Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:7189:inout-urn:agi-llid:4615:
Entities MYD88 ---- TRAF6
References 14
MedLine Reference 14661019:1
Sentence Here we show that MAPK-ERK kinase kinase (MEKK3) is an essential signal transducer of the MyD88-IRAK-TRAF6 complex in IL-1R-TLR4 signaling.
Organism Mus musculus
MedLine Reference 16517750:9
Sentence H. pylori infection greatly enhanced MyD88 and TRAF6 complex formation in a cag-dependent manner, but did not enhance Nod1 and receptor-interacting protein 2 complex formation.
Tissue epithelia
Organism Mus musculus
MedLine Reference 15647289:10319
Sentence In response to LPS, MyD88 interacts with TRAF6, which activates downstream signals.
Journal J. Biol. Chem
Journal Reference v280 i12 p11395
Journal Link http://www.jbc.org/cgi/content/full/280/12/11395
Organism Mus musculus
Organism Mus musculus
MedLine Reference 16024789:10200
Journal Mol. Cell. Biol
Journal Reference v25 i15 p6521
Journal Link http://mcb.asm.org/cgi/content/full/25/15/6521
Organism Mus musculus
MedLine Reference 15866876:10201
Journal J. Biol. Chem
Journal Reference v280 i26 p25233
Journal Link http://www.jbc.org/cgi/content/full/280/26/25233
Organism Mus musculus
MedLine Reference 15522835:10062
Journal EBM
Journal Reference v229 i10 p996
Journal Link http://www.ebmonline.org/cgi/content/full/229/10/996
MedLine Reference 12865424:10034
Journal J. Biol. Chem
Journal Reference v278 i39 p37041
Journal Link http://www.jbc.org/cgi/content/full/278/39/37041
Organism Mus musculus
MedLine Reference 15353553:10307
Journal J. Exp. Med
Journal Reference v200 i5 p601
Journal Link http://www.jem.org/cgi/content/full/200/5/601
Organism Mus musculus
MedLine Reference 12297423:1
Sentence Engagement of members of both of these families initiates a common intracellular signaling cascade, in which MyD88 and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) are key adaptor proteins.
Organism drosophila
Source Curated
MedLine Reference 12865424:1035
Sentence MyD88 recruits interleukin-1 receptor-associated kinase (IRAK) and tumor necrosis factor receptor-associated factor-6 (TRAF6), leading to activation of NFkappaB and mitogen-activated protein kinases (MAPKs) ( 24 , 25 ).
Journal J. Biol. Chem
Journal Reference v278 i39 p37041 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/39/37041
Organism mouse
Source Curated
MedLine Reference 12496252:1143
Sentence Upon IL-1 stimulation, adapter molecules MyD88 and Tollip are first recruited to the IL-1 receptor, which in turn recruits IRAK4, IRAK , and TRAF6, resulting in the formation of the receptor complex (Complex 1).
Journal J. Biol. Chem
Journal Reference v278 i13 p10952 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/13/10952
Organism drosophila
Source Curated
CellLineName I1A
MedLine Reference 11751921:1022
Sentence TRAF2 binds TNFR-associated death domain protein, which interacts with TNFR1 ( 10 ), and TRAF6 interacts with interleukin-1 receptor (IL-1R )-associated kinase, which is recruited to the Toll/IL-1R family receptor complexes through MyD88 ( 11 , 12 ).
Source Curated
MedLine Reference 9710600:1108
Source Curated