Regulation :

Effect positive
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:93572-42-0:out-urn:agi-llid:7099::positive:phosphorylation
Entities LPS --+> TLR4
References 43
Connectivity 2
MedLine Reference 12904319:0
Sentence Toll-like receptor 4 (TLR-4) is a critical mediator of the cellular response to lipopolysaccharide.
Organism Mus musculus
MedLine Reference 16078575:7
Sentence The expressions of TLR2, 3, 4 on DC change significantly after being stimulated by LPS.
CellType monocyte
CellLineName DC
MedLine Reference 16263085:5
Sentence Involvement of caveolae in LPS-induced TLR4 endocytosis was further confirmed by immunoprecipitation.
MedLine Reference 16387633:3
Tissue microglia
Organ brain
MedLine Reference 15670831:2
MedLine Reference 16754725:2
MedLine Reference 12495941:5
Tissue blood
CellType monocyte
MedLine Reference 14766898:6
Tissue endothelial
MedLine Reference 14976215:7
Organism Mus musculus
CellType macrophage
MedLine Reference 15829295:0
Organism Mus musculus
MedLine Reference 16525587:0
Organ immunologic
MedLine Reference 15475494:9
Organ lung
Organism Mus musculus
MedLine Reference 15618008:5
CellType macrophage
MedLine Reference 16140274:0
Organism Mus musculus
MedLine Reference 16785024:1
Organism Mus musculus
MedLine Reference 16982271:4
CellLineName MDPC-23
MedLine Reference 14699116:10199
Journal J. Biol. Chem
Journal Reference v279 i11 p10564
Journal Link http://www.jbc.org/cgi/content/full/279/11/10564
MedLine Reference 15632166:10242
Journal J. Biol. Chem
Journal Reference v280 i10 p9482
Journal Link http://www.jbc.org/cgi/content/full/280/10/9482
Organism Mus musculus
MedLine Reference 14568981:10217
Journal J. Exp. Med
Journal Reference v198 i8 p1225
Journal Link http://www.jem.org/cgi/content/full/198/8/1225
Organism Mus musculus
MedLine Reference 12611905:10681
Journal Lipid Res
Journal Reference v44 i5 p994
Journal Link http://www.jlr.org/cgi/content/full/44/5/994
Organism Mus musculus
MedLine Reference 14657203:10457
Journal Lipid Res
Journal Reference v45 i3 p536
Journal Link http://www.jlr.org/cgi/content/full/45/3/536
MedLine Reference 11801529:10373
Journal Cell Growth and Diff
Journal Reference v13 i1 p27
Journal Link http://cgd.aacrjournals.org/cgi/content/full/13/1/27
MedLine Reference 15890981:10273
Journal Circulation Res
Journal Reference v96 i9 p939
Journal Link http://circres.ahajournals.org/cgi/content/full/96/9/939
MedLine Reference 15100092:10342
Journal Endocrin. Metabol
Journal Reference v287 i2 p331
Journal Link http://ajpendo.physiology.org/cgi/content/full/287/2/E331
Organism Mus musculus
MedLine Reference 15142865:10182
Journal AJRCMB
Journal Reference v31 i3 p330
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/31/3/330
MedLine Reference 15514106:10193
Journal Reg.Int.Comp.Phys
Journal Reference v288 i3 p600
Journal Link http://ajpregu.physiology.org/cgi/content/full/288/3/R600
Organism Mus musculus
MedLine Reference 15753091:10220
Journal J. Biol. Chem
Journal Reference v280 i19 p19021
Journal Link http://www.jbc.org/cgi/content/full/280/19/19021
MedLine Reference 12655047:10042
Journal PNAS
Journal Reference v100 i7 p4203
Journal Link http://www.pnas.org/cgi/content/full/100/7/4203
Organism Mus musculus
MedLine Reference 12686512:10289
Journal Cell Phys
Journal Reference v285 i2 pC399
Journal Link http://ajpcell.physiology.org/cgi/content/full/285/2/C399
Organism Mus musculus
MedLine Reference 11502220:10124
Journal Eur. J. Biochem
Journal Reference v268 i16 p4580
Journal Link http://www.ejbiochem.org/cgi/content/full/268/16/4580
MedLine Reference 15308667:10351
Journal J. Biol. Chem
Journal Reference v279 i43 p45279
Journal Link http://www.jbc.org/cgi/content/full/279/43/45279
MedLine Reference 16464966:6
Tissue epithelia
Organ lung
Organism Mus musculus
MedLine Reference 106100160:11201
Journal EMBO
Journal Reference v23 i7 p7600170
Journal Link http://www.nature.com/emboj/journal/v23/n7/full/7600170a.html
MedLine Reference 15866876:10201
Journal J. Biol. Chem
Journal Reference v280 i26 p25233
Journal Link http://www.jbc.org/cgi/content/full/280/26/25233
Organism Mus musculus
MedLine Reference 11518685:10196
Journal Gastr. Liver Phys
Journal Reference v281 i3 pG726
Journal Link http://ajpgi.physiology.org/cgi/content/full/281/3/G726
MedLine Reference 12686512:1177
Sentence LPS induces phosphorylation of both JNK and JAK2 via Toll-like receptor (TLR)4.
Journal Cell Phys
Journal Reference v285 i2 pC399 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/285/2/C399
Organism mouse
Source Curated
MedLine Reference 10561604:1195
Sentence In phagocytes, LPS stimulates TLR4 signal transduction molecules such as myeloid differentiation factor 88 (MyD88), IL-1R-associated kinase, TNF receptor-associated factor 6, and TAK1 ( 14 ).
Journal Eur. J. Biochem
Journal Reference v266 i2 p608 (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/266/2/608
Organism plant
Source Curated
CellType phagocyte
MedLine Reference 15773898:0
Source Curated
CellType macrophage
MedLine Reference 12655047:1042
Tissue epithelia
Journal PNAS
Journal Reference v100 i7 p4203 (1996)
Journal Link http://www.pnas.org/cgi/content/full/100/7/4203
Organ renal
Organism drosophila
Source Curated
Journal J. Exp. Med
Journal Reference v198 i8 p1225 (2003)
Journal Link http://www.jem.org/cgi/content/full/198/8/1225
Source Curated
MedLine Reference 12611905:1679
Journal Lipid Res
Journal Reference v44 i5 p994 (2003)
Journal Link http://www.jlr.org/cgi/content/full/44/5/994
Organism mouse
Source Curated
CellType adipocyte
Tissue epithelia
Journal J. Exp. Med
Journal Reference v198 i8 p1225 (2003)
Journal Link http://www.jem.org/cgi/content/full/198/8/1225
Organ gastric
Source Curated
MedLine Reference 2545359055
Sentence LPS-induced TLR4 Signaling Is Initiated at the Site of the Golgi Apparatus.
Journal J. Exp. Med
Journal Reference v198 i8 p1225 (2003)
Journal Link http://www.jem.org/cgi/content/full/198/8/1225
Source Curated