Protein : MAP2K1


Owner	Public
URN	urn:agi-llid:5604
Hugo ID	6840
Connectivity	1248
Name	MAP2K1
Description	mitogen activated protein kinase kinase 1
Notes	kinase that activates Mapk3 (Erk1) and Mapk1 (Erk2) kinases [RGD]


RGD ID	70495


MGI ID	1346866


Pathway	Jnk-mapk
	p40 MAPK
	Insulin Receptor Signaling
	Antiapoptotic Pathways From IGF-1R
	MAPK-ERK in Growth and Differentiation
	G-protein Coupled Receptor signaling
	Integrin Signaling
	AGTR1 -> ELK1-SRF signaling pathway
	Notch -> CREB1 signaling pathway
	PTPRC -> BCL6 signaling pathway
	Notch -> ELK1-SRF signaling pathway
	AGTR1 -> ELK4-SRF signaling pathway
	Notch -> ELK4-SRF signaling pathway
	Notch -> TCF3 signaling pathway
	EDG2 -> ELK4-SRF signaling pathway
	EDG3/5 -> AP-1 signaling pathway
	AGTR1 -> TP53 signaling pathway
	TNFRSF6 -> HSF1 signaling pathway
	AGTR2 -> CREB1 signaling pathway
	EDG3/5 -> ELK1-SRF signaling pathway
	VIPR1 -> CEBPB signaling pathway
	EDG3/5 -> ELK4-SRF signaling pathway
	EGFR -> AP-1 signaling pathway
	AGTR2 -> ELK1-SRF signaling pathway
	AGTR2 -> ELK4-SRF signaling pathway
	NTRKs -> AP-1 signaling pathway
	NTRKs -> CREB1 signaling pathway
	VIPR1 -> CEBPD signaling pathway
	NTRKs -> ELK1-SRF signaling pathway
	NTRKs -> ELK4-SRF signaling pathway
	AGTR2 -> TP53 signaling pathway
	ERBB2 -> ETV4 signaling pathway
	EGFR -> ATF2 signaling pathway
	EGFR -> SMAD1 signaling pathway
	NTRKs -> MYC signaling pathway
	NTRKs -> STAT5A signaling pathway
	VIPR1 -> CREB1 signaling pathway
	NTRKs -> TP53 signaling pathway
	OPRs -> CREB1 signaling pathway
	IGF1R -> ELK1-SRF signaling pathway
	B-cell receptor -> AP-1 signaling pathway
	EGFR/ERBB2 -> HIF1A signaling pathway
	ERBB2/3 -> SP1 signaling pathway
	IGF1R -> ELK4-SRF signaling pathway
	OPRs -> ELK1-SRF signaling pathway
	IGF1R -> HIF1A signaling pathway
	OPRs -> ELK4-SRF signaling pathway
	IGF1R -> MYC signaling pathway
	OPRs -> STAT3 signaling pathway
	IGF1R -> SREBF1 signaling pathway
	EGFR/ERBB2 -> TP53 signaling pathway
	F2R -> AP-1 signaling pathway
	PECAM1 -> SP1 signaling pathway
	ENDRA -> AP-1 signaling pathway
	PLAUR -> ELK1-SRF signaling pathway
	RET -> HSF1 signaling pathway
	PLAUR -> ELK4-SRF signaling pathway
	ENDRA -> CREB1 signaling pathway
	ENDRB -> AP-1 signaling pathway
	F2R -> CREB1 signaling pathway
	ENDRB -> CREB1 signaling pathway
	ENDRB -> ELK1-SRF signaling pathway
	F2R -> ELK1-SRF signaling pathway
	ENDRB -> ELK4-SRF signaling pathway
	F2R -> ELK4-SRF signaling pathway
	PTAFR -> AP-1 signaling pathway
	F2R -> SP1 signaling pathway
	PTAFR -> ATF1 signaling pathway
	PTAFR -> CREB1 signaling pathway
	PTAFR -> ELK1-SRF signaling pathway
	PTAFR -> ELK4-SRF signaling pathway
	EPOR -> ELK1-SRF signaling pathway
	PTGFR -> CREB1 signaling pathway
	EPOR -> ELK4-SRF signaling pathway
	SELE -> ELK1-SRF signaling pathway
	IL1R -> NF-kB signaling pathway
	EPOR -> FOS signaling pathway
	PTGFR -> ELK1-SRF signaling pathway
	FCGR3A -> ELK1-SRF signaling pathway
	PTGFR -> ELK4-SRF signaling pathway
	PTGFR -> MYC signaling pathway
	CCKAR -> ELK1-SRF signaling pathway
	PTGFR -> TCF3 signaling pathway
	SELE -> ELK4-SRF signaling pathway
	CCKAR -> ELK4-SRF signaling pathway
	PTGIR -> ATF1 signaling pathway
	CCKBR -> ELK1-SRF signaling pathway
	FCGR3A -> ELK4-SRF signaling pathway
	CCKBR -> ELK4-SRF signaling pathway
	ERBB2 -> EP300 signaling pathway
	ERBB2 -> ETS1 signaling pathway
	PTGIR -> CREB1 signaling pathway
	PTGIR -> ELK1-SRF signaling pathway
	ERBB2 -> ETS2 signaling pathway
	PTGIR -> ELK4-SRF signaling pathway
	PTGIR -> MYC signaling pathway
	ERBB2 -> ETV1 signaling pathway
	IL2R -> ELK1-SRF signaling pathway
	IL2R -> ELK4-SRF signaling pathway
	IL2R -> MYC signaling pathway
	T-cell receptor -> AP-1 signaling pathway
	IL4R -> ELK1-SRF signaling pathway
	CD19 -> AP-1 signaling pathway
	IL4R -> ELK4-SRF signaling pathway
	IL4R -> HMGY signaling pathway
	CD19 -> ELK1-SRF signaling pathway
	CD19 -> ELK4-SRF signaling pathway
	TACR1 -> ELK1-SRF signaling pathway
	IL6R -> CEBPB signaling pathway
	FGFRs -> RUNX2 signaling pathway
	IL6R -> ELK1-SRF signaling pathway
	IL6R -> ELK4-SRF signaling pathway
	CD22/72 -> AP-1 signaling pathway
	TACR1 -> ELK4-SRF signaling pathway
	TBXA2R -> CREB1 signaling pathway
	INSR -> ELK1-SRF signaling pathway
	INSR -> ELK4-SRF signaling pathway
	ADORA1 -> AP-1 signaling pathway
	INSR -> SREBF1 signaling pathway
	INSR -> SREBF2 signaling pathway
	FSHR -> CREB1 signaling pathway
	FSHR -> ELK1-SRF signaling pathway
	FSHR -> ELK4-SRF signaling pathway
	ITGB1 -> AP-1 signaling pathway
	FSHR -> GATA4 signaling pathway
	CD38 -> AP-1 signaling pathway
	GCGR -> CREB1 signaling pathway
	ITGB1 -> ELK1-SRF signaling pathway
	CD38 -> CEBPA signaling pathway
	ITGB1 -> ELK4-SRF signaling pathway
	CD38 -> CREB1 signaling pathway
	CD38 -> ELK1-SRF signaling pathway
	CD38 -> ELK4-SRF signaling pathway
	ITGB1 -> SREBF1 signaling pathway
	GCGR -> ELK1-SRF signaling pathway
	CD38 -> MYC signaling pathway
	GCGR -> ELK4-SRF signaling pathway
	ITGB1 -> SREBF2 signaling pathway
	GCGR -> SP1 signaling pathway
	KDR -> ATF1 signaling pathway
	GFRs -> AP-1 signaling pathway
	GFRs -> CREB1 signaling pathway
	GFRs -> CREBBP signaling pathway
	CD38 -> TCF3 signaling pathway
	GFRs -> ELK1-SRF signaling pathway
	ADRA1B -> ELK1-SRF signaling pathway
	KDR -> ATF2 signaling pathway
	GFRs -> ELK4-SRF signaling pathway
	KDR -> CREB1 signaling pathway
	CHRM1 -> CREB1 signaling pathway
	GFRs -> MYC signaling pathway
	GFRs -> NCOR2 signaling pathway
	KDR -> ELK1-SRF signaling pathway
	KDR -> ELK4-SRF signaling pathway
	KIT -> MITF signaling pathway
	GHR -> ELK1-SRF signaling pathway
	CHRM1 -> ELK1-SRF signaling pathway
	CHRM1 -> ELK4-SRF signaling pathway
	CHRNA7 -> CREB1 signaling pathway
	ADRA1B -> ELK4-SRF signaling pathway
	GHR -> ELK4-SRF signaling pathway
	GHR -> MYC signaling pathway
	LEPR -> ELK1-SRF signaling pathway
	ADRA1B -> STAT3 signaling pathway
	CNRs -> CREB1 signaling pathway
	TNFRs -> AP-1 signaling pathway
	LEPR -> ELK4-SRF signaling pathway
	CNRs -> ELK1-SRF signaling pathway
	CNRs -> ELK4-SRF signaling pathway
	ADRB1 -> STAT3 signaling pathway
	GNRHR -> ELK1-SRF signaling pathway
	GNRHR -> ELK4-SRF signaling pathway
	GRIN1 -> CREB1 signaling pathway
	ADRB2 -> CREB1 signaling pathway
	GRM1/5 -> CREB1 signaling pathway
	MPL -> CREB1 signaling pathway
	ADRB2 -> STAT3 signaling pathway
	MPL -> SP1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	HTR2A -> ELK1-SRF signaling pathway
	TNFRs -> CREB1 signaling pathway
	ADRB3 -> STAT3 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	HTR2A -> ELK4-SRF signaling pathway
	AGER -> CREB1 signaling pathway
	NCAM1 -> CREB1 signaling pathway
	NCAM1 -> ELK1-SRF signaling pathway
	NCAM1 -> ELK4-SRF signaling pathway
	DRD1 -> CREB1 signaling pathway
	HTR2A -> GATA4 signaling pathway
	NCAM1 -> MYC signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRs -> TP53 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	ICAM1 -> CREB1 signaling pathway
	DRD1 -> ELK1-SRF signaling pathway
	DRD1 -> ELK4-SRF signaling pathway
	TNFRSF1A -> ATF2 signaling pathway
	DRD2 -> AP-1 signaling pathway
	TNFRSF1A -> CREB1 signaling pathway
	ICAM1 -> ELK1-SRF signaling pathway
	NGFR -> CEBPB signaling pathway
	TNFRSF1A -> ELK1-SRF signaling pathway
	NGFR -> CREB1 signaling pathway
	ICAM1 -> ELK4-SRF signaling pathway
	NGFR -> ELK1-SRF signaling pathway
	TNFRSF1A -> ELK4-SRF signaling pathway
	NGFR -> ELK4-SRF signaling pathway
	ICAM1 -> MYC signaling pathway
	DRD2 -> CREB1 signaling pathway
	NGFR -> TP53 signaling pathway
	DRD2 -> ELK1-SRF signaling pathway
	AGER -> SP1 signaling pathway
	AGTR1 -> CREB1 signaling pathway
	TNFRSF1A -> TP53 signaling pathway
	DRD2 -> ELK4-SRF signaling pathway
	EDARs -> AP-1 signaling pathway
	EDG2 -> ELK1-SRF signaling pathway
	tshirt 'Insulin Receptor Signaling' 1


Group	Kinases
	signal transduction
	protein kinase cascade
	neuron differentiation
	keratinocyte differentiation
	cell motility
	protein amino acid phosphorylation
	chemotaxis
	cytosol
	nucleotide binding
	protein binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	MAP kinase kinase activity


GenBank ID	NC_000015
	NM_002755
	NP_002746
	NT_010194
	NW_925884
	AC_000058
	AC011276
	AC055855
	AC116913
	CR621481
	L05624
	AAA36318
	L11284
	Q02750
	NC_000075
	NM_008927
	NP_032953
	NT_039474
	NW_000353
	NW_001030907
	AC_000031
	AC160118
	AY902345
	AAY21055
	AB041567
	BAA95051
	AK146233
	BAE26999
	AK146931
	BAE27542
	AK154793
	BAE32832
	AK165664
	BAE38326
	AK165894
	BAE38443
	AK167336
	BAE39437
	AK192193
	AK192210
	AK193946
	AK194551
	AK196845
	AK197193
	AK199082
	AK199200
	AK199288
	AK203853
	AK214848
	AU041108
	BC051137
	AAH51137
	BC054754
	AAH54754
	L02526
	AAA39523
	P31938
	NC_005107
	NM_031643
	NP_113831
	NW_001084873
	NW_047799
	AC_000076
	BC089772
	AAH89772
	D13341
	BAA02603
	D14591
	BAA03441
	X62313
	CAA44192
	Z16415
	CAA78905
	Q01986
	Q5EBD5


Source	Curated


LocusLink ID	5604
	26395
	170851


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	176872


Alias	MEK1
	MKK1
	MAPKK1
	PRKMK1
	mitogen-activated protein kinase kinase 1
	protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
	MEKK1
	mitogen activated protein kinase kinase 1
	MAP kinase kinase 1
	protein kinase, mitogen activated, kinase 1, p45
	MAP kinase/Erk kinase 1


GO ID	0005524
	0004708
	0000166
	0005515
	0004674
	0004713
	0016740
	0006928
	0006935
	0006468
	0007165
	0016301
	0004672
	0030216
	0030182
	0007243
	0005829


Swiss-Prot Accession	Q02750
	P31938
	Q01986
	Q5EBD5


Unigene ID	Hs.145442
	Mm.248907
	Mm.426740
	Rn.5850