Protein : RAF1
Owner Public
URN urn:agi-llid:5894
Hugo ID 9829
Connectivity 1762
Name RAF1
Description v-raf-1 murine leukemia viral oncogene homolog 1
Notes acts as a mitogenic protein kinase; mutant forms may play a role in transformation [RGD]
RGD ID 3531
MGI ID 97847
Pathway p40 MAPK
Insulin Receptor Signaling
Antiapoptotic Pathways From IGF-1R
Jak-Stat Pathway from IL6 Receptor
Mitochondrial control of Apoptosis
Insulin pathway
EGF signaling
PDGF signaling
MAPK-ERK in Growth and Differentiation
Inhibition of Apoptosis
Erythropoietin signaling
IL-6 signaling
G-protein Coupled Receptor signaling
IL-3 signaling
IL-2 signaling
NGF signaling
Erk-PI3K in Collagen Binding
CD40L
IL-1 and IL-6 signaling
Apoptosis
Integrin Signaling
Notch -> CREB1 signaling pathway
PTPRC -> BCL6 signaling pathway
Notch -> ELK1-SRF signaling pathway
Notch -> ELK4-SRF signaling pathway
Notch -> TCF3 signaling pathway
EDG2 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
NTRKs -> TP53 signaling pathway
OPRs -> CREB1 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
OPRs -> ELK4-SRF signaling pathway
IGF1R -> MYC signaling pathway
OPRs -> STAT3 signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
PECAM1 -> SP1 signaling pathway
ENDRA -> AP-1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
ENDRA -> CREB1 signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
EPOR -> ELK1-SRF signaling pathway
PTGFR -> CREB1 signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
PTGFR -> ELK4-SRF signaling pathway
PTGFR -> MYC signaling pathway
PTGFR -> TCF3 signaling pathway
SELE -> ELK4-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
T-cell receptor -> AP-1 signaling pathway
IL4R -> ELK1-SRF signaling pathway
CD19 -> AP-1 signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
CD19 -> ELK1-SRF signaling pathway
CD19 -> ELK4-SRF signaling pathway
IL6R -> CEBPB signaling pathway
FGFRs -> RUNX2 signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
ADORA1 -> AP-1 signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
CD38 -> AP-1 signaling pathway
CD38 -> CEBPA signaling pathway
CD38 -> CREB1 signaling pathway
CD38 -> ELK1-SRF signaling pathway
CD38 -> ELK4-SRF signaling pathway
CD38 -> MYC signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
CD38 -> TCF3 signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
LEPR -> ELK1-SRF signaling pathway
ADRA1B -> STAT3 signaling pathway
LEPR -> ELK4-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
GNRHR -> ELK4-SRF signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
MPL -> SPI1 signaling pathway
HTR2A -> ELK1-SRF signaling pathway
HTR2A -> ELK4-SRF signaling pathway
AGER -> CREB1 signaling pathway
NCAM1 -> CREB1 signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
HTR2A -> GATA4 signaling pathway
NCAM1 -> MYC signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> SP1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Copy of 'Apoptosis'
Apoptosis2
tshirt 'Insulin Receptor Signaling' 1
Group Kinases
cellular physiological process
signal transduction
intracellular signaling cascade
protein kinase cascade
MAPKKK cascade
cell proliferation
regulation of progression through cell cycle
apoptosis
cytoskeleton organization and biogenesis
protein amino acid phosphorylation
heart development
response to hypoxia
intracellular
insoluble fraction
cytosol
mitochondrial outer membrane
plasma membrane
nucleotide binding
protein binding
metal ion binding
zinc ion binding
diacylglycerol binding
ATP binding
mitogen-activated protein kinase kinase binding
protein heterodimerization activity
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
MAP kinase kinase kinase activity
receptor signaling protein activity
GenBank ID NC_000003
NM_002880
NP_002871
NT_022517
NW_921651
AC_000046
AC018500
AC026170
AY271661
AAP03432
L00212
AAA60247
BC018119
AAH18119
BQ221862
CR598160
X03484
CAA27204
P04049
Q15278
NC_000072
NM_029780
NP_084056
NT_039353
NW_000264
NW_001030811
AC_000028
AC160032
X55432
AB052739
BAB39527
AB057655
BAB39748
AB057663
BAB39743
AB077145
BAB83675
AK018272
BAB31142
AK036317
AK141745
BAE24820
AK148327
AK189599
AK190457
AK191593
AK193894
AK199760
AK215463
BC015273
AAH15273
BC056439
BC092040
AAH92040
BG073005
BG085782
Q58E75
Q99N57
NC_005103
NM_012639
NP_036771
NW_001084832
NW_047696
AC_000072
BC062071
AAH62071
M15427
AAA42001
P11345
Source Curated
LocusLink ID 5894
110157
24703
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 164760
Alias CRAF
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1
Oncogene RAF1
raf proto-oncogene serine/threonine protein kinase
Craf1
v-Raf
AA990557
BB129353
MGC102375
6430402F14Rik
D830050J10Rik
protein kinase raf 1
sarcoma 3611 oncogene
Craf1 transforming gene
murine sarcoma 3611 oncogene 1
v-raf-1 leukemia viral oncogene 1
murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
GO ID 0005524
0019992
0046872
0000166
0005515
0004674
0005057
0016740
0008270
0006915
0008283
0007242
0006468
0005741
0016301
0004672
0050875
0007010
0007243
0000074
0007165
0005829
0005622
0005886
0004709
0031434
0046982
0000165
0007507
0001666
0005626
Swiss-Prot Accession P04049
Q15278
Q58E75
Q99N57
P11345
Unigene ID Hs.159130
Mm.184163
Rn.33262