Protein : TNS1


Owner	Public
URN	urn:agi-llid:7145
Hugo ID	11973
Connectivity	76
Name	TNS1
Description	similar to tensin
Notes	The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.


MGI ID	104552


Cell Localization	Plasma membrane


Pathway	integrin alphaVbeta5
	integrin alphaEbeta7
	integrin alphaVbeta3
	integrin alpha2beta1
	integrin alphaDbeta2
	integrin alpha1beta1
	integrin alpha11beta1
	integrin alpha9beta1
	integrin alpha10beta1
	integrin alphaXbeta2
	integrin alpha8beta1
	integrin alpha7beta1
	integrin alpha6beta1
	integrin alphaVbeta1
	integrin alphaMbeta2
	integrin alpha5beta1
	integrin alphaLbeta2
	integrin alphaVbeta8
	integrin alpha4beta7
	integrin alpha4beta1
	integrin alpha3beta1
	integrin alpha2Bbeta3
	Integrin Signaling


Group	Cytoskeleton
	Ph
	Sh2
	intracellular signaling cascade
	cell migration
	cell-substrate junction assembly
	cytoskeleton
	cell-matrix junction
	focal adhesion
	actin binding


GenBank ID	NC_000002
	NM_022648
	NP_072174
	NT_005403
	NW_921618
	AC_000045
	AB209238
	BAD92475
	AF116610
	AAF71035
	AK001785
	BAA91910
	AL117537
	CAB55983
	BC014042
	AAH14042
	BC033065
	BC051304
	AAH51304
	BC071905
	AAH71905
	BC116187
	AAI16188
	BC116188
	AAI16189
	BE142921
	Q4ZG71
	Q59G71
	Q6IPI5
	Q6PJM3
	Q86VB0
	Q9H757
	Q9HBL0
	Q9NV48
	Q9P1L6
	Q9UFN8
	NC_000067
	XM_619639
	XP_619639
	NT_039170
	NW_000166
	XM_991946
	XP_997040
	NW_001030680
	XM_984786
	XP_989880
	AC_000023
	AC116419
	AC117757
	AA000420
	AI648117
	AK003780
	AK004758
	BAB23539
	AK053112
	BAC35268
	AK086989
	AK087187
	AK087231
	BAC39825
	AK137923
	AK156648
	BAE33792
	AW122767
	BC026430
	BC037471
	BC052740
	AAH52740
	BC055076
	AAH55076
	BI101050
	Q7TPM8
	Q9DBT6
	NC_005108
	XM_237286
	XP_237286
	NW_047816


Source	Curated


LocusLink ID	7145
	21961
	301509


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	600076


Alias	TNS
	MGC88584
	tensin
	AI648117
	1110018I21Rik
	1200014E20Rik
	E030018G17Rik
	E030037J05Rik
	tensin 1
	LOC301509
	similar to tensin


GO ID	0003779
	0007242
	0005856
	0016477
	0007044
	0030055
	0005925


Swiss-Prot Accession	Q4ZG71
	Q59G71
	Q6IPI5
	Q6PJM3
	Q86VB0
	Q9H757
	Q9HBL0
	Q9NV48
	Q9P1L6
	Q9UFN8
	Q7TPM8
	Q9DBT6


Unigene ID	Hs.471381
	Mm.309975