Protein : GRF2
Owner Public
URN urn:agi-llid:2889
Hugo ID 4568
Connectivity 194
Name GRF2
Description Rap guanine nucleotide exchange factor (GEF) 1
Notes The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor-type Src homology (SH)2-containing molecules. Src homology 2 domains are globular protein modules present in a large variety of functionally distinct proteins. They mediate binding events that control the activity and localization of many proteins involved in the transmission of signals from the cell surface to the nucleus. The mRNAs of these proteins are expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Cell Localization Plasma membrane
Pathway Insulin Receptor Signaling
MAPK-ERK in Growth and Differentiation
Integrin Signaling
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
ITGB1 -> SREBF2 signaling pathway
Group Gtpase regulators
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of small GTPase mediated signal transduction
intracellular
protein binding
guanyl-nucleotide exchange factor activity
GenBank ID NC_000009
NM_005312
NP_005303
NM_198679
NP_941372
NT_035014
NW_924573
AC_000052
AL160271
CAI13381
CAI13382
CAI13383
AL160276
CAI40645
CAI40646
CAI40647
CAI40651
AF467069
AAP97718
AJ420417
AK023727
AK023760
BC041710
AAH41710
BG429001
BG546427
BQ054243
BQ772947
CR749354
CAH18207
D21239
BAA04770
Q13905
Q5JUE6
Q5T8F6
Q5T8F7
Q68DL3
Q7Z4P7
Q8IV73
Source Curated
LocusLink ID 2889
Organism Homo sapiens
OMIM ID 600303
Alias C3G
GRF2
DKFZp781P1719
guanine nucleotide-releasing factor 2
OTTHUMP00000064558
guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
GO ID 0005085
0005515
0051056
0007165
0007169
0005622
Swiss-Prot Accession Q13905
Q5JUE6
Q5T8F6
Q5T8F7
Q68DL3
Q7Z4P7
Q8IV73
Unigene ID Hs.127897