Protein : TLN1


Owner	Public
URN	urn:agi-llid:7094
Hugo ID	11845
Connectivity	181
Name	TLN1
Description	talin 1
Notes	This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.


RGD ID	1306247


MGI ID	1099832


Cell Localization	Plasma membrane


Pathway	integrin alphaVbeta5
	integrin alphaVbeta3
	integrin alpha2beta1
	integrin alphaDbeta2
	integrin alpha1beta1
	integrin alpha11beta1
	integrin alpha9beta1
	integrin alpha10beta1
	integrin alphaXbeta2
	integrin alpha8beta1
	integrin alpha7beta1
	MAPK-ERK in Growth and Differentiation
	integrin alpha6beta1
	integrin alphaVbeta1
	integrin alphaMbeta2
	integrin alpha5beta1
	integrin alphaLbeta2
	integrin alphaVbeta8
	integrin alpha4beta7
	Erk-PI3K in Collagen Binding
	integrin alpha4beta1
	integrin alpha3beta1
	integrin alpha2Bbeta3
	Integrin Signaling


Group	Cytoskeleton
	cell motility
	cell-substrate junction assembly
	intercellular junction assembly
	cytoskeletal anchoring
	cortical actin cytoskeleton organization and biogenesis
	ruffle
	cytosol
	cytoskeleton
	focal adhesion
	intercellular junction
	binding
	structural molecule activity
	protein binding
	actin binding
	vinculin binding
	LIM domain binding
	structural constituent of cytoskeleton


Source	Curated


OMIM ID	186745