Protein : MAP3K1
Owner Public
URN urn:agi-llid:4214
Hugo ID 6848
Connectivity 726
Name MAP3K1
Description mitogen activated protein kinase kinase kinase 1
Notes kinase that has E3 ubiquitin ligase to mediate ubiquitination and degradation of ERK1/2 [RGD]
RGD ID 620966
MGI ID 1346872
Pathway Jnk-mapk
p38 MAPK
FAS signaling
EGF signaling
p38 Signaling
PDGF signaling
TNFR1 signaling
TNFR2 signaling
NF-kB Signaling
SAPK-JNK Signaling
Toll-Like Receptor pathway
TNFRSF6 -> DDIT3 signaling pathway
EDG2 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
TNFRSF6 -> HSF1 signaling pathway
TNFRSF6 -> RB1-E2F1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
NTRKs -> TP53 signaling pathway
ERBB2/3 -> SP1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
ENDRA -> AP-1 signaling pathway
RET -> HSF1 signaling pathway
ENDRA -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
F2R -> SP1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
PTAFR -> NF-kB signaling pathway
IL1R -> NF-kB signaling pathway
IL1R -> STAT3 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
CD28 -> ATF1 signaling pathway
CD28 -> ATF2 signaling pathway
CD28 -> CREB1 signaling pathway
Frizzled -> JUN signaling pathway
CD28 -> NF-kB signaling pathway
Frizzled -> PAX2 signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> NF-kB signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
KIT -> MITF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CNRs -> CREB1 signaling pathway
TNFRs -> AP-1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> SPI1 signaling pathway
TNFRs -> ATF2 signaling pathway
TNFRs -> CREB1 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
AGER -> CREB1 signaling pathway
NGFR -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
NGFR -> CEBPB signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
DRD2 -> CREB1 signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> SP1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
TNFRSF5 -> RB1-E2F1 signaling pathway
EDARs -> AP-1 signaling pathway
EDG2 -> ELK1-SRF signaling pathway
p38 Signaling2
Group Kinases
transforming growth factor beta receptor signaling pathway
apoptotic mitochondrial changes
regulation of cell migration
positive regulation of actin filament polymerization
protein amino acid phosphorylation
eye development (sensu Mammalia)
wound healing
cellular_component
nucleotide binding
protein binding
metal ion binding
zinc ion binding
magnesium ion binding
ATP binding
identical protein binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
MAP kinase kinase kinase activity
GenBank ID NC_000005
XM_042066
XP_042066
NT_006713
AC008937
U29671
AAB05828
AF042838
AAC97073
BX537527
Q13233
NC_000079
NM_011945
NP_036075
NT_039590
AC118704
AB014614
BAA85878
AF117340
AAD25049
AI317205
AK142245
L13103
AAA97500
U23470
AAA85038
P53349
NC_005101
NM_053887
NP_446339
NW_001084795
XM_001074670
XP_001074670
NW_047620
AC_000070
U48596
AAC52596
Q62925
Source Curated
LocusLink ID 4214
26401
116667
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600982
Alias MEKK
MEKK1
MAPKKK1
mitogen-activated protein kinase kinase kinase 1
MEK kinase 1
MAP/ERK kinase kinase 1
MAPK/ERK kinase kinase 1
mitogen activated protein kinase kinase kinase 1
MEK kinase
GO ID 0005524
0004709
0000287
0000166
0005515
0004674
0016740
0008270
0006468
0008372
0016301
0046872
0004672
0008637
0001747
0030838
0030334
0007179
0042060
0042802
Swiss-Prot Accession Q13233
P53349
Q62925
Unigene ID Hs.508461
Mm.15918
Rn.11081