signaling
	TNFRSF6 -> DDIT3 signaling pathway
	TNFRSF6 -> FOXO3A signaling pathway
	TNFRSF6 -> HSF1 signaling pathway
	TNFRSF6 -> RB1-E2F1 signaling pathway
	TNFRs -> AP-1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	TNFRs -> CREB1 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	TNFRs -> NF-kB signaling pathway
	TNFRs -> TP53 signaling pathway
	Copy of 'Apoptosis'
	Apoptosis2
	AKT signaling2
	Apoptosis2
	ACH-R in apoptosis'-2
	p38 Signaling2


Group	Ligands
	cell-cell signaling
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	apoptosis
	retinal cell programmed cell death
	induction of apoptosis
	induction of apoptosis by extracellular signals
	immune response
	extracellular region
	membrane
	integral to membrane
	integral to plasma membrane
	extracellular space
	cytokine activity
	tumor necrosis factor receptor binding


Source	Curated


OMIM ID	134638
	152700


Alias	FASL
	CD178
	CD95L
	TNFSF6
	APT1LG1
	fas ligand
	CD95 ligand
	apoptosis (APO-1) antigen ligand 1
	tumor necrosis factor (ligand) superfamily, member 6
	gld
	Fas-L
	Fas-Ligand
	Fas ligand (TNF superfamily, member 6)
	Fas antigen ligand
	generalized lymphoproliferative disease
	Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
	Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
	Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)