Expression :

Owner Public
URN urn:agi-Expression:inout-urn:agi-complex:3000097:out-urn:agi-llid:7124::positive
Entities Nuclear factor NF kappa B --+> TNF
References 41
Connectivity 2
Effect positive
MedLine Reference 9227470:0
Sentence A redox-sensitive nuclear factor, NF-kappa B, induces transcription of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in macrophages.
CellType macrophage
Organism rat
Source Curated
MedLine Reference 9181468:0
Sentence In macrophages, nuclear factor kappa B (NF-kappa B) has been shown to transactivate the promoters of many cytokines, including tumor necrosis factor-alpha (TNF-alpha).
CellType macrophage
Organism mouse
Source Curated
MedLine Reference 10504393:1228
Sentence Activation of NF-kappaB could increase TNF-alpha expression in the liver ( 40 ).
Journal Eur. J. Biochem
Journal Reference v265 i2 p619 (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/265/2/619
Organ liver
Source Curated
MedLine Reference 9224203:1109
Sentence NF-kappaB activation enhances the transcription of TNF-alpha and IL-1eta, and both of these cytokines are in turn known to activate NF-kappaB.
Journal AJRCMB
Journal Reference v17 i1 p3 (1997)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/17/1/3
Organism mouse
Source Curated
MedLine Reference 11259437:1161
Sentence As this time course precedes the time course of the gene promoter activation (Fig. 2 B ), the results indicate that NF-kappaB might be responsible for activation of the TNF-alpha gene promoter.
Journal J. Biol. Chem
Journal Reference v276 i23 p20781 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/23/20781
Organism mouse
Source Curated
MedLine Reference 10837498:1388
CellType monocyte
Journal J. Biol. Chem
Journal Reference v275 i23 p17728 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/23/17728
Source Curated
MedLine Reference 10559228:1204
CellType t cell
Journal J. Biol. Chem
Journal Reference v274 i47 p33455 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/47/33455
Source Curated
Journal Cell
Journal Reference v103 i7 p993 (2000)
Journal Link http://www.cell.com/cgi/content/full/103/7/993
Source Curated
MedLine Reference 12538767:1029
Journal Cell Sci
Journal Reference v116 i4 p665 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/116/4/665
Source Curated
MedLine Reference 12154067:1220
CellType macrophage
Journal Cell Sci
Journal Reference v115 i17 p3357 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/17/3357
Tissue epithelia
Source Curated
MedLine Reference 12151344:1192
Journal Carcinogenesis
Journal Reference v23 i8 p1273 (2002)
Journal Link http://carcin.oupjournals.org/cgi/content/full/23/8/1273
Tissue blood
Source Curated
MedLine Reference 10617597:1014
CellType macrophage
Journal J. Biol. Chem
Journal Reference v275 i1 p141 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/1/141
Organism mouse
Source Curated
MedLine Reference 10206979:1012
CellType macrophage
Journal J. Biol. Chem
Journal Reference v274 i17 p11667 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/17/11667
Organism mouse
Source Curated
MedLine Reference 10433212:1195
CellType macrophage
Journal Endocrinology
Journal Reference v140 i8 p3562 (1999)
Journal Link http://endo.endojournals.org/cgi/content/full/140/8/3562
Organism rat
Source Curated
MedLine Reference 12176740:1144
Journal Cell Phys
Journal Reference v283 i3 pC831 (2002)
Journal Link http://ajpcell.physiology.org/cgi/content/full/283/3/C831
Organism mouse
Source Curated
MedLine Reference 10878378:0
Organism mouse
Source Curated
MedLine Reference 11602691:1115
CellType t cell
Journal JPET
Journal Reference v299 i2 p753 (2001)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/299/2/753
Source Curated
MedLine Reference 11316802:1093
Journal J. Biol. Chem
Journal Reference v276 i28 p25692 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/25692
Tissue microglia
Source Curated
MedLine Reference 11262403:1052
Journal J. Biol. Chem
Journal Reference v276 i23 p19889 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/23/19889
Organ intestine
Source Curated
MedLine Reference 11118442:1180
Journal J. Biol. Chem
Journal Reference v276 i12 p8918 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/12/8918
Source Curated
MedLine Reference 11367517:4
CellType peripheral blood mononuclear cell
CellLineName PBMC
Source Curated
MedLine Reference 12871593:3
Tissue microglia
Organism mouse
Source Curated
MedLine Reference 12161100:1
CellType MAST
Organism plant
CellLineName AG
Source Curated
MedLine Reference 11312646:3
CellType macrophage
Organism mouse
Source Curated
MedLine Reference 11179036:0
Organism mouse
Organ heart
Source Curated
MedLine Reference 9366558:2
CellType neutrophil
Tissue pulmonary
Organism rat
Organ lung
Source Curated
MedLine Reference 9394802:9
CellType macrophage
Organism mouse
CellLineName J774 A.1
Source Curated
MedLine Reference 7729908:3
CellType macrophage
Organism mouse
Source Curated
MedLine Reference 10648713:1300
Journal J. Neurosci
Journal Reference v20 i3 p1073 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/3/1073
Organism rat
Source Curated
MedLine Reference 9830030:1043
CellType lymphocyte
Journal J. Biol. Chem
Journal Reference v273 i49 p32833 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/49/32833
Organism mouse
Organ spleen
Source Curated
MedLine Reference 9162077:1019
CellType macrophage
Journal J. Biol. Chem
Journal Reference v272 i22 p14394 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/22/14394
Organism mouse
Source Curated
MedLine Reference 11410599:1236
CellType macrophage
Journal J. Biol. Chem
Journal Reference v276 i34 p32008 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/32008
Organism mouse
Source Curated
MedLine Reference 15144120:4
Source Curated
MedLine Reference 14963056:1
Source Curated
MedLine Reference 10353600:7
CellLineName MCF7 A/Z
Source Curated
MedLine Reference 11158257:6
Tissue vascular
Organism rat
Organ brain
Source Curated
MedLine Reference 9688686:1173
CellType macrophage
Journal Reg. Int. Comp. Phys
Journal Reference v275 i2 pR502 (1998)
Journal Link http://ajpregu.physiology.org/cgi/content/full/275/2/R502
Organism rat
Source Curated
MedLine Reference 12869625:1151
CellType macrophage
Journal Mol. Pharm
Journal Reference v64 i2 p211 (2003)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/64/2/211
Organism mouse
Source Curated
MedLine Reference 15793859:8
Organism rat
Source Curated
MedLine Reference 15239102:5
Organism mouse
Organ liver
Source Curated
MedLine Reference 12975476:9
CellType osteoclast
Tissue bone
Organism mouse
Source Curated