Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:998:inout-urn:agi-go:0003930:
Entities CDC42 ---- RAS small monomeric GTPase
References 13
MedLine Reference 10840034:3
Sentence We show that GDP- but not GTP-bound Cdc42 prevents Ras-GRF recruitment to the membrane and activation of Ras/MAPK, although no direct association of Ras-GRF with Cdc42 was detected.
Organism Mus musculus
MedLine Reference 12764130:0
Sentence The p21-activated kinase (PAK) homolog, Shk1, is a critical component of a multifunctional Ras/Cdc42/PAK complex required for viability, polarized growth and cell shape, and sexual differentiation in the fission yeast, Schizosaccharomyces pombe.
MedLine Reference 9834070:10277
Sentence In addition, the interaction between Vav, PI3K, PKC, Ras, and Rac/cdc42 is likely to be complex ( 20 , 60 ).
Journal J. Immunol
Journal Reference v161 i11 p5901
Journal Link http://www.jimmunol.org/cgi/content/full/161/11/5901
MedLine Reference 11782455:10132
Journal J. Biol. Chem
Journal Reference v277 i12 p10283
Journal Link http://www.jbc.org/cgi/content/full/277/12/10283
Organism Mus musculus
MedLine Reference 11285260:10235
Journal J. Biol. Chem
Journal Reference v276 i24 p21878
Journal Link http://www.jbc.org/cgi/content/full/276/24/21878
MedLine Reference 9121475:1
Sentence Like Ras, the Rho proteins (which include Rho, Rac, and CDC42) interact directly with protein kinases, which are likely to serve as downstream effector targets of the activated GTPase.
Organism mouse
Source Curated
MedLine Reference 11285260:1229
Sentence Our previous results ( 17 ) do not indicate a direct physical interaction between Ras-GRF and Cdc42, at least in vitro .
Journal J. Biol. Chem
Journal Reference v276 i24 p21878 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/24/21878
Source Curated
MedLine Reference 11748228:1243
Sentence Other monomeric GTPases, including Ras, Rac, and cdc42, have been shown to interact with PI3K ( 27-29 ).
Journal J. Biol. Chem
Journal Reference v277 i10 p7816 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/10/7816
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 10840034:1016
Sentence We show that GDP- but not GTP-bound Cdc42 prevents Ras-GRF recruitment to the membrane and activation of Ras/MAPK, although no direct association of Ras-GRF with Cdc42 was detected.
Journal J. Biol. Chem
Journal Reference v275 i34 p26441 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/34/26441
Organism mouse
Source Curated
MedLine Reference 10748040:1251
Sentence These include SH2 and SH3 domains, proline-rich domains, a Ras binding domain, and a Rho-GTPase-activating protein homology region that can bind Cdc42 or Rac in a GTP-dependent manner ( 51 ).
Journal J. Biol. Chem
Journal Reference v275 i22 p16933 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/22/16933
Organism mouse
Source Curated
CellLineName 293T
MedLine Reference 10733591:1126
Organ brain
Journal Mol. Cell. Biol
Journal Reference v20 i8 p2880 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/8/2880
Organism mouse
Source Curated
MedLine Reference 9834070:1274
CellType b cell
Journal J. Immunol
Journal Reference v161 i11 p5901 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/11/5901
Source Curated
MedLine Reference 12764130:1012
Journal J. Biol. Chem
Journal Reference v278 i32 p30074 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/32/30074
Organism yeast
Source Curated