Protein : TNFAIP3
Owner Public
URN urn:agi-llid:7128
Hugo ID 11896
Connectivity 24
Name TNFAIP3
Description tumor necrosis factor, alpha-induced protein 3
Notes This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.
MGI ID 1196377
Cell Localization Nucleus
Pathway TNFR2 signaling
NF-kB Signaling
Group Proteases
negative regulation of I-kappaB kinase-NF-kappaB cascade
apoptosis
anti-apoptosis
ubiquitin cycle
cytoplasm
nucleus
protein binding
metal ion binding
zinc ion binding
DNA binding
hydrolase activity
peptidase activity
cysteine-type peptidase activity
GenBank ID NC_000006
NM_006290
NP_006281
NT_025741
NW_923184
AC_000049
AL357060
CAH72934
CAH72935
CAH72936
CAH72937
AY248754
AAO61093
AL157444
CAB75664
AY820830
AAV71149
BC041790
BC064689
AAH64689
BC113871
AAI13872
BC114480
AAI14481
BQ002744
M59465
AAA51550
P21580
Q5PY18
Q5VXQ7
Q5VXQ8
Q5VXQ9
Q5VXR0
Q6P281
Q9NSR6
NC_000076
NM_009397
NP_033423
NT_039492
NW_000023
NW_001030408
AC_000032
AC102657
AK088297
BAC40267
AK151921
BAE30799
AK153238
BAE31830
AK171326
BAE42395
AK172529
BAE43051
BC050259
AAH50259
BC054806
AAH54806
BC060221
AAH60221
BM241351
CT010397
CAJ18603
U19463
AAC52153
Q60769
Source Curated
LocusLink ID 7128
21929
Organism Homo sapiens
Mus musculus
OMIM ID 191163
Alias A20
OTUD7C
TNFA1P2
MGC104522
MGC138687
MGC138688
tumor necrosis factor, alpha-induced protein 3
tumor necrosis factor inducible protein A20
Tnfip3
zinc finger protein A20
tumor necrosis factor induced protein 3
GO ID 0003677
0008234
0046872
0005515
0008270
0006916
0006915
0043124
0006512
0005634
0016787
0008233
0005737
Swiss-Prot Accession P21580
Q5PY18
Q5VXQ7
Q5VXQ8
Q5VXQ9
Q5VXR0
Q6P281
Q9NSR6
Q60769
Unigene ID Hs.591338
Mm.116683