Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:2889:out-urn:agi-llid:5906::positive
Entities GRF2 --+> RAP1A
References 4
Connectivity 2
MedLine Reference 8943292:10307
Sentence C3G is a nucleotide exchange factor that activates the Rap1A and Rap1B G proteins ( 17 ).
Journal J. Biol. Chem
Journal Reference v271 i50 p32306
Journal Link http://www.jbc.org/cgi/content/full/271/50/32306
MedLine Reference 9497377:10169
Sentence One of the major Crk SH3 domain-binding proteins, C3G, is a guanine nucleotide exchange factor that activates a small GTPase, Rap1A/K-rev1 ( 15 ).
Journal J. Biol. Chem
Journal Reference v273 i11 p6446
Journal Link http://www.jbc.org/cgi/content/full/273/11/6446
MedLine Reference 10464310:10329
Sentence Whereas Sos regulates Ras activity, C3G has been reported to activate Rap1/smgp21/Krev-1 ( 48 ), a Ras-related GTPase, which counteracts the effects of Ras in transformation ( 49 ).
Journal J. Biol. Chem
Journal Reference v274 i36 p25726
Journal Link http://www.jbc.org/cgi/content/full/274/36/25726
MedLine Reference 8943292:1309
Sentence C3G is a nucleotide exchange factor that activates the Rap1A and Rap1B G proteins ( 17 ).
Source Curated