ProtModification :

Mechanism dephosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-complex:3000121:out-urn:agi-llid:2998::unknown
Entities protein phosphatase 1 ---> GYS2
References 3
Connectivity 2
Effect unknown
MedLine Reference 2985384:9
Sentence However, dephosphorylation of glycogen synthase and pyruvate kinase by phosphatase-1 was stimulated by this mucopolysaccharide.
Organism rat
Source Curated
MedLine Reference 11238900:1429
Sentence Insulin-induced activation of PP1 dephosphorylates glycogen synthase, resulting in the activation of glycogen synthase ( 5 , 6 ).
Journal Mol. Cell. Biol
Journal Reference v21 i5 p1633 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/5/1633
Organism mouse
Source Curated
MedLine Reference 10346822:1023
Sentence Whereas it has been well established that glycogen synthase is dephosphorylated (activated) by protein phosphatase 1 (PP1) ( 7 ) and phosphorylated (inactivated) by glycogen synthase kinase 3 (GSK3) ( 36 ), the precise molecular mechanism by which insulin regulates this complex process is not well understood.
Journal Genes & Dev
Journal Reference v13 i10 p1342 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/10/1342
Organism drosophila
Source Curated