Protein : MAPK3
Owner Public
URN urn:agi-llid:5595
Hugo ID 6877
Connectivity 3535
Name MAPK3
Description mitogen activated protein kinase 3
Notes kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD]
RGD ID 3046
MGI ID 1346859
Cell Localization Nucleus
Pathway p40 MAPK
TGF-beta signaling
Antiapoptotic Pathways From IGF-1R
Mitochondrial control of Apoptosis
MAPK-ERK in Growth and Differentiation
Inhibition of Apoptosis
G-protein Coupled Receptor signaling
CREB signaling
Erk-PI3K in Collagen Binding
Apoptosis
Integrin Signaling
AGTR1 -> ELK1-SRF signaling pathway
Notch -> CREB1 signaling pathway
PTPRC -> BCL6 signaling pathway
Notch -> ELK1-SRF signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
Notch -> ELK4-SRF signaling pathway
Notch -> TCF3 signaling pathway
EDG2 -> ELK4-SRF signaling pathway
EDG3/5 -> AP-1 signaling pathway
AGTR1 -> TP53 signaling pathway
TNFRSF6 -> HSF1 signaling pathway
AGTR2 -> CREB1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
VIPR1 -> CEBPD signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
AGTR2 -> TP53 signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
VIPR1 -> CREB1 signaling pathway
NTRKs -> TP53 signaling pathway
OPRs -> CREB1 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
B-cell receptor -> AP-1 signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
OPRs -> ELK4-SRF signaling pathway
IGF1R -> MYC signaling pathway
OPRs -> STAT3 signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
PECAM1 -> SP1 signaling pathway
ENDRA -> AP-1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
ENDRA -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
F2R -> SP1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
PTGFR -> CREB1 signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
IL1R -> NF-kB signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
PTGFR -> ELK4-SRF signaling pathway
PTGFR -> MYC signaling pathway
CCKAR -> ELK1-SRF signaling pathway
PTGFR -> TCF3 signaling pathway
SELE -> ELK4-SRF signaling pathway
CCKAR -> ELK4-SRF signaling pathway
PTGIR -> ATF1 signaling pathway
CCKBR -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
CCKBR -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
PTGIR -> CREB1 signaling pathway
PTGIR -> ELK1-SRF signaling pathway
ERBB2 -> ETS2 signaling pathway
PTGIR -> ELK4-SRF signaling pathway
PTGIR -> MYC signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
T-cell receptor -> AP-1 signaling pathway
IL4R -> ELK1-SRF signaling pathway
CD19 -> AP-1 signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
CD19 -> ELK1-SRF signaling pathway
CD19 -> ELK4-SRF signaling pathway
TACR1 -> ELK1-SRF signaling pathway
FGFRs -> RUNX2 signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
CD22/72 -> AP-1 signaling pathway
TACR1 -> ELK4-SRF signaling pathway
TBXA2R -> CREB1 signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
ADORA1 -> AP-1 signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
FSHR -> CREB1 signaling pathway
FSHR -> ELK1-SRF signaling pathway
FSHR -> ELK4-SRF signaling pathway
ITGB1 -> AP-1 signaling pathway
FSHR -> GATA4 signaling pathway
CD38 -> AP-1 signaling pathway
GCGR -> CREB1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
CD38 -> CEBPA signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
CD38 -> CREB1 signaling pathway
CD38 -> ELK1-SRF signaling pathway
CD38 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
GCGR -> ELK1-SRF signaling pathway
CD38 -> MYC signaling pathway
GCGR -> ELK4-SRF signaling pathway
ITGB1 -> SREBF2 signaling pathway
GCGR -> SP1 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
CD38 -> TCF3 signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
LEPR -> ELK1-SRF signaling pathway
CNRs -> CREB1 signaling pathway
TNFRs -> AP-1 signaling pathway
LEPR -> ELK4-SRF signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
ADRB1 -> STAT3 signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
GRIN1 -> CREB1 signaling pathway
ADRB2 -> CREB1 signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
ADRB2 -> STAT3 signaling pathway
MPL -> SP1 signaling pathway
TNFRs -> ATF2 signaling pathway
HTR2A -> ELK1-SRF signaling pathway
TNFRs -> CREB1 signaling pathway
ADRB3 -> STAT3 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
HTR2A -> ELK4-SRF signaling pathway
AGER -> CREB1 signaling pathway
NCAM1 -> CREB1 signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
DRD1 -> CREB1 signaling pathway
HTR2A -> GATA4 signaling pathway
NCAM1 -> MYC signaling pathway
NGFR -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
ICAM1 -> CREB1 signaling pathway
DRD1 -> ELK1-SRF signaling pathway
DRD1 -> ELK4-SRF signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
NGFR -> CEBPB signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
ICAM1 -> ELK4-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
ICAM1 -> MYC signaling pathway
DRD2 -> CREB1 signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> SP1 signaling pathway
AGTR1 -> CREB1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDARs -> AP-1 signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Aquaporin
Copy of 'Apoptosis'
Apoptosis2
Group Kinases
signal transduction
intracellular signaling cascade
protein kinase cascade
nuclear translocation of MAPK
cell cycle
regulation of progression through cell cycle
protein amino acid phosphorylation
positive regulation of transcription
phosphorylation
organ morphogenesis
response to DNA damage stimulus
cellular_component
insoluble fraction
cytoplasm
cytosol
nucleus
nucleotide binding
protein binding
ATP binding
phosphotyrosine binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase activity
GenBank ID NC_000016
NM_002746
NP_002737
NT_010393
NW_926539
AC_000059
NM_001040056
NP_001035145
AC012645
AJ222708
AK091009
AY033607
AAK52329
AY033608
AAK52330
BC000205
AAH00205
BC013992
AAH13992
BX537897
CAD97888
CR595737
CR596064
CR597147
CR600245
CR603463
CR606522
CR607536
CR620058
CR621455
CR621688
CR621977
DA351318
M84490
AAA36142
X60188
CAA42744
Z11696
CAA77754
P27361
Q7Z3H5
Q8NHX0
Q8NHX1
Q9BWJ1
NC_000073
NM_011952
NP_036082
NT_039433
AC124505
X90997
AK155287
BAE33167
BC013754
AAH13754
BC029712
AAH29712
BG075319
BI414398
BQ929318
S58470
AAB19973
X64605
CAA45889
Z14249
Q63844
NC_005100
NM_017347
NP_059043
NW_001084773
XM_001079997
XP_001079997
NW_047562
AC_000069
AF155236
AAF71666
M38194
AAA41123
M61177
AAA63486
S46779
AAA11604
U12008
AAA20009
X65198
CAA46318
P21708
Q4PIY8
Source Curated
LocusLink ID 5595
26417
50689
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 601795
Alias ERK1
PRKM3
P44ERK1
P44MAPK
HS44KDAP
HUMKER1A
MGC20180
mitogen-activated protein kinase 3
extracellular signal-related kinase 1
extracellular signal-regulated kinase 1
p44
Erk-1
Esrk1
mitogen activated protein kinase 3
p44 MAP kinase
protein kinase, mitogen activated kinase 3
protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
protein kinase
mitogen activated kinase 3
extracellular-signal-regulated kinase 1
mitogen-activated 3 (MAP kinase 3; p44)
Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1)
GO ID 0005524
0004707
0000166
0005515
0004674
0016740
0007049
0006468
0000074
0008372
0016301
0001784
0004672
0004713
0009887
0016310
0006974
0007165
0005737
0005634
0007242
0000189
0045941
0007243
0005829
0005626
Swiss-Prot Accession P27361
Q7Z3H5
Q8NHX0
Q8NHX1
Q9BWJ1
Q63844
P21708
Q4PIY8
MedScan ID 5595
Unigene ID Hs.861
Mm.8385
Rn.2592
LocatorString pmquery:aquaporin