Protein HES1

Owner Public
URN urn:agi-llid:3280
Notes HES-1 is an upstream negative regulator of REST expression. HES-1 is an upstream negative regulator of REST expression. HES-1 preserves the long-term reconstituting hematopoietic activity of 34-KSL stem cells ex vivo. Hes1 transcription repression activity is inhibited by Hes6. IkappaBalpha is recruited to the promoter regions of the Notch-target gene, hes1. Notch1 inhibits the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through HES1. These results indicate that the molecular association between HES1-, HEY2- and SIRT1-related proteins is conserved among metazoans, from Drosophila to human, and suggest that the Sir2-bHLH interaction also plays important roles in human cells. This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. The estrogen receptor and AhR signaling pathways regulate HES-1, but with opposing effects, suggests the existence of a new pathway by which AhR represses E2-signaling.
Connectivity 1
Name HES1
Description hairy and enhancer of split 1

Cell Localization Nucleus

Mouse chromosome position 16 27.0 cM

OMIM ID 139605

GO ID 0003677
0016564
0042668
0007155
0045165
0048469
0001889
0030324
0045608
0045665
0000122
0007399
0021983
0008284
0048505
0006355
0005737
0005634
0030528
0042491
0045596
0045449
0006350

Pathway Notch -> HES/HEY signaling

Hugo ID 5192

Rat chromosome position 11q22

Human chromosome position 3q28-q29

Swiss-Prot Accession Q6FHB2
Q14469
Q04666
Q8IXV0
P35428
Q9BS99

GenBank ID NC_000003
NM_005524
NP_005515
NT_005612
NW_921807
NW_001838884
AC_000046
AC_000135
AC080129
CH471052
EAW78058
L19314
AAA65220
AF264785
AAF73060
AK000415
BAA91149
BC005178
AAH05178
BC039152
AAH39152
CR541843
CAG46641
CR609648
CR610974
CR616000
Q14469
Q6FHB2
Q8IXV0
Q9BS99
BC156516
AAI56517
DQ891328
ABM82254
DQ893354
ABM84280
DQ896673
ABM87672
NC_000082
NM_008235
NP_032261
NT_039624
CH466521
EDK97718
CT030736
D16464
BAA03931
AK132536
BAE21226
AK133538
BAE21713
BC018375
AAH18375
BC051428
AAH51428
P35428
Q3UZZ2
Q3V1C5
NC_005110
NM_024360
NP_077336
NW_001084663
NW_047356
AC_000079
CH473999
EDL78150
EDL78151
BC061730
AAH61730
D13417
BAA02682
L04527
AAA41307
Q04666
XM_914035
XP_001000689
NW_000107
AC_000038
NW_001030584
XM_001000689

LocusLink ID 3280
15205
29577

Unigene ID Hs.250666
Mm.390859
Rn.19727
Mm.327031

KEGG ID hsa:3280
mmu:15205
rno:29577

Alias HHL
HRY
HES-1
FLJ20408
hairy and enhancer of split 1
hairy homolog
transcription factor HES-1
hairy homolog (Drosophila)
Hes1
Hairy and enhancer of split I
Hairy- like
Hes I
hairy and enhancer of split 1, (Drosophila)
Transcription factor HES I

Homologene ID 38067

Organism Homo sapiens
Mus musculus
Rattus norvegicus

MGI ID 104853

RGD ID 62081