Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:7189:inout-urn:agi-llid:3654:
Entities IRAK1 ---- TRAF6
References 126
MedLine Reference 9514903:3
Sentence In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK.
Organism Mus musculus
MedLine Reference 12566447:8
Sentence Thus, TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation.
Organism Mus musculus
MedLine Reference 12867418:6
Sentence RasN17 overexpression also inhibited CpG ODN-induced IRAK1/TRAF6 complex formation.
CellType macrophage
Organism Mus musculus
CellLineName RAW264.7
MedLine Reference 10346818:10033
Journal Genes & Dev
Journal Reference v13 i10 p1297
Journal Link http://www.genesdev.org/cgi/content/full/13/10/1297
MedLine Reference 15069060:10196
Journal J. Biol. Chem
Journal Reference v279 i24 p25179
Journal Link http://www.jbc.org/cgi/content/full/279/24/25179
MedLine Reference 12034707:10107
Journal J. Biol. Chem
Journal Reference v277 i31 p28010
Journal Link http://www.jbc.org/cgi/content/full/277/31/28010
Organism Rattus norvegicus
MedLine Reference 11823535:10193
Journal J. Immunol
Journal Reference v168 i4 p1984
Journal Link http://www.jimmunol.org/cgi/content/full/168/4/1984
MedLine Reference 11518704:10131
Journal J. Biol. Chem
Journal Reference v276 i45 p41661
Journal Link http://www.jbc.org/cgi/content/full/276/45/41661
MedLine Reference 11287640:10140
Journal PNAS
Journal Reference v98 i8 p4461
Journal Link http://www.pnas.org/cgi/content/full/98/8/4461
MedLine Reference 16751410:6
CellType monocyte
MedLine Reference 14679201:2
Organ immunologic
Organism Mus musculus
MedLine Reference 12138165:2
Organism Mus musculus
MedLine Reference 8837778:5
CellLineName 293
MedLine Reference 12242293:2
MedLine Reference 14661019:1
Organism Mus musculus
MedLine Reference 11259596:6
MedLine Reference 12446795:10034
Journal Mol. Cell. Biol
Journal Reference v22 i24 p8787
Journal Link http://mcb.asm.org/cgi/content/full/22/24/8787
MedLine Reference 9374458:10059
Journal Science
Journal Reference v278 i5343 p1612
Journal Link http://www.sciencemag.org/cgi/content/full/278/5343/1612
MedLine Reference 12496252:10134
Journal J. Biol. Chem
Journal Reference v278 i13 p10952
Journal Link http://www.jbc.org/cgi/content/full/278/13/10952
MedLine Reference 10318845:10293
Journal J. Biol. Chem
Journal Reference v274 i20 p14246
Journal Link http://www.jbc.org/cgi/content/full/274/20/14246
Organism Mus musculus
MedLine Reference 14633973:10038
Journal Genes & Dev
Journal Reference v17 i23 p2933
Journal Link http://www.genesdev.org/cgi/content/full/17/23/2933
Organism Mus musculus
MedLine Reference 12368275:10049
Journal J. Biol. Chem
Journal Reference v277 i51 p49205
Journal Link http://www.jbc.org/cgi/content/full/277/51/49205
Organism Mus musculus
MedLine Reference 16024789:10160
Journal Mol. Cell. Biol
Journal Reference v25 i15 p6521
Journal Link http://mcb.asm.org/cgi/content/full/25/15/6521
Organism Mus musculus
MedLine Reference 11250893:10073
Journal EMBO
Journal Reference v20 i6 p1271
Journal Link http://emboj.oupjournals.org/cgi/content/full/20/6/1271
Organism Mus musculus
MedLine Reference 10075662:10032
Journal J. Biol. Chem
Journal Reference v274 i12 p7724
Journal Link http://www.jbc.org/cgi/content/full/274/12/7724
MedLine Reference 11562344:10460
Journal Genes & Dev
Journal Reference v15 i18 p2321
Journal Link http://www.genesdev.org/cgi/content/full/15/18/2321
MedLine Reference 16221674:10258
Journal J. Biol. Chem
Journal Reference v280 i50 p41289
Journal Link http://www.jbc.org/cgi/content/full/280/50/41289
MedLine Reference 16219681:10041
Journal Cell Sci
Journal Reference v118 i20 p4589
Journal Link http://jcs.biologists.org/cgi/content/full/118/20/4589
MedLine Reference 12631284:10027
Journal Eur. J. Biochem
Journal Reference v270 i6 p1257
Journal Link http://www.ejbiochem.org/cgi/content/full/270/6/1257
MedLine Reference 10811644:10162
Journal J. Biol. Chem
Journal Reference v275 i30 p23340
Journal Link http://www.jbc.org/cgi/content/full/275/30/23340
MedLine Reference 16263713:10164
Journal J. Biol. Chem
Journal Reference v280 i52 p42794
Journal Link http://www.jbc.org/cgi/content/full/280/52/42794
MedLine Reference 10920205:10221
Journal PNAS
Journal Reference v97 i17 p9567
Journal Link http://www.pnas.org/cgi/content/full/97/17/9567
MedLine Reference 10465784:10115
Journal Genes & Dev
Journal Reference v13 i16 p2059
Journal Link http://www.genesdev.org/cgi/content/full/13/16/2059
Organism Mus musculus
MedLine Reference 11724812:10068
Journal J. Cell Biol
Journal Reference v155 i5 p705
Journal Link http://www.jcb.org/cgi/content/full/155/5/705
MedLine Reference 12695520:10155
Journal J. Biol. Chem
Journal Reference v278 i25 p22563
Journal Link http://www.jbc.org/cgi/content/full/278/25/22563
Organism Mus musculus
MedLine Reference 11960013:10029
Journal PNAS
Journal Reference v99 i8 p5567
Journal Link http://www.pnas.org/cgi/content/full/99/8/5567
MedLine Reference 10882729:10040
Journal J. Biol. Chem
Journal Reference v275 i39 p29946
Journal Link http://www.jbc.org/cgi/content/full/275/39/29946
MedLine Reference 16567503:10036
Journal J. Cell Biol
Journal Reference v172 i7 p1057
Journal Link http://www.jcb.org/cgi/content/full/172/7/1057
Organism Mus musculus
MedLine Reference 12902324:10196
Journal J. Biol. Chem
Journal Reference v278 i42 p40590
Journal Link http://www.jbc.org/cgi/content/full/278/42/40590
Organism Mus musculus
MedLine Reference 11418661:10163
Journal J. Immunol
Journal Reference v167 i1 p283
Journal Link http://www.jimmunol.org/cgi/content/full/167/1/283
MedLine Reference 14665666:10039
Journal Genes & Dev
Journal Reference v17 i23 p2855
Journal Link http://www.genesdev.org/cgi/content/full/17/23/2855
MedLine Reference 11744690:10187
Journal J. Biol. Chem
Journal Reference v277 i10 p7808
Journal Link http://www.jbc.org/cgi/content/full/277/10/7808
Organism Mus musculus
MedLine Reference 11447260:10186
Journal PNAS
Journal Reference v98 i15 p8596
Journal Link http://www.pnas.org/cgi/content/full/98/15/8596
Organism Mus musculus
MedLine Reference 12721283:10030
Journal J. Biol. Chem
Journal Reference v278 i27 p24526
Journal Link http://www.jbc.org/cgi/content/full/278/27/24526
Organism Mus musculus
MedLine Reference 12105209:10449
Journal J. Biol. Chem
Journal Reference v277 i38 p34679
Journal Link http://www.jbc.org/cgi/content/full/277/38/34679
MedLine Reference 14585960:10268
Journal Mol. Cell. Biol
Journal Reference v23 i22 p7982
Journal Link http://mcb.asm.org/cgi/content/full/23/22/7982
MedLine Reference 12874243:10241
Journal J. Immunol
Journal Reference v171 i3 p1500
Journal Link http://www.jimmunol.org/cgi/content/full/171/3/1500
MedLine Reference 9371760:10018
Journal PNAS
Journal Reference v94 i24 p12829
Journal Link http://www.pnas.org/cgi/content/full/94/24/12829
Organism Mus musculus
MedLine Reference 131100255:11117
MedLine Reference 15866876:10201
Journal J. Biol. Chem
Journal Reference v280 i26 p25233
Journal Link http://www.jbc.org/cgi/content/full/280/26/25233
Organism Mus musculus
MedLine Reference 10747026:10114
Journal EMBO
Journal Reference v19 i7 p1576
Journal Link http://emboj.oupjournals.org/cgi/content/full/19/7/1576
MedLine Reference 11865024:10147
Journal Cell Sci
Journal Reference v115 i4 p679
Journal Link http://jcs.biologists.org/cgi/content/full/115/4/679
MedLine Reference 15522835:10062
Journal EBM
Journal Reference v229 i10 p996
Journal Link http://www.ebmonline.org/cgi/content/full/229/10/996
MedLine Reference 10903731:10034
Journal J. Immunol
Journal Reference v165 i3 p1307
Journal Link http://www.jimmunol.org/cgi/content/full/165/3/1307
MedLine Reference 15240720:10592
Journal J. Immunol
Journal Reference v173 i2 p1276
Journal Link http://www.jimmunol.org/cgi/content/full/173/2/1276
Organism Mus musculus
MedLine Reference 15701712:10293
Journal Blood
Journal Reference v105 i12 p4685
Journal Link http://www.bloodjournal.org/cgi/content/full/105/12/4685
Organism Mus musculus
MedLine Reference 14625308:10261
Journal J. Biol. Chem
Journal Reference v279 i7 p5227
Journal Link http://www.jbc.org/cgi/content/full/279/7/5227
MedLine Reference 14739303:10023
Journal J. Biol. Chem
Journal Reference v279 i15 p15652
Journal Link http://www.jbc.org/cgi/content/full/279/15/15652
Organism Mus musculus
MedLine Reference 15728517:10543
Journal J. Immunol
Journal Reference v174 i5 p3032
Journal Link http://www.jimmunol.org/cgi/content/full/174/5/3032
MedLine Reference 10383454:10024
Journal J. Biol. Chem
Journal Reference v274 i27 p19403
Journal Link http://www.jbc.org/cgi/content/full/274/27/19403
MedLine Reference 15793310:10032
Journal J. Biol. Chem
Journal Reference v280 i23 p21997
Journal Link http://www.jbc.org/cgi/content/full/280/23/21997
Organism Rattus norvegicus
MedLine Reference 15849359:10050
Journal J. Biol. Chem
Journal Reference v280 i24 p23173
Journal Link http://www.jbc.org/cgi/content/full/280/24/23173
Organism Mus musculus
MedLine Reference 15271679:10174
Journal Reg.Int.Comp.Phys
Journal Reference v287 i2 p298
Journal Link http://ajpregu.physiology.org/cgi/content/full/287/2/R298
Organism Mus musculus
MedLine Reference 16477006:10045
Journal PNAS
Journal Reference v103 i8 p2689
Journal Link http://www.pnas.org/cgi/content/full/103/8/2689
MedLine Reference 101000787:11199
Journal Cell
Journal Reference v90 i2 p373
Journal Link http://www.cell.com/cgi/content/full/90/2/373
MedLine Reference 101002650:11033
Journal Cell
Journal Reference v103 i7 p993
Journal Link http://www.cell.com/cgi/content/full/103/7/993
MedLine Reference 15894263
Sentence TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species
Source Curated
MedLine Reference 11865024:1147
Sentence Even though biochemical characterizations suggest that TRAF6-receptor and TRAF6-IRAK interactions differ from receptor recognition by other TRAFs (Pullen et al., 1998 ; Darnay et al., 1999 ), elucidation of the molecular mechanism of TRAF6 upstream interactions awaits further structural information.
Journal Cell Sci
Journal Reference v115 i4 p679 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/4/679
Source Curated
MedLine Reference 12138165:1011
Journal J. Biol. Chem
Journal Reference v277 i40 p37414 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/40/37414
Organism mouse
Source Curated
MedLine Reference 12034707:1101
Journal J. Biol. Chem
Journal Reference v277 i31 p28010 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/31/28010
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 11744690:1189
Journal J. Biol. Chem
Journal Reference v277 i10 p7808 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/10/7808
Organism mouse
Source Curated
MedLine Reference 11518704:1119
Journal J. Biol. Chem
Journal Reference v276 i45 p41661 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/45/41661
Source Curated
MedLine Reference 10882729:1040
Journal J. Biol. Chem
Journal Reference v275 i39 p29946 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/39/29946
Source Curated
MedLine Reference 10811644:1152
Journal J. Biol. Chem
Journal Reference v275 i30 p23340 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/30/23340
Source Curated
CellLineName THP I
MedLine Reference 10383454:1025
Journal J. Biol. Chem
Journal Reference v274 i27 p19403 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/27/19403
Organism drosophila
Source Curated
MedLine Reference 10362687:1115
Journal Heart Circul
Journal Reference v276 i6 pH2053 (1999)
Journal Link http://ajpheart.physiology.org/cgi/content/full/276/6/H2053
Organism pig
Source Curated
CellLineName 293
MedLine Reference 11562344:1460
CellType macrophage
Journal Genes & Dev
Journal Reference v15 i18 p2321 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/18/2321
Source Curated
MedLine Reference 10465784:1115
Journal Genes & Dev
Journal Reference v13 i16 p2059 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/16/2059
Organism drosophila
Source Curated
CellLineName 293
MedLine Reference 12631284:1025
Journal Eur. J. Biochem
Journal Reference v270 i6 p1257 (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/270/6/1257
Source Curated
MedLine Reference 10747026:1115
Journal EMBO
Journal Reference v19 i7 p1576 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/7/1576
Source Curated
CellLineName HepG 2
Organ immunologic
Journal Cell
Journal Reference v103 i7 p993 (2000)
Journal Link http://www.cell.com/cgi/content/full/103/7/993
Source Curated
Organ immunologic
Journal Cell
Journal Reference v103 i7 p993 (2000)
Journal Link http://www.cell.com/cgi/content/full/103/7/993
Source Curated
MedLine Reference 10903731:1034
Journal J. Immunol
Journal Reference v165 i3 p1307 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/3/1307
Source Curated
Journal J. Exp. Med
Journal Reference v197 i4 p537 (2003)
Journal Link http://www.jem.org/cgi/content/full/197/4/537
Source Curated
Journal J. Exp. Med
Journal Reference v197 i4 p537 (2003)
Journal Link http://www.jem.org/cgi/content/full/197/4/537
Source Curated
MedLine Reference 10190904:1269
CellType fibroblast
Journal J. Exp. Med
Journal Reference v189 i7 p1129 (1999)
Journal Link http://www.jem.org/cgi/content/full/189/7/1129
Organism mouse
Source Curated
MedLine Reference 11724812:1068
Journal J. Cell Biol
Journal Reference v155 i5 p705 (2001)
Journal Link http://www.jcb.org/cgi/content/full/155/5/705
Organism drosophila
Source Curated
MedLine Reference 13679373:1033
Journal J. Biol. Chem
Journal Reference v278 i49 p49145 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/49/49145
Organism mouse
Source Curated
MedLine Reference 11976320:1027
Journal J. Biol. Chem
Journal Reference v277 i27 p24169 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/27/24169
Source Curated
MedLine Reference 11880380:1029
Journal J. Biol. Chem
Journal Reference v277 i19 p16456 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/19/16456
Organism mouse
Source Curated
MedLine Reference 11836257:1029
Journal J. Biol. Chem
Journal Reference v277 i17 p15028 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/17/15028
Organism drosophila
Source Curated
MedLine Reference 12902324:1196
Journal J. Biol. Chem
Journal Reference v278 i42 p40590 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/42/40590
Organism mouse
Source Curated
MedLine Reference 12867418:1017
CellType macrophage
Journal J. Biol. Chem
Journal Reference v278 i38 p36334 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/38/36334
Organism mouse
Source Curated
CellLineName RAW264.7
MedLine Reference 12721283:1030
Journal J. Biol. Chem
Journal Reference v278 i27 p24526 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/27/24526
Organism mouse
Source Curated
MedLine Reference 12695520:1155
Journal J. Biol. Chem
Journal Reference v278 i25 p22563 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/25/22563
Organism mouse
Source Curated
MedLine Reference 12566447:1013
Journal J. Biol. Chem
Journal Reference v278 i14 p12144 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/14/12144
Organism mouse
Source Curated
MedLine Reference 12496252:1129
Journal J. Biol. Chem
Journal Reference v278 i13 p10952 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/13/10952
Organism drosophila
Source Curated
MedLine Reference 12368275:1049
Journal J. Biol. Chem
Journal Reference v277 i51 p49205 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49205
Organism mouse
Source Curated
MedLine Reference 11287640:1137
Journal PNAS
Journal Reference v98 i8 p4461 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/8/4461
Source Curated
CellLineName 293
MedLine Reference 10920205:1037
Tissue bone
CellType osteoclast
Journal PNAS
Journal Reference v97 i17 p9567 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/17/9567
Source Curated
MedLine Reference 11809792:1033
Tissue bone
CellType osteoclast
Journal Mol. Cell. Biol
Journal Reference v22 i4 p992 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/4/992
Organism mouse
Source Curated
MedLine Reference 11713297:1029
Journal Mol. Cell. Biol
Journal Reference v21 i2 p438 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/2/438
Organism yeast
Source Curated
MedLine Reference 11416132:1031
Journal Mol. Cell. Biol
Journal Reference v21 i14 p4544 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/14/4544
Organism drosophila
Source Curated
MedLine Reference 10373512:1025
Journal Mol. Cell. Biol
Journal Reference v19 i7 p4643 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/7/4643
Organism mouse
Source Curated
MedLine Reference 14585960:1267
Organ eye
Journal Mol. Cell. Biol
Journal Reference v23 i22 p7982 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/22/7982
Organism drosophila
Source Curated
MedLine Reference 12446795:1034
Journal Mol. Cell. Biol
Journal Reference v22 i24 p8787 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/24/8787
Organism drosophila
Source Curated
MedLine Reference 10341247:1012
Tissue microglia
Journal J. Neurosci
Journal Reference v19 i11 p4462 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/11/4462
Organism mouse
Source Curated
MedLine Reference 10217305:1123
Tissue microglia
Journal J. Neurochem
Journal Reference v72 i5 p2215 (1999)
Journal Link http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc
Organism mouse
Source Curated
MedLine Reference 11971008:1011
CellType macrophage
Journal J. Immunol
Journal Reference v168 i9 p4601 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/168/9/4601
Organism mouse
Source Curated
MedLine Reference 11823535:1193
Journal J. Immunol
Journal Reference v168 i4 p1984 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/168/4/1984
Source Curated
CellLineName THP I
MedLine Reference 10754329:1176
Journal J. Immunol
Journal Reference v164 i8 p4301 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/8/4301
Organism mouse
Source Curated
MedLine Reference 10201956:1188
CellType hepatocyte
Journal J. Immunol
Journal Reference v162 i7 p4260 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/7/4260
Organism mouse
Source Curated
MedLine Reference 8837778
Source Curated
MedLine Reference 9625770:1018
Source Curated
MedLine Reference 12105209:1452
Source Curated
MedLine Reference 10318845:1283
Source Curated
MedLine Reference 10346818:1031
Journal Cell
Journal Reference v90 i2 p373 (1997)
Journal Link http://www.cell.com/cgi/content/full/90/2/373
Source Curated
MedLine Reference 10215628:1035
Journal Cell
Journal Reference v90 i2 p373 (1997)
Journal Link http://www.cell.com/cgi/content/full/90/2/373
Source Curated
Journal Science
Journal Reference v278 i5343 p1612 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/278/5343/1612
Source Curated
Journal Science
Journal Reference v278 i5343 p1612 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/278/5343/1612
Source Curated
MedLine Reference 9374458:1059
Journal Science
Journal Reference v278 i5343 p1612 (1997)
Journal Link http://www.sciencemag.org/cgi/content/full/278/5343/1612
Organism drosophila
Source Curated
MedLine Reference 9520446:1024
Journal PNAS
Journal Reference v95 i7 p3792 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/7/3792
Source Curated
MedLine Reference 9371760:1018
Journal PNAS
Journal Reference v94 i24 p12829 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/24/12829
Organism mouse
Source Curated
MedLine Reference 11960013:1029
Journal PNAS
Journal Reference v99 i8 p5567 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/8/5567
Organism drosophila
Source Curated
MedLine Reference 11447260:1187
Journal PNAS
Journal Reference v98 i15 p8596 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/15/8596
Organism drosophila
Source Curated
MedLine Reference 3523157157
Sentence IL-1 stimulation induces the formation of a complex between IRAK and TRAF6 that is dissociated from the IL-1 receptor complex ( Cao et al., 1996a ).
Journal Cell
Journal Reference v90 i2 p373 (1997)
Journal Link http://www.cell.com/cgi/content/full/90/2/373
Source Curated