Regulation :

Effect positive
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:7440-70-2:out-urn:agi-go:0004697::positive:phosphorylation
Entities Ca2+ --+> PKC
References 644
Connectivity 2
MedLine Reference 12067896:10
Sentence Inhibition of calcium-dependent PKC by itself led to induction of NOS.
Organism Rattus norvegicus
MedLine Reference 16391706:12
Sentence Ca2+-dependent PKC is potentially involved in this response.
Tissue epithelia
Organism Rattus norvegicus
MedLine Reference 2018537:1
Sentence PKC can be activated in vitro by phosphatidylserine (PS) plus Ca2+.
Organism Rattus norvegicus
MedLine Reference 9530273:10121
Journal Renal Phys
Journal Reference v274 i3 pF564
Journal Link http://ajprenal.physiology.org/cgi/content/full/274/3/F564
Organism Rattus norvegicus
MedLine Reference 11040245:10132
Journal Hypertension
Journal Reference v36 i4 p617
Journal Link http://hyper.ahajournals.org/cgi/content/full/36/4/617
Organism Rattus norvegicus
MedLine Reference 7493986:10266
Journal J. Biol. Chem
Journal Reference v270 i49 p29469
Journal Link http://www.jbc.org/cgi/content/full/270/49/29469
MedLine Reference 16128807:10131
Journal Eur. J. Biochem
Journal Reference v272 i17 p4372
Journal Link http://content.febsjournal.org/cgi/content/full/272/17/4372
Organism Mus musculus
MedLine Reference 15173175:10259
Journal J. Biol. Chem
Journal Reference v279 i31 p32308
Journal Link http://www.jbc.org/cgi/content/full/279/31/32308
Organism Rattus norvegicus
MedLine Reference 9841924:10250
Journal J. Exp. Med
Journal Reference v188 i11 p2099
Journal Link http://www.jem.org/cgi/content/full/188/11/2099
Organism Mus musculus
MedLine Reference 10993750:10038
Journal Heart Circul
Journal Reference v279 i3 pH916
Journal Link http://ajpheart.physiology.org/cgi/content/full/279/3/H916
MedLine Reference 8702475:10015
Journal J. Biol. Chem
Journal Reference v271 i31 p18342
Journal Link http://www.jbc.org/cgi/content/full/271/31/18342
MedLine Reference 10799559:10021
Journal J. Biol. Chem
Journal Reference v275 i19 p14708
Journal Link http://www.jbc.org/cgi/content/full/275/19/14708
Organism Mus musculus
MedLine Reference 11832328:10152
Journal Cell Phys
Journal Reference v282 i3 pC434
Journal Link http://ajpcell.physiology.org/cgi/content/full/282/3/C434
Organism Rattus norvegicus
MedLine Reference 11287324:10165
Journal Cell Phys
Journal Reference v280 i5 pC1114
Journal Link http://ajpcell.physiology.org/cgi/content/full/280/5/C1114
Organism Mus musculus
MedLine Reference 10469124:10027
Journal Eur. J. Biochem
Journal Reference v263 i3 p612
Journal Link http://www.ejbiochem.org/cgi/content/full/263/3/612
Organism Mus musculus
MedLine Reference 9458738:10024
Journal Cell Phys
Journal Reference v274 i1 pC282
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/1/C282
Organism Mus musculus
MedLine Reference 11701424:10052
Journal Endocrin. Metabol
Journal Reference v281 i6 pE1122
Journal Link http://ajpendo.physiology.org/cgi/content/full/281/6/E1122
MedLine Reference 14715933:10400
Organism Rattus norvegicus
MedLine Reference 9774466:10021
Organism Mus musculus
MedLine Reference 7945264:3
Organism Rattus norvegicus
CellType hepatocyte
MedLine Reference 6237101:6
Tissue blood
CellType lymphocyte
MedLine Reference 3194343:1
Organism Mus musculus
MedLine Reference 1651108:1
Organism Rattus norvegicus
MedLine Reference 8621433:5
Organ pancreas
Organism Rattus norvegicus
MedLine Reference 2779522:2
Organism Rattus norvegicus
MedLine Reference 3282960:0
MedLine Reference 3402041:1
Organism Rattus norvegicus
MedLine Reference 12205039:4
Organism Mus musculus
CellLineName HASM
MedLine Reference 10760083:12
Organism Rattus norvegicus
MedLine Reference 8815904:1
Organism Rattus norvegicus
MedLine Reference 2465345:7
CellType basophil
MedLine Reference 2498312:6
CellType neutrophil
MedLine Reference 9547352:10276
Journal Mol. Pharm
Journal Reference v53 i4 p630
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/53/4/630
MedLine Reference 9108098:10158
Journal PNAS
Journal Reference v94 i8 p4022
Journal Link http://www.pnas.org/cgi/content/full/94/8/4022
MedLine Reference 11022047:10027
Journal J. Biol. Chem
Journal Reference v276 i4 p2758
Journal Link http://www.jbc.org/cgi/content/full/276/4/2758
MedLine Reference 12764111:10033
Organism Rattus norvegicus
MedLine Reference 9689015:10039
Journal Renal Phys
Journal Reference v275 i1 pF131
Journal Link http://ajprenal.physiology.org/cgi/content/full/275/1/F131
Organism Mus musculus
MedLine Reference 11356987:10085
Journal Pharm. Rev
Journal Reference v53 i2 p319
Journal Link http://pharmrev.aspetjournals.org/cgi/content/full/53/2/319
Organism Mus musculus
MedLine Reference 8621384:10031
Journal J. Biol. Chem
Journal Reference v271 i10 p5325
Journal Link http://www.jbc.org/cgi/content/full/271/10/5325
Organism Mus musculus
MedLine Reference 15687260:10040
Journal Genes & Dev
Journal Reference v19 i3 p376
Journal Link http://www.genesdev.org/cgi/content/full/19/3/376
MedLine Reference 7592889:10273
Journal J. Biol. Chem
Journal Reference v270 i44 p26639
Journal Link http://www.jbc.org/cgi/content/full/270/44/26639
Organism Rattus norvegicus
MedLine Reference 11882605:10164
Journal Hypertension
Journal Reference v39 i2 p543
Journal Link http://hyper.ahajournals.org/cgi/content/full/39/2/543
Organism Mus musculus
MedLine Reference 10884438:10175
Journal PNAS
Journal Reference v97 i14 p8157
Journal Link http://www.pnas.org/cgi/content/full/97/14/8157
Organism Mus musculus
MedLine Reference 15067032:10296
Journal J. Exp. Med
Journal Reference v199 i7 p959
Journal Link http://www.jem.org/cgi/content/full/199/7/959
Organism Mus musculus
MedLine Reference 12742831:10129
Journal Heart Circul
Journal Reference v284 i6 pH2277
Journal Link http://ajpheart.physiology.org/cgi/content/full/284/6/H2277
Organism Mus musculus
MedLine Reference 11454567:10137
Journal Heart Circul
Journal Reference v281 i2 pH637
Journal Link http://ajpheart.physiology.org/cgi/content/full/281/2/H637
MedLine Reference 16014375:10222
Journal Cell Sci
Journal Reference v118 i15 p3263
Journal Link http://jcs.biologists.org/cgi/content/full/118/15/3263
Organism Mus musculus
MedLine Reference 11358492:10151
Journal Eur. J. Biochem
Journal Reference v268 i10 p2779
Journal Link http://www.ejbiochem.org/cgi/content/full/268/10/2779
MedLine Reference 9811229:1
Tissue epithelia
CellLineName HNPE
MedLine Reference 1419492:1
Tissue mesangia
Organism Rattus norvegicus
MedLine Reference 2122915:0
MedLine Reference 2503513:2
Organism Rattus norvegicus
MedLine Reference 8906581:5
CellLineName LA-N-1
MedLine Reference 2559978:2
Organism Mus musculus
MedLine Reference 9099812:8
MedLine Reference 9300711:6
MedLine Reference 7654180:3
Organism Rattus norvegicus
CellType cardiomyocyte
MedLine Reference 6218169:3
CellType platelet
MedLine Reference 2211681:1
Organism Rattus norvegicus
MedLine Reference 2494288:3
Tissue thyroid
MedLine Reference 10879655:7
Tissue epithelia
Organism Mus musculus
MedLine Reference 1664739:3
Organ liver
Organism Rattus norvegicus
CellType macrophage
MedLine Reference 12459685:12
Organism Mus musculus
MedLine Reference 3387442:4
Tissue thyroid
MedLine Reference 12183638:10219
Journal JPET
Journal Reference v302 i3 p839
Journal Link http://jpet.aspetjournals.org/cgi/content/full/302/3/839
MedLine Reference 15175337:10027
Journal J. Biol. Chem
Journal Reference v279 i30 p30927
Journal Link http://www.jbc.org/cgi/content/full/279/30/30927
Organism Rattus norvegicus
MedLine Reference 9380760:10039
Journal PNAS
Journal Reference v94 i20 p11067
Journal Link http://www.pnas.org/cgi/content/full/94/20/11067
Organism Mus musculus
MedLine Reference 12639897:10058
Journal Endocrinology
Journal Reference v144 i4 p1164
Journal Link http://endo.endojournals.org/cgi/content/full/144/4/1164
Organism Rattus norvegicus
MedLine Reference 11158984:10168
Journal Heart Circul
Journal Reference v280 i2 pH835
Journal Link http://ajpheart.physiology.org/cgi/content/full/280/2/H835
Organism Mus musculus
MedLine Reference 14693696:10012
Journal Diabetes
Journal Reference v53 i1 p41
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/53/1/41
Organism Mus musculus
MedLine Reference 10636898:10133
Journal J. Biol. Chem
Journal Reference v275 i3 p1959
Journal Link http://www.jbc.org/cgi/content/full/275/3/1959
Organism Mus musculus
MedLine Reference 14975939:10248
Journal AJRCMB
Journal Reference v31 i1 p54
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/31/1/54
Organism Mus musculus
MedLine Reference 15917297:10452
Journal Mol. Biol. Cell
Journal Reference v16 i8 p3552
Journal Link http://www.molbiolcell.org/cgi/content/full/16/8/3552
Organism Mus musculus
MedLine Reference 15677757:10321
Journal Endocrinology
Journal Reference v146 i5 p2285
Journal Link http://endo.endojournals.org/cgi/content/full/146/5/2285
Organism Rattus norvegicus
MedLine Reference 9389505:10099
Journal Endocrinology
Journal Reference v138 i12 p5227
Journal Link http://endo.endojournals.org/cgi/content/full/138/12/5227
Organism Rattus norvegicus
MedLine Reference 12960037:10204
Journal Endocrinology
Journal Reference v144 i10 p4354
Journal Link http://endo.endojournals.org/cgi/content/full/144/10/4354
MedLine Reference 8900190:10019
Journal J. Biol. Chem
Journal Reference v271 i43 p27018
Journal Link http://www.jbc.org/cgi/content/full/271/43/27018
Organism Rattus norvegicus
MedLine Reference 9223552:10023
Journal JPET
Journal Reference v282 i1 p172
Journal Link http://jpet.aspetjournals.org/cgi/content/full/282/1/172
MedLine Reference 9765254:10135
MedLine Reference 12228222:10256
Journal J. Biol. Chem
Journal Reference v277 i47 p45203
Journal Link http://www.jbc.org/cgi/content/full/277/47/45203
Organism Mus musculus
MedLine Reference 2656716:8
MedLine Reference 9073607:9
Organism Rattus norvegicus
CellLineName ROS17/2.8
MedLine Reference 7588728:3
Tissue mesangia
MedLine Reference 2853201:7
MedLine Reference 2163494:6
Organ brain
Organism Rattus norvegicus
MedLine Reference 1591273:3
CellLineName CHIEF
MedLine Reference 9886964:6
CellType osteocyte
MedLine Reference 12397090:5
Organism Rattus norvegicus
CellLineName AB
MedLine Reference 3029813:5
Tissue vascular
Organism Mus musculus
MedLine Reference 10233728:4
CellType macrophage
MedLine Reference 14561742:3
MedLine Reference 7881866:1
MedLine Reference 3581079:0
Organism Rattus norvegicus
MedLine Reference 11841365:7
Tissue hair
Organism Mus musculus
MedLine Reference 2160887:3
Organism Rattus norvegicus
CellLineName Y1
MedLine Reference 9627687:4
MedLine Reference 15020304:10146
Journal Heart Circul
Journal Reference v286 i4 pH1455
Journal Link http://ajpheart.physiology.org/cgi/content/full/286/4/H1455
MedLine Reference 15798205:10276
Journal Mol. Cell. Biol
Journal Reference v25 i8 p3194
Journal Link http://mcb.asm.org/cgi/content/full/25/8/3194
MedLine Reference 8910612:10194
Journal J. Biol. Chem
Journal Reference v271 i46 p29453
Journal Link http://www.jbc.org/cgi/content/full/271/46/29453
Organism Mus musculus
MedLine Reference 9058375:10122
Journal Mol. Endocrin
Journal Reference v11 i3 p281
Journal Link http://mend.endojournals.org/cgi/content/full/11/3/281
Organism Rattus norvegicus
MedLine Reference 11983694:10175
Journal J. Biol. Chem
Journal Reference v277 i27 p24252
Journal Link http://www.jbc.org/cgi/content/full/277/27/24252
Organism Mus musculus
MedLine Reference 12637369:10121
Journal Circulation Res
Journal Reference v92 i7 p809
Journal Link http://circres.ahajournals.org/cgi/content/full/92/7/809
Organism Mus musculus
MedLine Reference 11423489:10184
Journal Diabetes
Journal Reference v50 i7 p1666
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/7/1666
Organism Rattus norvegicus
MedLine Reference 9112405:10202
Journal Endocrinology
Journal Reference v138 i5 p2056
Journal Link http://endo.endojournals.org/cgi/content/full/138/5/2056
Organism Rattus norvegicus
MedLine Reference 9531291:10024
Journal J. Immunol
Journal Reference v160 i7 p3330
Journal Link http://www.jimmunol.org/cgi/content/full/160/7/3330
Organism Mus musculus
MedLine Reference 11418685:10200
Journal J. Immunol
Journal Reference v167 i1 p475
Journal Link http://www.jimmunol.org/cgi/content/full/167/1/475
Organism Rattus norvegicus
MedLine Reference 9009275:10235
Journal EMBO
Journal Reference v16 i1 p143
Journal Link http://emboj.oupjournals.org/cgi/content/full/16/1/143
MedLine Reference 12829427:10102
Journal Heart Circul
Journal Reference v285 i4 pH1684
Journal Link http://ajpheart.physiology.org/cgi/content/full/285/4/H1684
Organism Rattus norvegicus
MedLine Reference 8940015:10016
Journal J. Biol. Chem
Journal Reference v271 i48 p30487
Journal Link http://www.jbc.org/cgi/content/full/271/48/30487
MedLine Reference 10871283:10032
Journal J. Cell Biol
Journal Reference v149 i7 p1433
Journal Link http://www.jcb.org/cgi/content/full/149/7/1433
Organism Mus musculus
MedLine Reference 10444414:10186
Journal Endocrin. Metabol
Journal Reference v277 i2 pE208
Journal Link http://ajpendo.physiology.org/cgi/content/full/277/2/E208
Organism Mus musculus
MedLine Reference 16061647:10273
Journal Cancer Res
Journal Reference v65 i15 p6668
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/65/15/6668
MedLine Reference 3458200:1
Organism Rattus norvegicus
CellLineName PC 12
MedLine Reference 8343150:3
Organ liver
Organism Rattus norvegicus
MedLine Reference 14966022:5
CellType lymphocyte
MedLine Reference 6231284:0
Organ heart
Organism Mus musculus
MedLine Reference 3743115:4
Tissue epithelia
MedLine Reference 3022714:0
MedLine Reference 3082370:2
Organ heart
Organism Mus musculus
MedLine Reference 9823967:3
CellLineName LoVo
MedLine Reference 7589144:0
Organism Mus musculus
MedLine Reference 1656201:4
Organism Rattus norvegicus
CellType cardiomyocyte
MedLine Reference 16182446:1
Tissue cortex
Organism Mus musculus
CellType neural
CellLineName NG
MedLine Reference 7931123:7
Organism Mus musculus
MedLine Reference 2434859:3
CellType neural
MedLine Reference 3096987:4
Organism Rattus norvegicus
MedLine Reference 8086279:1
CellType neutrophil
MedLine Reference 1745442:7
Organ brain
Organism Rattus norvegicus
MedLine Reference 11333276:10009
Journal J. Biol. Chem
Journal Reference v276 i27 p24506
Journal Link http://www.jbc.org/cgi/content/full/276/27/24506
MedLine Reference 10903718:10200
Journal J. Immunol
Journal Reference v165 i3 p1210
Journal Link http://www.jimmunol.org/cgi/content/full/165/3/1210
Organism Mus musculus
MedLine Reference 15138280:10182
Journal J. Biol. Chem
Journal Reference v279 i29 p30326
Journal Link http://www.jbc.org/cgi/content/full/279/29/30326
MedLine Reference 12419708:10121
Journal Cell Phys
Journal Reference v283 i6 pC1621
Journal Link http://ajpcell.physiology.org/cgi/content/full/283/6/C1621
Organism Mus musculus
MedLine Reference 10523389:10065
Journal Hypertension
Journal Reference v34 i4 p943
Journal Link http://hyper.ahajournals.org/cgi/content/full/34/4/943
MedLine Reference 11108282:10200
Journal Endocrinology
Journal Reference v141 i12 p4671
Journal Link http://endo.endojournals.org/cgi/content/full/141/12/4671
MedLine Reference 15550506:10036
Journal Endocrinology
Journal Reference v146 i2 p901
Journal Link http://endo.endojournals.org/cgi/content/full/146/2/901
Organism Mus musculus
MedLine Reference 10567005:10063
Journal Endocrin. Metabol
Journal Reference v277 i5 pE798
Journal Link http://ajpendo.physiology.org/cgi/content/full/277/5/E798
Organism Mus musculus
MedLine Reference 10794661:10073
Journal Cell Phys
Journal Reference v278 i5 pC879
Journal Link http://ajpcell.physiology.org/cgi/content/full/278/5/C879
MedLine Reference 10092607:10037
Journal J. Biol. Chem
Journal Reference v274 i14 p9305
Journal Link http://www.jbc.org/cgi/content/full/274/14/9305
Organism Mus musculus
MedLine Reference 12959990:10195
Journal Endocrinology
Journal Reference v144 i10 p4446
Journal Link http://endo.endojournals.org/cgi/content/full/144/10/4446
Organism Mus musculus
MedLine Reference 15262987:10111
Journal J. Biol. Chem
Journal Reference v279 i37 p39122
Journal Link http://www.jbc.org/cgi/content/full/279/37/39122
Organism Mus musculus
MedLine Reference 15840586:10025
Journal J. Biol. Chem
Journal Reference v280 i25 p24135
Journal Link http://www.jbc.org/cgi/content/full/280/25/24135
Organism Mus musculus
MedLine Reference 15845548:10262
Journal J. Biol. Chem
Journal Reference v280 i25 p24212
Journal Link http://www.jbc.org/cgi/content/full/280/25/24212
Organism Mus musculus
MedLine Reference 9891065:10023
Organism Mus musculus
MedLine Reference 10471415:10348
Journal Pharm. Rev
Journal Reference v51 i3 p465
Journal Link http://pharmrev.aspetjournals.org/cgi/content/full/51/3/465
Organism Mus musculus
MedLine Reference 11418104:9
Organism Rattus norvegicus
MedLine Reference 8103344:1
MedLine Reference 11501184:7
CellType platelet
MedLine Reference 8094920:1
MedLine Reference 8335344:6
CellType neutrophil
MedLine Reference 2683593:0
Tissue bone
Organism Rattus norvegicus
MedLine Reference 14766423:2
MedLine Reference 14981072:6
Organism Mus musculus
MedLine Reference 9041261:8
Tissue gallbladder
MedLine Reference 9226446:5
Organ skin
Organism Mus musculus
CellType neural
MedLine Reference 9553141:0
MedLine Reference 3810566:0
CellType platelet
MedLine Reference 3161729:0
Organism Mus musculus
CellType platelet
MedLine Reference 3030721:4
CellLineName HFA
MedLine Reference 1930260:6
Organism Rattus norvegicus
MedLine Reference 9322156:5
CellType neural
MedLine Reference 131101643:11009
MedLine Reference 14622258:10159
Journal Eur. J. Biochem
Journal Reference v270 i23 p4706
Journal Link http://www.ejbiochem.org/cgi/content/full/270/23/4706
Organism Rattus norvegicus
MedLine Reference 7499427:10267
Journal J. Biol. Chem
Journal Reference v270 i48 p28962
Journal Link http://www.jbc.org/cgi/content/full/270/48/28962
MedLine Reference 10984547:10161
Journal PNAS
Journal Reference v97 i19 p10661
Journal Link http://www.pnas.org/cgi/content/full/97/19/10661
MedLine Reference 11102468:10172
Organism Mus musculus
MedLine Reference 9223568:10016
Journal JPET
Journal Reference v282 i1 p301
Journal Link http://jpet.aspetjournals.org/cgi/content/full/282/1/301
Organism Rattus norvegicus
MedLine Reference 10770799:10030
Journal J. Exp. Med
Journal Reference v191 i8 p1319
Journal Link http://www.jem.org/cgi/content/full/191/8/1319
Organism Mus musculus
MedLine Reference 11682614:10013
Journal Cell Sci
Journal Reference v114 i19 p3557
Journal Link http://jcs.biologists.org/cgi/content/full/114/19/3557
MedLine Reference 11003572:10119
Journal Cell Phys
Journal Reference v279 i4 pC925
Journal Link http://ajpcell.physiology.org/cgi/content/full/279/4/C925
Organism Mus musculus
MedLine Reference 11546796:10176
Journal J. Biol. Chem
Journal Reference v276 i45 p42527
Journal Link http://www.jbc.org/cgi/content/full/276/45/42527
MedLine Reference 11739530:10032
Journal J. Immunol
Journal Reference v167 i12 p7084
Journal Link http://www.jimmunol.org/cgi/content/full/167/12/7084
MedLine Reference 10484335:10038
Journal Cell Phys
Journal Reference v277 i3 pC480
Journal Link http://ajpcell.physiology.org/cgi/content/full/277/3/C480
MedLine Reference 11279236:10191
Journal J. Biol. Chem
Journal Reference v276 i23 p20234
Journal Link http://www.jbc.org/cgi/content/full/276/23/20234