Protein : PTK2


Owner	Public
URN	urn:agi-llid:5747
Hugo ID	9611
Connectivity	1406
Name	PTK2
Description	PTK2 protein tyrosine kinase 2
Notes	tyrosine kinase that is enriched in focal adhesions; may regulate mechanical signal transduction in cardiac myocytes [RGD]


RGD ID	3443


MGI ID	95481


Pathway	integrin alphaVbeta5
	integrin alphaEbeta7
	integrin alphaVbeta3
	integrin alpha2beta1
	integrin alphaDbeta2
	integrin alpha1beta1
	integrin alpha11beta1
	integrin alpha9beta1
	integrin alpha10beta1
	ACH-R in apoptosis
	integrin alphaXbeta2
	integrin alpha8beta1
	integrin alpha7beta1
	MAPK-ERK in Growth and Differentiation
	integrin alpha6beta1
	PTEN signaling
	integrin alphaVbeta1
	integrin alphaMbeta2
	integrin alpha5beta1
	EPHA2
	integrin alphaLbeta2
	integrin alphaVbeta8
	integrin alpha4beta7
	Erk-PI3K in Collagen Binding
	integrin alpha4beta1
	integrin alpha3beta1
	integrin alpha2Bbeta3
	Integrin Signaling
	ITGB1 -> AP-1 signaling pathway
	ITGB1 -> CTNNB1 signaling pathway
	ITGB1 -> ELK1-SRF signaling pathway
	ITGB1 -> ELK4-SRF signaling pathway
	ITGB1 -> NF-kB signaling pathway
	ITGB1 -> SREBF1 signaling pathway
	ITGB1 -> SREBF2 signaling pathway
	KDR -> CTNNB1 signaling pathway
	KDR -> STAT1 signaling pathway
	KDR -> STAT3 signaling pathway
	CHRNA7 -> CREB1 signaling pathway
	NCAM1 -> CREB1 signaling pathway
	NCAM1 -> ELK1-SRF signaling pathway
	NCAM1 -> ELK4-SRF signaling pathway
	NCAM1 -> MYC signaling pathway
	ACH-R in apoptosis'-2


Group	Kinases
	integrin-mediated signaling pathway
	neuron migration
	cell motility
	extracellular matrix organization and biogenesis
	establishment of nucleus localization
	microtubule cytoskeleton organization and biogenesis
	protein amino acid phosphorylation
	blood vessel development
	negative regulation of organ size
	lamellipodium
	cytoskeleton
	focal adhesion
	binding
	nucleotide binding
	protein binding
	ATP binding
	SH2 domain binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity


Source	Curated


OMIM ID	600758


Alias	FAK
	FADK
	FAK1
	pp125FAK
	PTK2 protein tyrosine kinase 2
	focal adhesion kinase 1
	FRNK
	KIAA4203
	mKIAA4203
	focal adhesion kinase
	Protein tyrosine kinase
	protein tyrosine kinase 2
	focal adhesion kinase-related nonkinase