Protein : VCL
Owner Public
URN urn:agi-llid:7414
Hugo ID 12665
Connectivity 277
Name VCL
Description vinculin (predicted)
Notes Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Human vinculin protein exhibits a greater than 95% sequence identity to the chicken vinculin protein.
RGD ID 1311217
MGI ID 98927
Cell Localization Plasma membrane
Pathway integrin alphaVbeta5
integrin alphaVbeta3
integrin alpha2beta1
integrin alphaDbeta2
integrin alpha1beta1
integrin alpha11beta1
integrin alpha9beta1
integrin alpha10beta1
integrin alphaXbeta2
integrin alpha8beta1
integrin alpha7beta1
integrin alpha6beta1
integrin alphaVbeta1
integrin alphaMbeta2
integrin alpha5beta1
integrin alphaLbeta2
integrin alphaVbeta8
integrin alpha4beta7
integrin alpha4beta1
integrin alpha3beta1
integrin alpha2Bbeta3
Integrin Signaling
Group Cytoskeleton
cell adhesion
cell motility
regulation of cell migration
negative regulation of cell migration
lamellipodium biogenesis
apical junction assembly
metabolism
protein complex
costamere
cytoskeleton
actin cytoskeleton
cell-matrix junction
focal adhesion
adherens junction
intercellular junction
structural molecule activity
protein binding
alpha-catenin binding
actin binding
oxidoreductase activity
GenBank ID NC_000010
NM_014000
NP_054706
NM_003373
NP_003364
NT_008583
NW_924796
AC_000053
AL596247
CAI13972
AL731576
CAI39669
CAI39673
L04933
AAA61271
S87180
AAB21656
S87223
AAB21657
AA368699
AI290052
AK126978
AL700886
AL708715
AL832130
BC013847
BC039174
AAH39174
BX537994
CAD97952
M33308
AAA61283
P18206
Q5JQ13
Q5SWX2
NC_000080
NM_009502
NP_033528
NT_039596
NW_000089
NW_001030542
AC_000036
AC154840
AC163681
L13299
AAA40557
L13300
AB041262
BAB16378
AI385712
AK035184
BAC28973
AK077850
BAC37033
BC008520
AAH08520
BC008554
AAH08554
BG063694
L18880
AAB96843
Q64727
Q9ESQ3
NC_005114
XM_223781
XP_223781
NW_001084696
XM_001057629
XP_001057629
NW_047445
AC_000083
Source Curated
LocusLink ID 7414
22330
305679
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 193065
Alias MVCL
RP11-178G16.3
vinculin
OTTHUMP00000043885
AA571387
AI462105
AW545629
9430097D22
metavinculin
vinculin (predicted)
GO ID 0003779
0045294
0016491
0005198
0043297
0007155
0006928
0030032
0030336
0015629
0005912
0030055
0043034
0005925
0005911
0043234
0005515
0008152
0030334
0005856
Swiss-Prot Accession P18206
Q5JQ13
Q5SWX2
Q64727
Q9ESQ3
Unigene ID Hs.500101
Mm.279361