Protein : Braf
Owner Public
URN urn:agi-llid:673
Hugo ID 1097
Connectivity 387
Name Braf
Description v-raf murine sarcoma viral oncogene homolog B1
Notes human homolog is a serine/threonine kinase; mutation of gene is associated with human cancers [RGD]
RGD ID 619908
Pathway p40 MAPK
MAPK-ERK in Growth and Differentiation
G-protein Coupled Receptor signaling
AGTR1 -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
AGTR1 -> TP53 signaling pathway
AGTR2 -> CREB1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
VIPR1 -> CEBPD signaling pathway
AGTR2 -> TP53 signaling pathway
VIPR1 -> CREB1 signaling pathway
B-cell receptor -> AP-1 signaling pathway
ENDRB -> AP-1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
CCKAR -> ELK1-SRF signaling pathway
CCKAR -> ELK4-SRF signaling pathway
PTGIR -> ATF1 signaling pathway
CCKBR -> ELK1-SRF signaling pathway
CCKBR -> ELK4-SRF signaling pathway
PTGIR -> CREB1 signaling pathway
PTGIR -> ELK1-SRF signaling pathway
PTGIR -> ELK4-SRF signaling pathway
PTGIR -> MYC signaling pathway
TACR1 -> ELK1-SRF signaling pathway
CD22/72 -> AP-1 signaling pathway
TACR1 -> ELK4-SRF signaling pathway
TBXA2R -> CREB1 signaling pathway
FSHR -> CREB1 signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> AP-1 signaling pathway
FSHR -> GATA4 signaling pathway
GCGR -> CREB1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
GCGR -> ELK1-SRF signaling pathway
GCGR -> ELK4-SRF signaling pathway
ITGB1 -> SREBF2 signaling pathway
GCGR -> SP1 signaling pathway
CHRM1 -> CREB1 signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
CNRs -> CREB1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
ADRB1 -> STAT3 signaling pathway
GRIN1 -> CREB1 signaling pathway
ADRB2 -> CREB1 signaling pathway
GRM1/5 -> CREB1 signaling pathway
ADRB2 -> STAT3 signaling pathway
ADRB3 -> STAT3 signaling pathway
DRD1 -> CREB1 signaling pathway
ICAM1 -> CREB1 signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
ICAM1 -> MYC signaling pathway
AGTR1 -> CREB1 signaling pathway
Group Kinases
cellular physiological process
intracellular signaling cascade
anti-apoptosis
protein amino acid phosphorylation
regulation of transcription, DNA-dependent
organ morphogenesis
intracellular
cytoplasm
nucleus
plasma membrane
nucleotide binding
protein binding
metal ion binding
zinc ion binding
diacylglycerol binding
DNA binding
ATP binding
mitogen-activated protein kinase kinase binding
protein heterodimerization activity
transferase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase kinase kinase activity
receptor signaling protein activity
GenBank ID NC_000007
NM_004333
NP_004324
NT_007914
NT_079596
NW_923640
AC_000050
AC_000068
AC006006
AAS00359
AC006344
AAD43193
AC006347
AAD15551
AC079339
CH236950
EAL24023
X65187
CAA46301
AA834931
AI203435
AK054801
BC038966
BC101757
AAI01758
BC112079
AAI12080
BM263585
DN996440
M21001
AAA96495
M95712
AAA35609
P15056
Q75MQ8
Q9UDP8
NC_005103
XM_231692
XP_231692
NW_001084827
XM_001070228
XP_001070228
NW_047690
AC_000072
AF352172
AAK32708
Source Curated
LocusLink ID 673
114486
Organism Homo sapiens
Rattus norvegicus
OMIM ID 164757
211980
115150
Alias BRAF1
RAFB1
B-raf 1
MGC126806
MGC138284
v-raf murine sarcoma viral oncogene homolog B1
94 kDa B-raf protein
Murine sarcoma viral (v-raf) oncogene homolog B1
GO ID 0005524
0019992
0046872
0000166
0004674
0005057
0016740
0008270
0006916
0007242
0009887
0006468
0003677
0004709
0031434
0005515
0046982
0004713
0050875
0006355
0005737
0005622
0005634
0005886
Swiss-Prot Accession P15056
Q75MQ8
Q9UDP8
Unigene ID Hs.550061
Rn.99177