DirectRegulation :

Owner Public
URN urn:agi-DirectRegulation:inout-urn:agi-llid:7040:out-urn:agi-llid:7048::positive
Entities TGFB1 --+> TGFBR2
References 14
Effect positive
Connectivity 2
Sentence Moreover, TGF-beta treatment induced phosphorylation of Smad2 (Smad2P) in each of these lines, except those that lacked TGF-beta type II receptors.
Source Curated
Organism mouse
MedLine Reference 11809701:5
Sentence Tranilast also prevented the PDGF-BB induced increases in TbetaRII but only partially inhibited the TGF-beta1 induced upregulation of TbetaRII.
Source Curated
Organism rat
Organ artery
Tissue smooth muscle
MedLine Reference 9622270:9
Sentence Although TGFbeta promotes the association of TbetaR-I with TbetaR-II, these receptor components have affinity for each other which can lead to their ligand-independent activation.
Source Curated
MedLine Reference 9233797:1
Sentence Repeated pulses of 200 pM of TGF-beta did not significantly induce sustained procollagen alpha 1(I) mRNA synthesis in normal fibroblasts, and this treatment did not significantly alter the characteristics of normal fibroblasts in a collagen gel. mRNA for both collagen and TGF-beta type II receptor was induced by TGF-beta in both SSc and control cells.
CellLineName SSC
Source Curated
CellType fibroblast
MedLine Reference 7807970:7
Sentence Whereas TGF-beta1 was found to induce a heteromeric complex of TbetaR-I and TbetaR-II, activin induced a heteromeric complex predominantly consisting of ActR-IB and ActR-II.
Journal Endocrinology
Source Curated
Journal Reference v140 i9 p4300 (1999)
Journal Link http://endo.endojournals.org/cgi/content/full/140/9/4300
Organism pig
Tissue follicle
MedLine Reference 10465304:1238
CellLineName ishikawa
Source Curated
MedLine Reference 11330966:7
Source Curated
Organism mouse
MedLine Reference 9856985:2
CellLineName GOBLET
Source Curated
Organism mouse
MedLine Reference 9950213:7
Source Curated
Organism bovine
Tissue bone
MedLine Reference 8662721:6
Source Curated
CellType fibroblast
Organ skin
MedLine Reference 14500687:8
Source Curated
Organism mouse
Tissue mammary gland
MedLine Reference 15708558:1
Source Curated
Tissue mesenchyma
MedLine Reference 12038632:8
Source Curated
Organism mouse
Organ liver
MedLine Reference 11290556:6
Source Curated
Organism rat
Tissue epithelia
MedLine Reference 11381048:11