Protein : PPP1R12B
Owner Public
URN urn:agi-llid:4660
Hugo ID 7619
Connectivity 7
Name PPP1R12B
Description protein phosphatase 1, regulatory (inhibitor) subunit 12B (predicted)
Notes Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.
RGD ID 1309287
MGI ID 1916417
Cell Localization Nucleus
Pathway PKC in Myosine regulation
Integrin Signaling
Group Phosphatases
signal transduction
regulation of transcription, DNA-dependent
regulation of muscle contraction
DNA binding
transcription factor activity
enzyme activator activity
GenBank ID NC_000001
NM_032105
NP_115288
NM_002481
NP_002472
NM_032104
NP_115287
NM_032103
NP_115286
NT_004487
NW_926128
AC_000044
AC099336
AF324892
AAK00336
AL356953
CAI15934
CAI15935
AL589762
CAH73374
CAH73375
AB003062
BAA28376
AB007972
AB050641
BAB17610
AB050642
BAB17611
AF324888
AAK00337
AL049388
AL050133
AL117460
BC034430
AAH34430
BC071166
AAH71166
BC110907
AAI10908
O60237
Q5VUK2
Q5VUK3
Q6GQY8
NC_000067
XM_136178
XP_136178
XM_889709
XP_894802
XM_898626
XP_903719
NT_078297
NW_000154
XM_982828
XP_987922
XM_982782
XP_987876
XM_982739
XP_987833
NW_001030662
XM_993949
XP_999043
XM_915582
XP_920675
XM_923816
XP_928909
AC_000023
AC117827
AC131591
AI132431
AK007727
BAB25216
AK039445
AK042847
BAC31381
AK046012
BAC32572
AK046167
BAC32618
AK080855
BAC38046
AK132310
AK141375
AW492237
BG087937
Q8BG95
NC_005112
XM_222656
XP_222656
NW_001084685
XM_001062402
XP_001062402
NW_047395
AC_000081
Source Curated
LocusLink ID 4660
329251
304813
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 603768
Alias MYPT2
MGC87886
MGC131980
protein phosphatase 1, regulatory (inhibitor) subunit 12B
myosin phosphatase, target subunit 2
myosin phosphatase regulatory subunit
AI132431
A330043L12
B230333M12
1810037O03Rik
protein phosphatase 1, regulatory (inhibitor) subunit 12B (predicted)
GO ID 0008047
0006937
0007165
0003677
0003700
0006355
Swiss-Prot Accession O60237
Q5VUK2
Q5VUK3
Q6GQY8
Q8BG95
Unigene ID Hs.444403
Mm.188709
Mm.430827