Protein : PTK2B


Owner	Public
URN	urn:agi-llid:2185
Hugo ID	9612
Connectivity	746
Name	PTK2B
Description	protein tyrosine kinase 2 beta
Notes	may phosphorylate focal adhesion kinase FAK; may play a role in actin cytoskeleton reorganization; may mediate thrombin induced astrocyte proliferation [RGD]


RGD ID	628758


MGI ID	104908


Pathway	Neurotensin
	Neuropeptide Y
	ACH-R in apoptosis
	opioids OPRD1
	MAPK-ERK in Growth and Differentiation
	G-protein Coupled Receptor signaling
	Bombesin
	Oxytocin
	Vasopressin
	Cholecystokinin
	Gastrin
	Substance P
	Endothelin
	Nociceptin
	EGFR -> AP-1 signaling pathway
	NTRK1 -> SMAD3 signaling pathway
	NTRKs -> AP-1 signaling pathway
	NTRKs -> CREB1 signaling pathway
	NTRKs -> ELK1-SRF signaling pathway
	NTRKs -> ELK4-SRF signaling pathway
	EGFR -> ATF2 signaling pathway
	NTRKs -> MYC signaling pathway
	NTRKs -> STAT5A signaling pathway
	NTRKs -> TP53 signaling pathway
	ERBB2/3 -> SP1 signaling pathway
	OPRs -> STAT3 signaling pathway
	EGFR/ERBB2 -> TP53 signaling pathway
	EGFR/ERBB3 -> MEF2A signaling pathway
	EGFR/ERBB3 -> MEF2C signaling pathway
	CCKBR -> STAT1 signaling pathway
	CCKBR -> STAT3 signaling pathway
	ERBB2 -> ETS2 signaling pathway
	ERBB2 -> ETV1 signaling pathway
	CD28 -> ATF1 signaling pathway
	CD28 -> ATF2 signaling pathway
	CD28 -> CREB1 signaling pathway
	ITGAM/ITGB2 -> CEBPB signaling pathway
	ITGAM/ITGB2 -> NF-kB signaling pathway
	ADORA1 -> NF-kB signaling pathway
	GFRs -> AP-1 signaling pathway
	GFRs -> CREB1 signaling pathway
	GFRs -> CREBBP signaling pathway
	GFRs -> ELK1-SRF signaling pathway
	GFRs -> ELK4-SRF signaling pathway
	CHRM1 -> CREB1 signaling pathway
	GFRs -> MYC signaling pathway
	GFRs -> NCOR2 signaling pathway
	KIT -> MITF signaling pathway
	CHRM1 -> ELK1-SRF signaling pathway
	CHRM1 -> ELK4-SRF signaling pathway
	ACH-R in apoptosis'-2


Group	Kinases
	cell adhesion
	signal transduction
	signal complex formation
	apoptosis
	positive regulation of cell proliferation
	protein amino acid phosphorylation
	protein complex assembly
	response to stress
	cytoplasm
	cytoskeleton
	signal transducer activity
	nucleotide binding
	protein binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	non-membrane spanning protein tyrosine kinase activity


Source	Curated


OMIM ID	601212


Alias	PKB
	PTK
	CAKB
	FAK2
	PYK2
	CADTK
	FADK2
	RAFTK
	PTK2B protein tyrosine kinase 2 beta
	CAK beta
	protein kinase B
	focal adhesion kinase 2
	cell adhesion kinase beta
	proline-rich tyrosine kinase 2
	protein tyrosine kinase 2 beta
	calcium-dependent tyrosine kinase
	related adhesion focal tyrosine kinase
	A6
	CAK[B]
	CAKbeta
	E430023O05Rik
	PTK2 protein tyrosine kinase 2 beta
	cellular adhesion kinase beta
	MGC124628