Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:5747:out-urn:agi-enz:3.4.22.17::positive
Entities PTK2 --+> calpain
References 3
Connectivity 2
MedLine Reference 12932330:8
Sentence Furthermore, FAK is necessary for recruiting both Calpain 2 and p42ERK/MAPK to peripheral adhesion sites facilitating maximal Calpain activity.
MedLine Reference 15340073:10039
Sentence In this regard, we have also shown that FAK can act as an adaptor protein that permits the assembly of a complex consisting of calpain 2 and its upstream activator p42ERK, promoting calpain activity at the membrane ( 17 ).
Journal Mol. Cell. Biol
Journal Reference v24 i18 p8113
Journal Link http://mcb.asm.org/cgi/content/full/24/18/8113
MedLine Reference 16159962:10233
Sentence Nevertheless, this does not mean that cleavage of FAK is not implicated in FA disassembly, since cleavage of FAK is associated with increased Src activity, leading to phosphorylation of FAK and activation of calpain (Fincham and Frame, 1998 ; McLean et al., 2000 ; Carragher et al., 2001 ).
Journal Cell Sci
Journal Reference v118 i19 p4415
Journal Link http://jcs.biologists.org/cgi/content/full/118/19/4415