Protein : GRB10
Owner Public
URN urn:agi-llid:2887
Hugo ID 4564
Connectivity 179
Name GRB10
Description similar to Grb10 protein (predicted)
Notes The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
RGD ID 1566234
MGI ID 103232
Pathway Insulin Receptor Signaling
EPHB1
tshirt 'Insulin Receptor Signaling' 1
Group Ph
Sh2
cell-cell signaling
signal transduction
intracellular signaling cascade
insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
cytoplasm
cytosol
plasma membrane
protein binding
SH3-SH2 adaptor activity
receptor activity
GenBank ID NC_000007
NM_001001555
NP_001001555
NM_001001549
NP_001001549
NM_005311
NP_005302
NM_001001550
NP_001001550
NT_033968
NT_079592
NW_923273
AC_000050
AC_000068
AC004920
AC005153
AAS00377
AC007089
AC080092
AAS07426
AF073363
AAC83655
AF073364
AF073365
AF073366
AF073367
AF073368
AF073369
AF073370
AF073371
AF073372
AF073373
AF073374
AF073375
AF073376
AF073377
AF073378
AAC83654
CH236955
AF000017
AAC19748
AF000018
AAC19749
AF001534
AAB81134
AJ271366
CAB96542
AK021643
BC024285
AAH24285
BQ006601
BU598359
BX649028
CR624299
D86962
BAA13198
U34355
AAA88819
U66065
AAC50671
U69276
AAB08431
O00428
Q13322
Q75M93
Q75MT1
NC_000077
NM_010345
NP_034475
NT_039515
NW_000035
NW_001030444
AC_000033
AL645803
CAI23990
AL663087
CAI25683
CAI25684
CAI25687
U18996
AAB53687
AB106541
BAC66117
AF022072
AAB72103
AK012646
AK017862
AK030727
BAC27100
AK032927
BAC28088
AK079122
AK080969
AK160651
AK163841
BAE37514
AK169000
BAE40799
BC016111
AAH16111
BC033917
BC053842
AAH53842
BG065213
Q5SSH3
Q5SSH4
Q60760
NC_005113
XM_573664
XP_573664
NW_001084694
XM_001053718
XP_001053718
NW_047430
AC_000082
Source Curated
LocusLink ID 2887
14783
498416
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 601523
Alias RSS
IRBP
MEG1
GRB-IR
KIAA0207
growth factor receptor-bound protein 10
GRB10 adaptor protein
maternally expressed gene 1
AI325020
mKIAA0207
5730571D09Rik
RP23-119N24.1
growth factor receptor bound protein 10
similar to Grb10 protein (predicted)
GO ID 0005070
0005515
0007267
0008286
0007242
0005737
0005886
0004872
0048009
0007165
0005829
Swiss-Prot Accession O00428
Q13322
Q75M93
Q75MT1
Q5SSH3
Q5SSH4
Q60760
Unigene ID Hs.164060
Mm.273117