Protein : SRF
Owner Public
URN urn:agi-llid:6722
Hugo ID 11291
Connectivity 554
Name SRF
Description similar to serum response factor (predicted)
Notes This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
RGD ID 1559787
MGI ID 106658
Cell Localization Nucleus
Pathway p38 MAPK
p40 MAPK
Insulin pathway
EGF signaling
PDGF signaling
MAPK-ERK in Growth and Differentiation
IL-6 signaling
AGTR1 -> ELK1-SRF signaling pathway
Notch -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
Notch -> ELK4-SRF signaling pathway
EDG2 -> ELK4-SRF signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
IGF1R -> ELK1-SRF signaling pathway
IGF1R -> ELK4-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
OPRs -> ELK4-SRF signaling pathway
PLAUR -> ELK1-SRF signaling pathway
PLAUR -> ELK4-SRF signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
PTGFR -> ELK4-SRF signaling pathway
CCKAR -> ELK1-SRF signaling pathway
SELE -> ELK4-SRF signaling pathway
CCKAR -> ELK4-SRF signaling pathway
CCKBR -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
CCKBR -> ELK4-SRF signaling pathway
PTGIR -> ELK1-SRF signaling pathway
PTGIR -> ELK4-SRF signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
CD19 -> ELK1-SRF signaling pathway
CD19 -> ELK4-SRF signaling pathway
TACR1 -> ELK1-SRF signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
TACR1 -> ELK4-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
TGFBR -> ELK1-SRF signaling pathway
TGFBR -> ELK4-SRF signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
CD38 -> ELK1-SRF signaling pathway
CD38 -> ELK4-SRF signaling pathway
GCGR -> ELK1-SRF signaling pathway
GCGR -> ELK4-SRF signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
LEPR -> ELK1-SRF signaling pathway
LEPR -> ELK4-SRF signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
HTR2A -> ELK1-SRF signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
HTR2A -> ELK4-SRF signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
DRD2 -> ELK1-SRF signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Group Transcription factors
development
signal transduction
transport
transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
heart development
heart looping
muscle maintenance
membrane
nucleus
transporter activity
protein binding
DNA binding
sequence-specific DNA binding
transcription factor activity
transcription factor binding
RNA polymerase II transcription factor activity
GenBank ID NC_000006
NM_003131
NP_003122
NT_007592
NW_923073
AC_000049
AL133375
CAI20207
AL355385
CAI13785
AI085561
BC048211
AAH48211
BC052572
AAH52572
CR594188
CR595609
J03161
AAA36647
P11831
Q5T648
NC_000083
NM_020493
NP_065239
NT_039649
NW_000130
NW_001030618
AC_000039
AB038376
BAA92314
AC165445
U49759
BC051950
AAH51950
BI662291
Q9JM73
NC_005108
XM_576514
XP_576514
NW_001084880
XM_001063545
XP_001063545
NW_047813
AC_000077
Source Curated
LocusLink ID 6722
20807
501099
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600589
Alias serum response factor (c-fos serum response element-binding transcription factor)
OTTHUMP00000039820
AW049942
AW240594
serum response factor
similar to serum response factor (predicted)
GO ID 0003702
0043565
0003700
0008134
0007275
0006357
0007165
0006350
0005634
0003677
0005515
0005215
0007507
0001947
0046716
0045944
0006355
0006810
0016020
Swiss-Prot Accession P11831
Q5T648
Q9JM73
Unigene ID Hs.520140
Mm.45044