Binding :


Connectivity	2
Owner	Public
URN	urn:agi-Binding:inout-urn:agi-llid:4615:inout-urn:agi-llid:3654:
Entities	IRAK1 ---- MYD88
References	112


MedLine Reference	11909531:2
Sentence	The interaction of MyD88 with IRAK triggers IRAK phosphorylation, which is essential for its activation and downstream signaling ability.
Organism	Mus musculus


MedLine Reference	14660668:6
Sentence	Kinase activity of IRAK-1 and association between IRAK-1 and MyD88 are also suppressed in PGN-induced tolerant cells.
CellType	macrophage
Organism	Mus musculus
CellLineName	RAW264.7


MedLine Reference	12032143:4
Sentence	After LPS stimulation, an increased IRAK kinase activity, a higher MyD88/IRAK association, and a stronger NF-kappaB activation are observed.
CellType	monocyte


MedLine Reference	12370331:10028
Journal	J. Immunol
Journal Reference	v169 i8 p4075
Journal Link	http://www.jimmunol.org/cgi/content/full/169/8/4075
Organism	Mus musculus


MedLine Reference	12724322:10114
Journal	J. Biol. Chem
Journal Reference	v278 i28 p26258
Journal Link	http://www.jbc.org/cgi/content/full/278/28/26258


MedLine Reference	12893815:10062
Journal	J. Biol. Chem
Journal Reference	v278 i40 p38105
Journal Link	http://www.jbc.org/cgi/content/full/278/40/38105


MedLine Reference	12721283:10190
Journal	J. Biol. Chem
Journal Reference	v278 i27 p24526
Journal Link	http://www.jbc.org/cgi/content/full/278/27/24526
Organism	Mus musculus


MedLine Reference	11976320:10288
Journal	J. Biol. Chem
Journal Reference	v277 i27 p24169
Journal Link	http://www.jbc.org/cgi/content/full/277/27/24169


MedLine Reference	15465816:10026
Journal	J. Biol. Chem
Journal Reference	v279 i49 p51697
Journal Link	http://www.jbc.org/cgi/content/full/279/49/51697
Organism	Mus musculus


MedLine Reference	12351681:10116
Journal	PNAS
Journal Reference	v99 i20 p12871
Journal Link	http://www.pnas.org/cgi/content/full/99/20/12871


MedLine Reference	12034707:10095
Journal	J. Biol. Chem
Journal Reference	v277 i31 p28010
Journal Link	http://www.jbc.org/cgi/content/full/277/31/28010
Organism	Rattus norvegicus


MedLine Reference	15119998:4


MedLine Reference	16461741:8
CellType	monocyte
CellLineName	BLP


MedLine Reference	10811644:2
CellType	promonocyte
CellLineName	THP I


MedLine Reference	16690986:9
Organism	Mus musculus


MedLine Reference	14661019:1
Organism	Mus musculus


MedLine Reference	14625308:10251
Journal	J. Biol. Chem
Journal Reference	v279 i7 p5227
Journal Link	http://www.jbc.org/cgi/content/full/279/7/5227


MedLine Reference	15247281:10130
Journal	J. Biol. Chem
Journal Reference	v279 i36 p37227
Journal Link	http://www.jbc.org/cgi/content/full/279/36/37227


MedLine Reference	15972680:10668
Journal	J. Immunol
Journal Reference	v175 i1 p461
Journal Link	http://www.jimmunol.org/cgi/content/full/175/1/461


MedLine Reference	15294992:10941
Journal	J. Immunol
Journal Reference	v173 i4 p2736
Journal Link	http://www.jimmunol.org/cgi/content/full/173/4/2736


MedLine Reference	12391239:10040
Journal	J. Immunol
Journal Reference	v169 i9 p5209
Journal Link	http://www.jimmunol.org/cgi/content/full/169/9/5209


MedLine Reference	11606776:10112
Journal	PNAS
Journal Reference	v98 i22 p12654
Journal Link	http://www.pnas.org/cgi/content/full/98/22/12654


MedLine Reference	15634926:10631
Journal	J. Immunol
Journal Reference	v174 i2 p1020
Journal Link	http://www.jimmunol.org/cgi/content/full/174/2/1020
Organism	Mus musculus


MedLine Reference	15292196:10309
Journal	J. Biol. Chem
Journal Reference	v279 i39 p40653
Journal Link	http://www.jbc.org/cgi/content/full/279/39/40653
Organism	Mus musculus


MedLine Reference	15767370:10050
Journal	J. Exp. Med
Journal Reference	v201 i6 p915
Journal Link	http://www.jem.org/cgi/content/full/201/6/915
Organism	Mus musculus


MedLine Reference	16024789:10169
Journal	Mol. Cell. Biol
Journal Reference	v25 i15 p6521
Journal Link	http://mcb.asm.org/cgi/content/full/25/15/6521
Organism	Mus musculus


MedLine Reference	12121871:10159
Journal	Gastr. Liver Phys
Journal Reference	v283 i2 pG256
Journal Link	http://ajpgi.physiology.org/cgi/content/full/283/2/G256


MedLine Reference	15282190:10361
Journal	Cell Phys
Journal Reference	v287 i6 p1605
Journal Link	http://ajpcell.physiology.org/cgi/content/full/287/6/C1605
Organism	Mus musculus


MedLine Reference	10373513:10269
Journal	Mol. Cell. Biol
Journal Reference	v19 i7 p4643
Journal Link	http://mcb.asm.org/cgi/content/full/19/7/4643


MedLine Reference	12496438:10326
Journal	J. Immunol
Journal Reference	v170 i1 p508
Journal Link	http://www.jimmunol.org/cgi/content/full/170/1/508
Organism	Mus musculus


MedLine Reference	9575168:10159
Journal	J. Biol. Chem
Journal Reference	v273 i20 p12203
Journal Link	http://www.jbc.org/cgi/content/full/273/20/12203
Organism	Mus musculus


MedLine Reference	12538665:10142
Journal	J. Exp. Med
Journal Reference	v197 i2 p263
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Organism	Mus musculus


MedLine Reference	106100010:11045
Journal	EMBO
Journal Reference	v23 i1 p7600033
Journal Link	http://www.nature.com/emboj/journal/v23/n1/full/7600033a.html


MedLine Reference	11960013:10188
Journal	PNAS
Journal Reference	v99 i8 p5567
Journal Link	http://www.pnas.org/cgi/content/full/99/8/5567


MedLine Reference	15866876:10201
Journal	J. Biol. Chem
Journal Reference	v280 i26 p25233
Journal Link	http://www.jbc.org/cgi/content/full/280/26/25233
Organism	Mus musculus


MedLine Reference	15522835:10062
Journal	EBM
Journal Reference	v229 i10 p996
Journal Link	http://www.ebmonline.org/cgi/content/full/229/10/996


MedLine Reference	16219681:10040
Journal	Cell Sci
Journal Reference	v118 i20 p4589
Journal Link	http://jcs.biologists.org/cgi/content/full/118/20/4589


MedLine Reference	12925671:10184
Journal	J. Exp. Med
Journal Reference	v198 i4 p521
Journal Link	http://www.jem.org/cgi/content/full/198/4/521


MedLine Reference	12517973:10271
Journal	J. Immunol
Journal Reference	v170 i2 p1052
Journal Link	http://www.jimmunol.org/cgi/content/full/170/2/1052
Organism	Mus musculus


MedLine Reference	10224059:10029
Journal	J. Biol. Chem
Journal Reference	v274 i19 p13077
Journal Link	http://www.jbc.org/cgi/content/full/274/19/13077
Organism	Mus musculus


MedLine Reference	11287640:10164
Journal	PNAS
Journal Reference	v98 i8 p4461
Journal Link	http://www.pnas.org/cgi/content/full/98/8/4461


MedLine Reference	11777917:10123
Journal	J. Biol. Chem
Journal Reference	v277 i10 p8048
Journal Link	http://www.jbc.org/cgi/content/full/277/10/8048


MedLine Reference	15917247:10028
Journal	J. Biol. Chem
Journal Reference	v280 i30 p27759
Journal Link	http://www.jbc.org/cgi/content/full/280/30/27759


MedLine Reference	14684752:10023
Journal	J. Biol. Chem
Journal Reference	v279 i6 p4161
Journal Link	http://www.jbc.org/cgi/content/full/279/6/4161
Organism	Rattus norvegicus


MedLine Reference	12865424:10034
Journal	J. Biol. Chem
Journal Reference	v278 i39 p37041
Journal Link	http://www.jbc.org/cgi/content/full/278/39/37041
Organism	Mus musculus


MedLine Reference	12794153:10242
Journal	J. Immunol
Journal Reference	v170 i12 p6217
Journal Link	http://www.jimmunol.org/cgi/content/full/170/12/6217
Organism	Mus musculus


MedLine Reference	10754329:10168
Journal	J. Immunol
Journal Reference	v164 i8 p4301
Journal Link	http://www.jimmunol.org/cgi/content/full/164/8/4301
Organism	Mus musculus


MedLine Reference	14679201:10241
Journal	J. Biol. Chem
Journal Reference	v279 i11 p10776
Journal Link	http://www.jbc.org/cgi/content/full/279/11/10776
Organism	Mus musculus


MedLine Reference	10383454
Sentence	IRAK does not interact with MyD88, whilst the kinase inactive mutant IRAK[Lys239Ser] does interact
Source	Curated


MedLine Reference	11976320:1291
Sentence	Akt and CaMKK decreased the association of IRAK1 with MyD88.
Journal	J. Biol. Chem
Journal Reference	v277 i27 p24169 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/27/24169
Source	Curated


MedLine Reference	12724322:1113
Sentence	We therefore next investigated possible interactions between Btk and MyD88, Mal, and IRAK-1.
CellType	macrophage
Journal	J. Biol. Chem
Journal Reference	v278 i28 p26258 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/28/26258
Source	Curated


MedLine Reference	12032143:1013
Sentence	After LPS stimulation, an increased IRAK kinase activity, a higher MyD88/IRAK association, and a stronger NF-kappaB activation are observed.
CellType	monocyte
Journal	J. Biol. Chem
Journal Reference	v277 i31 p27927 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/31/27927
Organism	drosophila
Source	Curated


MedLine Reference	10497254:1029
Sentence	MyD88, a death domain-containing protein, acts as a proximal adapter in the IL-1R signaling complex by independently interacting with IL-1 receptor accessory protein and IRAK ( 28 ).
Source	Curated


MedLine Reference	10811644:1012
Sentence	LPS also triggers the association of IRAK with MyD88, the adaptor protein linking IRAK to the Toll-like receptor/interleukin-1eta receptor intracellular domain.
CellType	promonocyte
Journal	J. Biol. Chem
Journal Reference	v275 i30 p23340 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/30/23340
Source	Curated
CellLineName	THP I


MedLine Reference	11777917:1123
Sentence	IRAK-1 D/N Inhibits LPS-induced EC Apoptosis-- After Tlr-4 activation and MyD88 recruitment, IRAK-1 transiently binds MyD88 and undergoes an autophosphorylation step leading to its activation ( 12 , 14 , 15 ).
Journal	J. Biol. Chem
Journal Reference	v277 i10 p8048 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/10/8048
Source	Curated


MedLine Reference	12391239:1040
Journal	J. Immunol
Journal Reference	v169 i9 p5209 (2002)
Journal Link	http://www.jimmunol.org/cgi/content/full/169/9/5209
Organism	drosophila
Source	Curated
CellLineName	THP I


MedLine Reference	10754329:1169
CellType	macrophage
Journal	J. Immunol
Journal Reference	v164 i8 p4301 (2000)
Journal Link	http://www.jimmunol.org/cgi/content/full/164/8/4301
Organism	mouse
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


CellType	neutrophil
Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


CellType	neutrophil
Journal	J. Exp. Med
Journal Reference	v198 i4 p521 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/4/521
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


MedLine Reference	12893815:1061
CellType	macrophage
Journal	J. Biol. Chem
Journal Reference	v278 i40 p38105 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/40/38105
Source	Curated


MedLine Reference	11285258:1030
Journal	J. Biol. Chem
Journal Reference	v276 i25 p22041 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/25/22041
Organism	drosophila
Source	Curated


MedLine Reference	10075645:1041
Journal	J. Biol. Chem
Journal Reference	v274 i12 p7611 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/12/7611
Source	Curated


MedLine Reference	9575168:1160
Journal	J. Biol. Chem
Journal Reference	v273 i20 p12203 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/20/12203
Organism	mouse
Source	Curated
CellLineName	293T


MedLine Reference	12865424:1035
Journal	J. Biol. Chem
Journal Reference	v278 i39 p37041 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/39/37041
Organism	mouse
Source	Curated


MedLine Reference	12721283:1191
Journal	J. Biol. Chem
Journal Reference	v278 i27 p24526 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/27/24526
Organism	mouse
Source	Curated


MedLine Reference	12034707:1088
Journal	J. Biol. Chem
Journal Reference	v277 i31 p28010 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/31/28010
Organism	rat
Source	Curated


MedLine Reference	10224059:1028
Journal	J. Biol. Chem
Journal Reference	v274 i19 p13077 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/19/13077
Organism	mouse
Source	Curated


MedLine Reference	12686512:1029
Journal	Cell Phys
Journal Reference	v285 i2 pC399 (2003)
Journal Link	http://ajpcell.physiology.org/cgi/content/full/285/2/C399
Organism	mouse
Source	Curated


MedLine Reference	10783135:1225
CellType	leukocyte
Journal	AJRCMB
Journal Reference	v22 i5 p620 (2000)
Journal Link	http://ajrcmb.atsjournals.org/cgi/content/full/22/5/620
Organism	drosophila
Source	Curated


MedLine Reference	12351681:1117
Journal	PNAS
Journal Reference	v99 i20 p12871 (2002)
Journal Link	http://www.pnas.org/cgi/content/full/99/20/12871
Organism	drosophila
Source	Curated


MedLine Reference	11960013:1188
Journal	PNAS
Journal Reference	v99 i8 p5567 (2002)
Journal Link	http://www.pnas.org/cgi/content/full/99/8/5567
Organism	drosophila
Source	Curated


MedLine Reference	12794153:1243
Journal	J. Immunol
Journal Reference	v170 i12 p6217 (2003)
Journal Link	http://www.jimmunol.org/cgi/content/full/170/12/6217
Organism	mouse
Source	Curated
CellLineName	HENC2


MedLine Reference	12517973:1271
CellType	macrophage
Journal	J. Immunol
Journal Reference	v170 i2 p1052 (2003)
Journal Link	http://www.jimmunol.org/cgi/content/full/170/2/1052
Organism	drosophila
Source	Curated


MedLine Reference	12496438:1326
CellType	macrophage
Journal	J. Immunol
Journal Reference	v170 i1 p508 (2003)
Journal Link	http://www.jimmunol.org/cgi/content/full/170/1/508
Organism	drosophila
Source	Curated


MedLine Reference	12028384:6
Organ	paracrine
Source	Curated


MedLine Reference	11313410:1133
CellType	t cell
Journal	J. Immunol
Journal Reference	v166 i9 p5688 (2001)
Journal Link	http://www.jimmunol.org/cgi/content/full/166/9/5688
Organism	drosophila
Source	Curated


MedLine Reference	11120839:1201
Tissue	peritoneal
CellType	macrophage
Journal	J. Immunol
Journal Reference	v165 i12 p7096 (2000)
Journal Link	http://www.jimmunol.org/cgi/content/full/165/12/7096
Organism	drosophila
Source	Curated


MedLine Reference	10725699:1033
Journal	J. Immunol
Journal Reference	v164 i7 p3476 (2000)
Journal Link	http://www.jimmunol.org/cgi/content/full/164/7/3476
Organism	drosophila
Source	Curated


MedLine Reference	12370331:1028
Tissue	egg
Journal	J. Immunol
Journal Reference	v169 i8 p4075 (2002)
Journal Link	http://www.jimmunol.org/cgi/content/full/169/8/4075
Organism	drosophila
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i3 p513 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/3/513
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i3 p513 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/3/513
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


MedLine Reference	12902324:1319
CellType	b cell
Journal	J. Biol. Chem
Journal Reference	v278 i42 p40590 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/42/40590
Organism	mouse
Source	Curated


MedLine Reference	12695520:1287
CellType	b cell
Journal	J. Biol. Chem
Journal Reference	v278 i25 p22563 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/25/22563
Organism	mouse
Source	Curated


MedLine Reference	12496252:1024
Journal	J. Biol. Chem
Journal Reference	v278 i13 p10952 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/13/10952
Organism	drosophila
Source	Curated


MedLine Reference	11744690:1028
Journal	J. Biol. Chem
Journal Reference	v277 i10 p7808 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/10/7808
Organism	mouse
Source	Curated


MedLine Reference	11751856:1020
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i3 p513 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/3/513
Source	Curated


Journal	J. Exp. Med
Journal Reference	v198 i3 p513 (2003)
Journal Link	http://www.jem.org/cgi/content/full/198/3/513
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


Journal	J. Exp. Med
Journal Reference	v197 i2 p263 (2003)
Journal Link	http://www.jem.org/cgi/content/full/197/2/263
Source	Curated


MedLine Reference	11095740:1031
CellType	macrophage
Journal	PNAS
Journal Reference	v97 i25 p13766 (2000)
Journal Link	http://www.pnas.org/cgi/content/full/97/25/13766
Organism	drosophila
Source	Curated


MedLine Reference	10920188:1037
Journal	PNAS
Journal Reference	v97 i18 p10162 (2000)
Journal Link	http://www.pnas.org/cgi/content/full/97/18/10162
Organism	drosophila
Source	Curated


MedLine Reference	11606776:1112
Journal	PNAS
Journal Reference	v98 i22 p12654 (2001)
Journal Link	http://www.pnas.org/cgi/content/full/98/22/12654
Organism	drosophila
Source	Curated
CellLineName	S2


MedLine Reference	11287640:1166
Journal	PNAS
Journal Reference	v98 i8 p4461 (2001)
Journal Link	http://www.pnas.org/cgi/content/full/98/8/4461
Source	Curated


MedLine Reference	12242293:1080
Journal	Mol. Cell. Biol
Journal Reference	v22 i20 p7158 (2002)
Journal Link	http://mcb.asm.org/cgi/content/full/22/20/7158
Source	Curated


MedLine Reference	11713297:1028
Journal	Mol. Cell. Biol
Journal Reference	v21 i2 p438 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/2/438
Organism	yeast
Source	Curated


MedLine Reference	10373512:1271
Journal	Mol. Cell. Biol
Journal Reference	v19 i7 p4643 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/7/4643
Organism	mouse
Source	Curated
CellLineName	I1A


MedLine Reference	10854325
Source	Curated


MedLine Reference	10588727:1079
Source	Curated


MedLine Reference	9430229:2
Source	Curated