Protein : RAP1A
Owner Public
URN urn:agi-llid:5906
Hugo ID 9855
Connectivity 149
Name RAP1A
Description RAS-related protein 1a
Notes The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
RGD ID 1359694
MGI ID 97852
Pathway p40 MAPK
MAPK-ERK in Growth and Differentiation
G-protein Coupled Receptor signaling
Integrin Signaling
AGTR1 -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
AGTR1 -> TP53 signaling pathway
AGTR2 -> CREB1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
VIPR1 -> CEBPD signaling pathway
AGTR2 -> TP53 signaling pathway
VIPR1 -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
PTGIR -> ATF1 signaling pathway
PTGIR -> CREB1 signaling pathway
PTGIR -> ELK1-SRF signaling pathway
PTGIR -> ELK4-SRF signaling pathway
PTGIR -> MYC signaling pathway
TACR1 -> ELK1-SRF signaling pathway
TACR1 -> ELK4-SRF signaling pathway
TBXA2R -> CREB1 signaling pathway
FSHR -> CREB1 signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> AP-1 signaling pathway
FSHR -> GATA4 signaling pathway
GCGR -> CREB1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
GCGR -> ELK1-SRF signaling pathway
GCGR -> ELK4-SRF signaling pathway
ITGB1 -> SREBF2 signaling pathway
GCGR -> SP1 signaling pathway
CHRM1 -> CREB1 signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
CNRs -> CREB1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
ADRB1 -> STAT3 signaling pathway
GRIN1 -> CREB1 signaling pathway
ADRB2 -> CREB1 signaling pathway
GRM1/5 -> CREB1 signaling pathway
ADRB2 -> STAT3 signaling pathway
ADRB3 -> STAT3 signaling pathway
DRD1 -> CREB1 signaling pathway
ICAM1 -> CREB1 signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
ICAM1 -> MYC signaling pathway
AGTR1 -> CREB1 signaling pathway
Group Gtp binding proteins
small GTPase mediated signal transduction
cell cycle
negative regulation of progression through cell cycle
intracellular
membrane
nucleotide binding
protein binding
GTP binding
GTPase activity
GenBank ID NC_000001
NM_001010935
NP_001010935
NM_002884
NP_002875
NT_019273
NW_922462
AC_000044
A08691
CAA00804
AL049557
CAB55685
CAI22712
AL139012
AB051846
BAB61868
AF493912
AAM12626
BC014086
AAH14086
BI460853
BT019666
AAV38472
BU150941
CR597469
CR623933
M22995
AAA36150
X12533
CAA31051
P62834
Q5QPH6
Q5U0C3
NC_000069
NM_145541
NP_663516
NT_039240
NW_000200
NW_001030731
AC_000025
AC139316
AA210264
AK030897
BAE20461
AK152504
BAE31271
BC051419
AAH51419
BC083128
AAH83128
BG068432
P62835
NC_005101
NM_001005765
NP_001005765
NW_001084807
NW_047627
AC_000070
BC083813
AAH83813
D88312
BAA20126
O08813
P62836
Source Curated
LocusLink ID 5906
109905
295347
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 179520
Alias RAP1
KREV1
KREV-1
SMGP21
RAP1A, member of RAS oncogene family
OTTHUMP00000059089
RAS-related protein RAP1A
Ras-related protein Krev-1
G-22K
AI848598
MGC102329
RAS-related protein-1a
GTP-binding protein SMG-P21A
RAP-1A
rap 1A
MGC94873
Ras-related protein RAP-1A
GO ID 0005525
0000166
0005515
0007049
0045786
0007264
0005622
0016020
0003924
Swiss-Prot Accession P62834
Q5QPH6
Q5U0C3
P62835
O08813
P62836
Unigene ID Hs.190334
Mm.365961
Rn.106321