ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-protfc:growth%20factor%20receptor:out-urn:agi-llid:6464::unknown
Entities growth factor receptor ---> SHC1
References 3
Connectivity 2
Effect unknown
MedLine Reference 9950219:1024
Sentence Activated ErbB2 and other growth factor receptors phosphorylate Shc on tyrosine 317, which in turn is recognized by the SH2 domain of Grb2, typically found complexed with SOS (reviewed in Refs. 19 and 20 ).
Journal Cell Growth and Diff
Journal Reference v10 i1 p61.htm (1999)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/10/1/61.ht
Source Curated
MedLine Reference 8995240:1206
Sentence Shc Phosphorylation and MAP Kinase Activity Growth factor receptors activate the Ras/MAP kinase pathway by phosphorylating Shc and recruiting Grb2-Sos complexes to membranes via the SH2 domain of Grb2 ( 39 , 40 , 41 ).
Journal J. Biol. Chem
Journal Reference v272 i1 p146 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/1/146
Source Curated
MedLine Reference 7534289:1117
Sentence Like other tyrosine kinase growth factor receptors, the IGF-I and insulin receptors are known to phosphorylate Shc proteins( 17 , 18 , 19 , 20 , 21 ) , which can then associate with the Grb2-mSos complex, leading to activation of Ras and the subsequent Raf and mitogen-activated protein kinase pathways( 26 , 27 , 28 ) .
Journal J. Biol. Chem
Journal Reference v270 i10 p5187 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/10/5187
CellLineName 293
Organism mouse
Source Curated