Expression :

Owner Public
URN urn:agi-Expression:inout-urn:agi-complex:3000097:out-urn:agi-go:0005194::unknown
Entities Nuclear factor NF kappa B ---> cell adhesion molecule activity
References 5
Connectivity 2
Effect unknown
MedLine Reference 9824778:0
Sentence Nuclear factor kappa B (NF-kappa B) is an ubiquitous rapid response transcription factor in cells involved in immune and inflammatory reactions, and exerts its effect by expressing cytokines, chemokines, cell adhesion molecules, growth factors, and immunoreceptors.
Source Curated
MedLine Reference 10224110:1032
Sentence NF-kappaB regulates the expression of many biologically important genes such as those encoding inflammatory cytokines, interferons, growth factors, cell adhesion molecules, and viruses.
CellType tumor model
Journal J. Biol. Chem
Journal Reference v274 i19 p13451 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/19/13451
Organ breast
Source Curated
MedLine Reference 10953045:1020
Sentence NF-kappaB has been shown to be essential for the expression of cell adhesion molecules as demonstrated by deletion mutagenesis, gel-retardation assays, Western blots, and DNA transfection experiments (Iademarco et al., 1992 ; Hou et al., 1994 ; Schindler and Baichwal, 1994 ; Collins et al., 1995 ).
Journal Mol. Pharm
Journal Reference v58 i3 p526 (2000)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/58/3/526
Source Curated
MedLine Reference 12649352:1019
Sentence The transcription factor nuclear factor-kappaB (NF-kappaB) regulates expression of proinflammatory cytokines such as tumor necrosis factor and interleukins, cell adhesion molecules, and the inducible enzymes such as nitric oxide synthase, COXs, and manganese superoxide dismutase (Baeuerle and Baltimore, 1996 ; O'Neill and Kaltschmidt, 1997 ) and modulates degeneration of neurons and non-neuronal cells (Beg and Baltimore, 1996 ; Scatena et al., 1998 ).
CellType neural
Journal JPET
Journal Reference v305 i1 p48 (2003)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/305/1/48
Organism mouse
Source Curated
MedLine Reference 2367316723
Sentence NF-kappaB regulates the expression of various cytokines, cell adhesion molecules, and inflammatory mediators that are important for coordinating cellular responses to stress, infection, and injury (Ghosh et al., 1998 ).
CellType neural
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00546.x/full/
Tissue nerve
Source Curated