Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:6714:out-urn:agi-enz:3.4.22.17::positive
Entities SRC --+> calpain
References 5
Connectivity 2
MedLine Reference 15068671:2
Sentence Our results demonstrate that calpain activity is enhanced upon transformation induced by the v-Src, v-Jun, v-Myc, k-Ras, and v-Fos oncoproteins.
MedLine Reference 11739739:10050
Sentence In this study we investigated the mechanism by which v-Src may promote calpain activity during cell transformation and how elevated calpain activity contributes to transformation.
Journal Mol. Cell. Biol
Journal Reference v22 i1 p257
Journal Link http://mcb.asm.org/cgi/content/full/22/1/257
Organism Mus musculus
MedLine Reference 12421874:1176
Sentence The tyrosine kinase Src activates calpain proteases that digest FAK during transformation and invasion (70 ,95 ,96 ).
Journal Nutrition
Journal Reference v132 i11 p3482S (1996)
Journal Link http://www.nutrition.org/cgi/content/full/132/11/3482S
Organism plant
Source Curated
MedLine Reference 11739738:1050
Sentence In this study we investigated the mechanism by which v-Src may promote calpain activity during cell transformation and how elevated calpain activity contributes to transformation.
Journal Mol. Cell. Biol
Journal Reference v22 i1 p257 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/1/257
Organism drosophila
Source Curated
MedLine Reference 3932485295
Sentence Calpain activation by v-src is believed to promote focal adhesion disruption, loss of substrate adhesion and migration of v-src??????transformed cells ( Carragher et al., 2002 ).
Journal J. Cell Biol
Journal Reference v158 i3 p519 (2002)
Journal Link http://www.jcb.org/cgi/content/full/158/3/519
Source Curated