DirectRegulation :


Owner	Public
URN	urn:agi-DirectRegulation:inout-urn:agi-llid:5879:out-urn:agi-llid:4214::positive
Entities	Rac1 --+> MAP3K1
References	15
Effect	positive
Connectivity	2


Sentence	Furthermore, we present evidence that MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42.
Source	Curated
Organism	yeast
MedLine Reference	8910292:8


Sentence	The small G proteins Rac1, cdc42, and Ras ( 56 ) have been identified as upstream activators of MEKK1.
Journal	Endocrinology
Source	Curated
Journal Reference	v142 i2 p887 (2001)
Journal Link	http://endo.endojournals.org/cgi/content/full/142/2/887
Organism	bovine
Organ	luteal
MedLine Reference	11159862:1283


Sentence	In addition, it has also been shown that activation of Rac 1 leads to the sequential activation of MEKK1, JNKK, and JNK (33 , 34) .
Journal	Cancer Res
Source	Curated
Journal Reference	v60 i6 p1753 (2000)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/60/6/1753
Organism	rat
MedLine Reference	10749150:1191


Sentence	Activation of MEKK1 is believed to be mediated by various small G proteins, including Ras, Rac1, and Rho ( 24 ).
CellLineName	ok
Journal	Endocrinology
Source	Curated
Journal Reference	v143 i5 p1880 (1997)
Journal Link	http://endo.endojournals.org/cgi/content/full/143/5/1880
Organism	rat
CellType	osteoblast
MedLine Reference	11956171:1038


Sentence	A further conclusion from these results is that activation of MEKK1 by Rac1 and Cdc42Hs can be a common link between the JNK/SAPK pathway and the NF-kappaB pathway.
Journal	J. Biol. Chem
Source	Curated
Journal Reference	v273 i21 p12779 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/21/12779
MedLine Reference	9582304:1197


Journal	PNAS
Source	Curated
Journal Reference	v97 i13 p7272 (2000)
Journal Link	http://www.pnas.org/cgi/content/full/97/13/7272
Organism	mouse
Tissue	epithelia
MedLine Reference	10852963:1103


Journal	Mol. Cell. Biol
Source	Curated
Journal Reference	v20 i14 p4979 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/14/4979
Organism	yeast
MedLine Reference	10848619:1282


CellLineName	ng108-15
Journal	JPET
Source	Curated
Journal Reference	v295 i3 p1094 (2000)
Journal Link	http://jpet.aspetjournals.org/cgi/content/full/295/3/1094
MedLine Reference	11082445:1174


Journal	J. Exp. Med
Source	Curated
Journal Reference	v188 i7 p1277 (1998)
Journal Link	http://www.jem.org/cgi/content/full/188/7/1277
Tissue	epithelia
MedLine Reference	9763607:1161


Journal	J. Biol. Chem
Source	Curated
Journal Reference	v276 i24 p21004 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/24/21004
MedLine Reference	11278353:1245


CellLineName	Madin Darby
Journal	J. Biol. Chem
Source	Curated
Journal Reference	v274 i23 p16604 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/23/16604
Organ	kidney
MedLine Reference	10347227:1221


Journal	J. Biol. Chem
Source	Curated
Journal Reference	v274 i18 p12605 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/18/12605
MedLine Reference	10212239:1184


Journal	Cancer Res
Source	Curated
Journal Reference	v59 i10 p2445 (1999)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/59/10/2445
MedLine Reference	10344756:1199


Journal	Mol. Endocrin
Source	Curated
Journal Reference	v14 i11 p1725 (2000)
Journal Link	http://mend.endojournals.org/cgi/content/full/14/11/1725
Organism	rat
Tissue	thyroid
MedLine Reference	11075808:1122


Source	Curated
Organism	mouse
Tissue	endoderm
MedLine Reference	15492006:10