Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-go:0008433:inout-urn:agi-go:0003930:
Entities GEF ---- RAS small monomeric GTPase
References 53
MedLine Reference 8289792:1
Sentence We have used the growth-inhibitory phenotype of Ras(17N) to characterize two aspects of Ras interaction with GEFs.
Organism Mus musculus
MedLine Reference 9038368:2
Sentence We show here that the substitution N123I which weakens the guanine nucleotide binding also promotes ras-GEF interaction.
MedLine Reference 12740440:3
Sentence Ras GEFs bind to Ras and facilitate GDP release, followed by GTP incorporation and Ras activation.
MedLine Reference 9856997:10199
Organism Mus musculus
MedLine Reference 11560935:10054
Journal J. Biol. Chem
Journal Reference v276 i50 p47248
Journal Link http://www.jbc.org/cgi/content/full/276/50/47248
MedLine Reference 9407081:10214
Journal J. Biol. Chem
Journal Reference v272 i52 p33001
Journal Link http://www.jbc.org/cgi/content/full/272/52/33001
Organism Rattus norvegicus
MedLine Reference 12874025:10234
Journal Cancer Res
Journal Reference v63 i14 p4188
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/14/4188
Organism Mus musculus
MedLine Reference 15197243:10027
Journal Cell Sci
Journal Reference v117 i14 p2879
Journal Link http://jcs.biologists.org/cgi/content/full/117/14/2879
MedLine Reference 10666033:10040
Journal Cell Phys
Journal Reference v278 i2 pC372
Journal Link http://ajpcell.physiology.org/cgi/content/full/278/2/C372
Organism Mus musculus
MedLine Reference 9819430:10304
MedLine Reference 15878843:10259
Journal J. Biol. Chem
Journal Reference v280 i27 p25697
Journal Link http://www.jbc.org/cgi/content/full/280/27/25697
Organism Mus musculus
MedLine Reference 10815806:3
Organism Mus musculus
MedLine Reference 8626650:0
Organism Mus musculus
MedLine Reference 16325815:2
MedLine Reference 8524097:2
MedLine Reference 15034142:1
MedLine Reference 101001078:11149
Journal Cell
Journal Reference v92 i3 p415
Journal Link http://www.cell.com/cgi/content/full/92/3/415
MedLine Reference 8663268:10020
Journal J. Biol. Chem
Journal Reference v271 i29 p17234
Journal Link http://www.jbc.org/cgi/content/full/271/29/17234
Organism Mus musculus
MedLine Reference 11333268:10270
Journal J. Biol. Chem
Journal Reference v276 i29 p27629
Journal Link http://www.jbc.org/cgi/content/full/276/29/27629
MedLine Reference 9632667:10201
MedLine Reference 10747847:10120
Journal J. Biol. Chem
Journal Reference v275 i18 p13406
Journal Link http://www.jbc.org/cgi/content/full/275/18/13406
MedLine Reference 10934204:10170
Journal J. Biol. Chem
Journal Reference v275 i45 p34901
Journal Link http://www.jbc.org/cgi/content/full/275/45/34901
MedLine Reference 7499262:10175
Journal J. Biol. Chem
Journal Reference v270 i46 p27880
Journal Link http://www.jbc.org/cgi/content/full/270/46/27880
Organism Mus musculus
MedLine Reference 9582122:10050
Journal Science
Journal Reference v280 i5366 p1082
Journal Link http://www.sciencemag.org/cgi/content/full/280/5366/1082
Organism Rattus norvegicus
MedLine Reference 10196191:10141
Journal J. Biol. Chem
Journal Reference v274 i16 p11078
Journal Link http://www.jbc.org/cgi/content/full/274/16/11078
Organism Mus musculus
MedLine Reference 9312123:10165
Journal J. Biol. Chem
Journal Reference v272 i40 p25128
Journal Link http://www.jbc.org/cgi/content/full/272/40/25128
Organism Mus musculus
MedLine Reference 10747953:10225
Journal J. Biol. Chem
Journal Reference v275 i23 p17754
Journal Link http://www.jbc.org/cgi/content/full/275/23/17754
MedLine Reference 10593969:10200
Journal J. Biol. Chem
Journal Reference v274 i51 p36656
Journal Link http://www.jbc.org/cgi/content/full/274/51/36656
Organism Mus musculus
MedLine Reference 10961860:1111
Sentence GTP-Ras also binds and activates PI-3K and Ral-GEF.
Journal Blood
Journal Reference v96 i5 p1655 (2000)
Journal Link http://www.bloodjournal.org/cgi/content/full/96/5/1655
Source Curated
MedLine Reference 10593969:1192
Sentence The interaction between GEF and ras has to be sufficiently strong to displace the bound nucleotide and weak enough to allow entry of the nucleotide and disruption of the binary GEF???·ras complex.
Journal J. Biol. Chem
Journal Reference v274 i51 p36656 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/51/36656
Organism mouse
Source Curated
CellLineName CA
MedLine Reference 11560935:1052
Sentence Structure/function studies based on mutagenesis have identified three regions of Ras that interact with GEFs : the switch 1 region (aa 25-40), the switch 2 region (aa 57-65), and alpha-helix 3 (aa 92-104) plus loop 7 (aa 105-109) (25-36).
Journal J. Biol. Chem
Journal Reference v276 i50 p47248 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/50/47248
Organism drosophila
Source Curated
MedLine Reference 7499262:1175
Sentence A dominant-negative mutant Ras(S17N), which binds to Ras-GEFs tightly to prevent its action toward endogenous Ras, has been utilized widely to evaluate whether Ras is essential for a particular signal transduction pathway (Feig and Cooper, 1988).
Tissue hematological
Journal J. Biol. Chem
Journal Reference v270 i46 p27880 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/46/27880
Organism mouse
Source Curated
MedLine Reference 10747953:1222
Sentence INTRODUCTION EXPERIMENTAL PROCEDURES RESULTS DISCUSSION REFERENCES The reconstituted cell-free system used in this study reproduces in vitro the physiological conditions of the interaction between Ras and GEFs or adenylyl cyclase as cell membrane-bound components.
Journal J. Biol. Chem
Journal Reference v275 i23 p17754 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/23/17754
Organism yeast
Source Curated
CellType neural
Journal J. Cell Biol
Journal Reference v163 i5 p1067 (2003)
Journal Link http://www.jcb.org/cgi/content/full/163/5/1067
Source Curated
CellLineName COS-7
CellType neural
Journal J. Cell Biol
Journal Reference v163 i5 p1067 (2003)
Journal Link http://www.jcb.org/cgi/content/full/163/5/1067
Source Curated
CellLineName COS-7
MedLine Reference 9660763:1039
Journal J. Biol. Chem
Journal Reference v273 i29 p18067 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/29/18067
Source Curated
MedLine Reference 9856997:1199
Journal J. Biol. Chem
Journal Reference v273 i52 p34737 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/52/34737
Organism mouse
Source Curated
MedLine Reference 9632667:1201
Journal J. Biol. Chem
Journal Reference v273 i26 p16134 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/26/16134
Source Curated
MedLine Reference 9407081:1214
Journal J. Biol. Chem
Journal Reference v272 i52 p33001 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/52/33001
Organism rat
Source Curated
MedLine Reference 9312123:1165
Journal J. Biol. Chem
Journal Reference v272 i40 p25128 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/25128
Organism mouse
Source Curated
MedLine Reference 8663268:1020
Organ brain
Journal J. Biol. Chem
Journal Reference v271 i29 p17234 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/29/17234
Organism mouse
Source Curated
MedLine Reference 8626650:1038
Journal J. Biol. Chem
Journal Reference v271 i19 p11076 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/19/11076
Organism mouse
Source Curated
CellLineName NIH 3T3
MedLine Reference 12134164:5
Organism mouse
Source Curated
MedLine Reference 9219684:1030
Journal Science
Journal Reference v277 i5324 p333 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/277/5324/333
Source Curated
MedLine Reference 9582122:1050
Organ brain
Journal Science
Journal Reference v280 i5366 p1082 (1998)
Journal Link http://www.sciencemag.org/cgi/content/full/280/5366/1082
Organism rat
Source Curated
MedLine Reference 11333268:1269
Journal J. Biol. Chem
Journal Reference v276 i29 p27629 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/29/27629
Source Curated
MedLine Reference 10934204:1146
Journal J. Biol. Chem
Journal Reference v275 i45 p34901 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/45/34901
Source Curated
CellLineName 293T
MedLine Reference 10747847:1121
Journal J. Biol. Chem
Journal Reference v275 i18 p13406 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/18/13406
Source Curated
CellLineName 293T
Journal Cell
Journal Reference v92 i3 p415 (1998)
Journal Link http://www.cell.com/cgi/content/full/92/3/415
Source Curated
Journal Cell
Journal Reference v92 i3 p415 (1998)
Journal Link http://www.cell.com/cgi/content/full/92/3/415
Source Curated
MedLine Reference 10666033:1040
Journal Cell Phys
Journal Reference v278 i2 pC372 (2000)
Journal Link http://ajpcell.physiology.org/cgi/content/full/278/2/C372
Organism drosophila
Source Curated
MedLine Reference 11714636:1017
Journal Cell Growth and Diff
Journal Reference v12 i11 p551 (2001)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/12/11/551
Organism mouse
Source Curated
MedLine Reference 12874025:1234
Journal Cancer Res
Journal Reference v63 i14 p4188 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/14/4188
Organism mouse
Source Curated