Protein : MAP3K7


Owner	Public
URN	urn:agi-llid:6885
Hugo ID	6859
Connectivity	40
Name	MAP3K7
Description	mitogen activated protein kinase kinase kinase 7 (predicted)
Notes	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.


RGD ID	1309438


MGI ID	1346877


Pathway	Jnk-mapk
	p38 MAPK
	TGF-beta signaling
	Wnt signaling
	FAS signaling
	p38 Signaling
	TNFR1 signaling
	NF-kB Signaling
	SAPK-JNK Signaling
	Toll-Like Receptor pathway
	MAPK signaling
	B-cell receptor -> NF-kB signaling pathway
	IL1R -> NF-kB signaling pathway
	T-cell receptor -> NF-kB signaling pathway
	CD22/72 -> NF-kB signaling pathway
	TLR1/2 -> NF-kB signaling pathway
	TLR2/4/5/7/9 -> AP-1 signaling pathway
	TLR2/6 -> AP-1 signaling pathway
	TLR2/6 -> NF-kB signaling pathway
	TLR4/5/7/9 -> NF-kB signaling pathway
	DDR1 -> NF-kB signaling pathway
	EDARs -> LEF1 signaling pathway


Group	Kinases
	transforming growth factor beta receptor signaling pathway
	MAPKKK cascade
	I-kappaB phosphorylation
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	negative regulation of apoptosis
	protein amino acid phosphorylation
	neural tube formation
	angiogenesis
	nucleotide binding
	protein binding
	metal ion binding
	magnesium ion binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	MAP kinase kinase kinase activity


Source	Curated


OMIM ID	602614


Alias	TAK1
	TGF1a
	mitogen-activated protein kinase kinase kinase 7
	TGF-beta activated kinase 1
	transforming growth factor-beta-activated kinase 1
	C87327
	B430101B05
	mitogen activated protein kinase kinase kinase 7
	TGF-beta-activated kinase 1
	Map3k7
	mitogen activated protein kinase kinase kinase 7 (predicted)