Regulation :

Effect positive
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:7440-70-2:out-urn:agi-llid:5595::positive:phosphorylation
Entities Ca2+ --+> MAPK3
References 58
Connectivity 2
MedLine Reference 16569214:3
Sentence Herein we describe a mechanism by which NO* blocks Ca2+-mediated ERK1/2 activity through direct modification of H-Ras.
MedLine Reference 14743432:1
Sentence Here we show that elevated Ca2+(o) stimulates extracellular-signal-regulated kinase (ERK1/2) and p38 MAP kinase (MAPK).
MedLine Reference 12420221:2
Sentence Markers of tumor invasion, cathepsin L and TGFbeta1, were overexpressed; calcium-dependent MAP kinases (ERK1 and ERK2) and calcineurin were activated.
MedLine Reference 14670995:10195
Journal Endocrinology
Journal Reference v145 i4 p1718
Journal Link http://endo.endojournals.org/cgi/content/full/145/4/1718
Organism Mus musculus
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Journal Heart Circul
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Journal Endocrin. Metabol
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Journal Link http://ajpendo.physiology.org/cgi/content/full/285/2/E329
Organism Rattus norvegicus
MedLine Reference 9235901:10248
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/272/31/19125
Organism Rattus norvegicus
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Organism Mus musculus
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Journal Circulation Res
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Organism Mus musculus
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Journal Cell Phys
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Organism Mus musculus
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Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/277/17/15190
MedLine Reference 15853814:8
Organism Mus musculus
CellLineName HEK 293
MedLine Reference 10935495:4
Organism Mus musculus
CellLineName NIH 3T3
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Journal Mol. Cell. Biol
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Journal Link http://mcb.asm.org/cgi/content/full/23/12/4066
Organism Mus musculus
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Journal Link http://ajpcell.physiology.org/cgi/content/full/283/5/C1351
Organism Rattus norvegicus
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Journal ATVB
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Journal Link http://atvb.ahajournals.org/cgi/content/full/24/6/1074
Organism Mus musculus
MedLine Reference 16418226:10460
Journal Cell Sci
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Organism Mus musculus
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Journal Cell Phys
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Organism Mus musculus
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Journal J. Immunol
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Journal Link http://www.jimmunol.org/cgi/content/full/172/9/5588
Organism Mus musculus
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Journal J. Biol. Chem
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Organism Mus musculus
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Journal Cell Phys
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Journal Link http://ajpcell.physiology.org/cgi/content/full/286/6/C1281
Organism Mus musculus
MedLine Reference 12529254:10190
Journal Cell Phys
Journal Reference v284 i2 pC571
Journal Link http://ajpcell.physiology.org/cgi/content/full/284/2/C571
Organism Rattus norvegicus
MedLine Reference 16567530:10221
Journal Diabetes
Journal Reference v55 i4 p1066
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/55/4/1066
Organism Rattus norvegicus
MedLine Reference 12865341:10379
Journal Endocrinology
Journal Reference v144 i8 p3586
Journal Link http://endo.endojournals.org/cgi/content/full/144/8/3586
Organism Mus musculus
MedLine Reference 15955068:10158
Journal Eur. J. Biochem
Journal Reference v272 i12 p3093
Journal Link http://content.febsjournal.org/cgi/content/full/272/12/3093
MedLine Reference 11406465:10170
Journal Heart Circul
Journal Reference v281 i1 pH30
Journal Link http://ajpheart.physiology.org/cgi/content/full/281/1/H30
Organism Mus musculus
MedLine Reference 131103802:11011
MedLine Reference 131103111:11181
MedLine Reference 131101789:11079
MedLine Reference 131101840:11117
MedLine Reference 131101776:11131
MedLine Reference 110003480:11012
Journal J. Cell Biol
Journal Reference v166 i5 p607
Journal Link http://www.jcb.org/cgi/content/full/166/5/607
MedLine Reference 9698606:1020
Sentence The activation of ERK1 and ERK2 appears to be primarily dependent on PKC, and to be partly modulated by Ca2+/calmodulin and by activation of tyrosine kinases.
Journal AJRCMB
Journal Reference v19 i2 p324 (1998)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/19/2/324
Organism rat
Source Curated
MedLine Reference 11880263:1031
Sentence The results indicate that Ca 2+ -dependent activation of ERK1/2 in VSM cells is completely dependent on PYK2/ src activation and transactivation of EGF receptor.
Journal Cell Phys
Journal Reference v282 i4 pC754 (2002)
Journal Link http://ajpcell.physiology.org/cgi/content/full/282/4/C754
Organism rat
Source Curated
CellLineName VSM
MedLine Reference 12529254:1189
Sentence The present study provides direct evidence that the P2X7-R can mediate ERK1/2 activation through a cellular pathway that is dependent on intracellular and extracellular Ca2+, Pyk2, c-Src, PI 3-K, and MEK1/2.
Journal Cell Phys
Journal Reference v284 i2 pC571 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/284/2/C571
Organism rat
Source Curated
CellType macrophage
MedLine Reference 10559418:1250
Sentence Chelating intracellular Ca 2+ with BAPTA-AM inhibits both glutamate-dependent RAFTK phosphorylation and ERK1/2 activation, whereas pretreatment of primary astrocytes with calcium ionophore results in RAFTK phosphorylation and ERK1/2 activation in the absence of glutamate.
Journal J. Neurosci
Journal Reference v19 i22 p10107 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/22/10107
Organism mouse
Source Curated
CellType astrocyte
MedLine Reference 9885231:1013
Sentence Incubation with glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]]-bis[(acetyloxy)methyl]ester (BAPTA,AM), an intracellular chelator of calcium, failed to block either phagocytosis or ERK1 and ERK2 phosphorylation, consistent with the absence of a role for a calcium-dependent protein kinase C (PKC) in ERK1 and ERK2 phosphorylations.
Journal Blood
Journal Reference v93 i2 p686 (1999)
Journal Link http://www.bloodjournal.org/cgi/content/full/93/2/686
Source Curated
CellType leukocyte
MedLine Reference 14583469:2
Organism rat
Source Curated
CellLineName h508
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Organism rat
Source Curated
MedLine Reference 11069934:1143
Journal J. Neurosci
Journal Reference v20 i22 p8279 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/22/8279
Organism rat
Source Curated
CellType astrocyte
MedLine Reference 10066263:1144
Journal J. Neurosci
Journal Reference v19 i6 p2102 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/6/2102
Organ hippocampal
Source Curated
CellLineName SH-SY5Y
MedLine Reference 10024343:1101
Journal J. Neurosci
Journal Reference v19 i5 p1557 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/5/1557
Organism drosophila
Source Curated
MedLine Reference 9235901:1240
Journal J. Biol. Chem
Journal Reference v272 i31 p19125 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/31/19125
Organism rat
Source Curated
CellType neutrophil
CellLineName COS-7
MedLine Reference 12446705:1305
Journal J. Biol. Chem
Journal Reference v278 i5 p2866 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/5/2866
Source Curated
CellLineName GT1-7
MedLine Reference 11836255:1212
Journal J. Biol. Chem
Journal Reference v277 i17 p15190 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/17/15190
Source Curated
CellLineName HF
MedLine Reference 12192097:1204
Journal EBM
Journal Reference v227 i8 p561 (2002)
Journal Link http://www.ebmonline.org/cgi/content/full/227/8/561
Organ heart
Organism bovine
Source Curated
CellType myocyte
MedLine Reference 9751775:2
Organism rat
Source Curated
MedLine Reference 12773552:1359
Journal Mol. Cell. Biol
Journal Reference v23 i12 p4066 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/12/4066
Organism mouse
Source Curated
CellLineName UMR 106
MedLine Reference 11731477:1026
Tissue vascular
Journal Genes & Dev
Journal Reference v15 i23 p3130 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/23/3130
Organism drosophila
Source Curated
MedLine Reference 12865341:1383
Tissue skeletal muscle
Journal Endocrinology
Journal Reference v144 i8 p3586 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/144/8/3586
Organism rat
Source Curated
MedLine Reference 9314839:1144
Journal Circulation Res
Journal Reference v81 i4 p575 (1997)
Journal Link http://circres.ahajournals.org/cgi/content/full/81/4/575
Organism rat
Source Curated
CellLineName VSM
MedLine Reference 12695541:1175
Journal Mol. Pharm
Journal Reference v63 i5 p1125 (2003)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/63/5/1125
Organism bovine
Source Curated