Protein : GSK3B


Owner	Public
URN	urn:agi-llid:2932
Hugo ID	4617
Connectivity	1087
Name	GSK3B
Description	glycogen synthase kinase 3 beta
Notes	mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD]


RGD ID	70982


MGI ID	1861437


Pathway	Wnt signaling
	Insulin Receptor Signaling
	NTRK1 -> MYCN signaling pathway
	IL12R -> NFATC1 signaling pathway
	RET -> HSF1 signaling pathway
	IL15R -> NFATC2 signaling pathway
	Frizzled -> CTNNB1 signaling pathway
	INSR -> CTNNB1 signaling pathway
	INSR -> SREBF1 signaling pathway
	CD28 -> NFAT5 signaling pathway
	ITGAM/ITGB2 -> CEBPB signaling pathway
	CD28 -> NFATC1 signaling pathway
	CD28 -> NFATC2 signaling pathway
	CD28 -> NFATC3 signaling pathway
	CD28 -> NFATC4 signaling pathway
	ITGB1 -> CTNNB1 signaling pathway
	KDR -> CTNNB1 signaling pathway
	ICAM2 -> CTNNB1 signaling pathway
	TNFRSF5/13B -> NFATC1 signaling pathway
	tshirt 'Insulin Receptor Signaling' 2


Group	Kinases
	Wnt receptor signaling pathway
	fat cell differentiation
	cell proliferation
	re-entry into mitotic cell cycle
	anti-apoptosis
	induction of apoptosis
	establishment and-or maintenance of cell polarity
	establishment of cell polarity
	protein export from nucleus
	glycogen metabolism
	protein amino acid phosphorylation
	negative regulation of transcription, DNA-dependent
	organ morphogenesis
	response to stress
	cytoplasm
	cytosol
	nucleus
	nucleotide binding
	protein binding
	ATP binding
	beta-catenin binding
	NF-kappaB binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	tau-protein kinase activity
	glycogen synthase kinase 3 activity


Source	Curated


OMIM ID	605004


Alias	glycogen synthase kinase 3 beta
	GSK3
	GSK-3
	C86142
	GSK-3beta
	7330414F15Rik
	8430431H08Rik