Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-enz:3.4.22.17:out-urn:agi-llid:6714::positive
Entities calpain --+> SRC
References 8
Connectivity 2
MedLine Reference 15753384:10198
Sentence ErbB2 stabilizes Src by inhibiting calpain-mediated Src degradation.
Journal Cancer Res
Journal Reference v65 i5 p1858
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/65/5/1858
Organism Mus musculus
MedLine Reference 8999848:10084
Sentence Inhibition of calpain-catalyzed cleavage of pp60 c- src by calpeptin had no effect on platelet aggregation induced by ionophore A23187 (Fig. 1 ) or thrombin (data not shown).
Journal J. Biol. Chem
Journal Reference v272 i3 p1694
Journal Link http://www.jbc.org/cgi/content/full/272/3/1694
MedLine Reference 15131115:10275
Sentence An alternative mechanism relates to calpain-mediated cleavage of various signaling enzymes (FAK, Src, and PTP-1B) and cytoskeletal proteins (talin, filamin-1, and cortactin) ( 33 ? 37 ).
Journal J. Biol. Chem
Journal Reference v279 i29 p30697
Journal Link http://www.jbc.org/cgi/content/full/279/29/30697
Organism Mus musculus
MedLine Reference 15340073:10193
Journal Mol. Cell. Biol
Journal Reference v24 i18 p8113
Journal Link http://mcb.asm.org/cgi/content/full/24/18/8113
MedLine Reference 11739739:10196
Journal Mol. Cell. Biol
Journal Reference v22 i1 p257
Journal Link http://mcb.asm.org/cgi/content/full/22/1/257
Organism Mus musculus
MedLine Reference 11739738:1128
Sentence It has previously been demonstrated that FAK cleavage induced in response to v-Src activation is mediated by calpain activity ( 12 ).
Journal Mol. Cell. Biol
Journal Reference v22 i1 p257 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/1/257
Organism drosophila
Source Curated
MedLine Reference 9312088:1171
Sentence However, pretreating purified calpain with 100 ???µg/ml calpeptin completely blocked calpain autolysis and abolished both pp60 c- src and PTP-1B cleavage.
Journal J. Biol. Chem
Journal Reference v272 i40 p24876 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/24876
Source Curated
MedLine Reference 8999848:1084
Sentence Inhibition of calpain-catalyzed cleavage of pp60 c- src by calpeptin had no effect on platelet aggregation induced by ionophore A23187 (Fig. 1 ) or thrombin (data not shown).
Journal J. Biol. Chem
Journal Reference v272 i3 p1694 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/3/1694
Source Curated
CellType platelet