Protein : MAP2K2


Owner	Public
URN	urn:agi-llid:5605
Hugo ID	6842
Connectivity	600
Name	MAP2K2
Description	mitogen activated protein kinase kinase 2
Notes	a dual-specificity protein kinase that activates the Erk1 and Erk2 kinases [RGD]


RGD ID	61888


MGI ID	1346867


Pathway	p40 MAPK
	Insulin Receptor Signaling
	MAPK-ERK in Growth and Differentiation
	G-protein Coupled Receptor signaling
	Integrin Signaling
	AGTR1 -> ELK1-SRF signaling pathway
	Notch -> CREB1 signaling pathway
	PTPRC -> BCL6 signaling pathway
	Notch -> ELK1-SRF signaling pathway
	AGTR1 -> ELK4-SRF signaling pathway
	Notch -> ELK4-SRF signaling pathway
	Notch -> TCF3 signaling pathway
	EDG2 -> ELK4-SRF signaling pathway
	EDG3/5 -> AP-1 signaling pathway
	AGTR1 -> TP53 signaling pathway
	TNFRSF6 -> HSF1 signaling pathway
	AGTR2 -> CREB1 signaling pathway
	EDG3/5 -> ELK1-SRF signaling pathway
	VIPR1 -> CEBPB signaling pathway
	EDG3/5 -> ELK4-SRF signaling pathway
	EGFR -> AP-1 signaling pathway
	AGTR2 -> ELK1-SRF signaling pathway
	AGTR2 -> ELK4-SRF signaling pathway
	NTRKs -> AP-1 signaling pathway
	NTRKs -> CREB1 signaling pathway
	VIPR1 -> CEBPD signaling pathway
	NTRKs -> ELK1-SRF signaling pathway
	NTRKs -> ELK4-SRF signaling pathway
	AGTR2 -> TP53 signaling pathway
	ERBB2 -> ETV4 signaling pathway
	EGFR -> ATF2 signaling pathway
	EGFR -> SMAD1 signaling pathway
	NTRKs -> MYC signaling pathway
	NTRKs -> STAT5A signaling pathway
	VIPR1 -> CREB1 signaling pathway
	NTRKs -> TP53 signaling pathway
	OPRs -> CREB1 signaling pathway
	IGF1R -> ELK1-SRF signaling pathway
	B-cell receptor -> AP-1 signaling pathway
	EGFR/ERBB2 -> HIF1A signaling pathway
	ERBB2/3 -> SP1 signaling pathway
	IGF1R -> ELK4-SRF signaling pathway
	OPRs -> ELK1-SRF signaling pathway
	IGF1R -> HIF1A signaling pathway
	OPRs -> ELK4-SRF signaling pathway
	IGF1R -> MYC signaling pathway
	OPRs -> STAT3 signaling pathway
	IGF1R -> SREBF1 signaling pathway
	EGFR/ERBB2 -> TP53 signaling pathway
	F2R -> AP-1 signaling pathway
	PECAM1 -> SP1 signaling pathway
	ENDRA -> AP-1 signaling pathway
	PLAUR -> ELK1-SRF signaling pathway
	RET -> HSF1 signaling pathway
	PLAUR -> ELK4-SRF signaling pathway
	ENDRA -> CREB1 signaling pathway
	ENDRB -> AP-1 signaling pathway
	F2R -> CREB1 signaling pathway
	ENDRB -> CREB1 signaling pathway
	ENDRB -> ELK1-SRF signaling pathway
	F2R -> ELK1-SRF signaling pathway
	ENDRB -> ELK4-SRF signaling pathway
	F2R -> ELK4-SRF signaling pathway
	PTAFR -> AP-1 signaling pathway
	F2R -> SP1 signaling pathway
	PTAFR -> ATF1 signaling pathway
	PTAFR -> CREB1 signaling pathway
	PTAFR -> ELK1-SRF signaling pathway
	PTAFR -> ELK4-SRF signaling pathway
	EPOR -> ELK1-SRF signaling pathway
	PTGFR -> CREB1 signaling pathway
	EPOR -> ELK4-SRF signaling pathway
	SELE -> ELK1-SRF signaling pathway
	IL1R -> NF-kB signaling pathway
	EPOR -> FOS signaling pathway
	PTGFR -> ELK1-SRF signaling pathway
	FCGR3A -> ELK1-SRF signaling pathway
	PTGFR -> ELK4-SRF signaling pathway
	PTGFR -> MYC signaling pathway
	CCKAR -> ELK1-SRF signaling pathway
	PTGFR -> TCF3 signaling pathway
	SELE -> ELK4-SRF signaling pathway
	CCKAR -> ELK4-SRF signaling pathway
	PTGIR -> ATF1 signaling pathway
	CCKBR -> ELK1-SRF signaling pathway
	FCGR3A -> ELK4-SRF signaling pathway
	CCKBR -> ELK4-SRF signaling pathway
	ERBB2 -> EP300 signaling pathway
	ERBB2 -> ETS1 signaling pathway
	PTGIR -> CREB1 signaling pathway
	PTGIR -> ELK1-SRF signaling pathway
	ERBB2 -> ETS2 signaling pathway
	PTGIR -> ELK4-SRF signaling pathway
	PTGIR -> MYC signaling pathway
	ERBB2 -> ETV1 signaling pathway
	IL2R -> ELK1-SRF signaling pathway
	IL2R -> ELK4-SRF signaling pathway
	IL2R -> MYC signaling pathway
	T-cell receptor -> AP-1 signaling pathway
	IL4R -> ELK1-SRF signaling pathway
	CD19 -> AP-1 signaling pathway
	IL4R -> ELK4-SRF signaling pathway
	IL4R -> HMGY signaling pathway
	CD19 -> ELK1-SRF signaling pathway
	CD19 -> ELK4-SRF signaling pathway
	TACR1 -> ELK1-SRF signaling pathway
	IL6R -> CEBPB signaling pathway
	FGFRs -> RUNX2 signaling pathway
	IL6R -> ELK1-SRF signaling pathway
	IL6R -> ELK4-SRF signaling pathway
	CD22/72 -> AP-1 signaling pathway
	TACR1 -> ELK4-SRF signaling pathway
	TBXA2R -> CREB1 signaling pathway
	INSR -> ELK1-SRF signaling pathway
	INSR -> ELK4-SRF signaling pathway
	ADORA1 -> AP-1 signaling pathway
	INSR -> SREBF1 signaling pathway
	INSR -> SREBF2 signaling pathway
	FSHR -> CREB1 signaling pathway
	FSHR -> ELK1-SRF signaling pathway
	FSHR -> ELK4-SRF signaling pathway
	ITGB1 -> AP-1 signaling pathway
	FSHR -> GATA4 signaling pathway
	CD38 -> AP-1 signaling pathway
	GCGR -> CREB1 signaling pathway
	ITGB1 -> ELK1-SRF signaling pathway
	CD38 -> CEBPA signaling pathway
	ITGB1 -> ELK4-SRF signaling pathway
	CD38 -> CREB1 signaling pathway
	CD38 -> ELK1-SRF signaling pathway
	CD38 -> ELK4-SRF signaling pathway
	ITGB1 -> SREBF1 signaling pathway
	GCGR -> ELK1-SRF signaling pathway
	CD38 -> MYC signaling pathway
	GCGR -> ELK4-SRF signaling pathway
	ITGB1 -> SREBF2 signaling pathway
	GCGR -> SP1 signaling pathway
	KDR -> ATF1 signaling pathway
	GFRs -> AP-1 signaling pathway
	GFRs -> CREB1 signaling pathway
	GFRs -> CREBBP signaling pathway
	CD38 -> TCF3 signaling pathway
	GFRs -> ELK1-SRF signaling pathway
	ADRA1B -> ELK1-SRF signaling pathway
	KDR -> ATF2 signaling pathway
	GFRs -> ELK4-SRF signaling pathway
	KDR -> CREB1 signaling pathway
	CHRM1 -> CREB1 signaling pathway
	GFRs -> MYC signaling pathway
	KDR -> ELK1-SRF signaling pathway
	KDR -> ELK4-SRF signaling pathway
	KIT -> MITF signaling pathway
	GHR -> ELK1-SRF signaling pathway
	CHRM1 -> ELK1-SRF signaling pathway
	CHRM1 -> ELK4-SRF signaling pathway
	CHRNA7 -> CREB1 signaling pathway
	ADRA1B -> ELK4-SRF signaling pathway
	GHR -> ELK4-SRF signaling pathway
	GHR -> MYC signaling pathway
	LEPR -> ELK1-SRF signaling pathway
	ADRA1B -> STAT3 signaling pathway
	CNRs -> CREB1 signaling pathway
	TNFRs -> AP-1 signaling pathway
	LEPR -> ELK4-SRF signaling pathway
	CNRs -> ELK1-SRF signaling pathway
	CNRs -> ELK4-SRF signaling pathway
	ADRB1 -> STAT3 signaling pathway
	GNRHR -> ELK1-SRF signaling pathway
	GNRHR -> ELK4-SRF signaling pathway
	GRIN1 -> CREB1 signaling pathway
	ADRB2 -> CREB1 signaling pathway
	GRM1/5 -> CREB1 signaling pathway
	MPL -> CREB1 signaling pathway
	ADRB2 -> STAT3 signaling pathway
	MPL -> SP1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	HTR2A -> ELK1-SRF signaling pathway
	TNFRs -> CREB1 signaling pathway
	ADRB3 -> STAT3 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	HTR2A -> ELK4-SRF signaling pathway
	AGER -> CREB1 signaling pathway
	NCAM1 -> CREB1 signaling pathway
	NCAM1 -> ELK1-SRF signaling pathway
	NCAM1 -> ELK4-SRF signaling pathway
	DRD1 -> CREB1 signaling pathway
	HTR2A -> GATA4 signaling pathway
	NCAM1 -> MYC signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRs -> TP53 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	ICAM1 -> CREB1 signaling pathway
	DRD1 -> ELK1-SRF signaling pathway
	DRD1 -> ELK4-SRF signaling pathway
	TNFRSF1A -> ATF2 signaling pathway
	DRD2 -> AP-1 signaling pathway
	TNFRSF1A -> CREB1 signaling pathway
	ICAM1 -> ELK1-SRF signaling pathway
	NGFR -> CEBPB signaling pathway
	TNFRSF1A -> ELK1-SRF signaling pathway
	NGFR -> CREB1 signaling pathway
	ICAM1 -> ELK4-SRF signaling pathway
	NGFR -> ELK1-SRF signaling pathway
	TNFRSF1A -> ELK4-SRF signaling pathway
	NGFR -> ELK4-SRF signaling pathway
	ICAM1 -> MYC signaling pathway
	DRD2 -> CREB1 signaling pathway
	NGFR -> TP53 signaling pathway
	DRD2 -> ELK1-SRF signaling pathway
	AGER -> SP1 signaling pathway
	AGTR1 -> CREB1 signaling pathway
	TNFRSF1A -> TP53 signaling pathway
	DRD2 -> ELK4-SRF signaling pathway
	EDARs -> AP-1 signaling pathway
	EDG2 -> ELK1-SRF signaling pathway
	tshirt 'Insulin Receptor Signaling' 1


Group	Kinases
	protein amino acid phosphorylation
	extracellular region
	nucleotide binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity


GenBank ID	NC_000019
	NM_030662
	NP_109587
	NT_011255
	NW_927173
	AC_000062
	AC016586
	AK093125
	BC000471
	AAH00471
	BC018645
	AAH18645
	BX538081
	CAD98005
	CR609681
	CR615045
	CR617539
	L11285
	P36507
	Q7Z370
	NC_000076
	NM_023138
	NP_075627
	NT_039500
	NW_000028
	XM_987766
	XP_992860
	NW_001030416
	AC_000032
	AC155932
	AK009392
	BAB26261
	AK036822
	BAC29592
	AK080574
	BAC37945
	AK138130
	AK140101
	BAE24237
	AK143425
	BAE25372
	AK171584
	BAE42542
	AK172055
	BAE42803
	AK176974
	AK186012
	AK192399
	AK202988
	AK203356
	AK208021
	AK212487
	AK216389
	AK217783
	AW553456
	BC014830
	AAH14830
	BG074492
	S68267
	AAC60678
	Q63932
	Q8CB46
	Q91YS7
	Q9D7B0
	NC_005106
	NM_133283
	NP_579817
	NW_001084852
	NW_047773
	AC_000075
	D14592
	BAA03442
	L14936
	AAA41620
	P36506


Source	Curated


LocusLink ID	5605
	26396
	58960


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	601263
	115150


Alias	MEK2
	MKK2
	MAPKK2
	PRKMK2
	mitogen-activated protein kinase kinase 2
	CFC syndrome
	MAPK/ERK kinase 2
	MAP kinase kinase 2
	ERK activator kinase 2
	cardiofaciocutaneous syndrome
	mitogen-activated protein kinase kinase 2, p45
	dual specificity mitogen-activated protein kinase kinase 2
	MK2
	AA589381
	mitogen activated protein kinase kinase 2
	MAP kinase/Erk kinase
	protein kinase, mitogen activated, kinase 2, p45


GO ID	0005524
	0000166
	0004674
	0004713
	0016740
	0006468
	0005576
	0016301
	0004672


Swiss-Prot Accession	P36507
	Q7Z370
	Q63932
	Q8CB46
	Q91YS7
	Q9D7B0
	P36506


Unigene ID	Hs.465627
	Mm.275436
	Rn.82693