ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:2932:out-urn:agi-llid:2998::negative
Entities GSK3B ---| GYS2
References 55
Connectivity 2
Effect negative
MedLine Reference 12086949:1035
Sentence GSK-3 phosphorylates GS on three specific residues.
Journal Diabetes
Journal Reference v51 i7 p2190 (2002)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/7/2190
Tissue endothelial
Source Curated
MedLine Reference 11272135:1029
Sentence In vitro GSk3 phosphorylates two of the four sites on glycogen synthase (GS), which also become dephosphorylated in response to insulin ( 7 ).
Journal Diabetes
Journal Reference v50 i2 p265 (2001)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/2/265
Tissue skeletal muscle
Source Curated
MedLine Reference 12538764:1021
Sentence Results Discussion References GSK-3 was identified over 20 years ago as a kinase that phosphorylates glycogen synthase (for a review, see Frame and Cohen, 2001 ; Embi et al., 1980 ).
Journal Cell Sci
Journal Reference v116 i4 p637 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/116/4/637
Source Curated
MedLine Reference 12606497:1033
Sentence There is convincing evidence that GSK-3 inactivation and GS activation are causally related, as GSK-3 phosphorylates GS at inactivating sites in vitro and overexpression of active forms of GSK-3 in cells suppresses GS function ( 11 , 12 ).
Journal Diabetes
Journal Reference v52 i3 p588 (2003)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/52/3/588
Organism mouse
Tissue blood
Source Curated
MedLine Reference 11872655:1018
Sentence Part of the action of insulin in this pathway in liver stems from the ability of insulin to activate the glycogen synthase phosphatase, which dephosphorylates sites on glycogen synthase that are phosphorylated by glycogen synthase kinase-3 (GSK3).
Journal Diabetes
Journal Reference v51 i3 p591 (2002)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/3/591
Organism mouse
Organ Liver Stem
Source Curated
MedLine Reference 11723053:1261
Journal Diabetes
Journal Reference v50 i12 p2709 (2001)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/12/2709
Organism rat
Organ heart
Source Curated
MedLine Reference 11223174:4
Organism rat
Source Curated
CellType hepatocyte
MedLine Reference 10909964:4
CellLineName Rat1
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 9603900:1043
Journal J. Biol. Chem
Journal Reference v273 i23 p14063 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/23/14063
CellLineName 3T3 L1
Organism mouse
Source Curated
MedLine Reference 9478990:1152
Journal J. Biol. Chem
Journal Reference v273 i9 p5315 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/9/5315
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 9065430:1192
Journal J. Biol. Chem
Journal Reference v272 i12 p7713 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/12/7713
Organism rat
Tissue fat
Source Curated
MedLine Reference 12764143:1038
Journal J. Biol. Chem
Journal Reference v278 i33 p31277 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/33/31277
Source Curated
MedLine Reference 10455163:1034
Journal J. Biol. Chem
Journal Reference v274 i35 p24896 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/35/24896
Organism rat
Source Curated
MedLine Reference 10346822:1023
Journal Genes & Dev
Journal Reference v13 i10 p1342 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/10/1342
Organism drosophila
Source Curated
MedLine Reference 11334436:1032
Journal Diabetes
Journal Reference v50 i5 p937 (2001)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/5/937
Organism rat
Tissue muscle
Organ liver
Source Curated
MedLine Reference 12525490:1081
Journal J. Biol. Chem
Journal Reference v278 i12 p10297 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/12/10297
CellLineName C2C12
Organism mouse
Source Curated
CellType myotube
MedLine Reference 9712712:2
Organism frog
Source Curated
MedLine Reference 2850771:1
Source Curated
MedLine Reference 11245670:1022
Journal J. Neurosci
Journal Reference v21 i6 p1857 (2001)
Journal Link http://www.jneurosci.org/cgi/content/full/21/6/1857
Source Curated
CellType neural
MedLine Reference 9582355:1033
Journal J. Biol. Chem
Journal Reference v273 i21 p13150 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/21/13150
Source Curated
MedLine Reference 9312151:1028
Journal J. Biol. Chem
Journal Reference v272 i40 p25326 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/25326
Source Curated
CellType neural
MedLine Reference 14561750:1026
Journal J. Biol. Chem
Journal Reference v278 i52 p52432 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/52/52432
Source Curated
MedLine Reference 12551948:1276
Journal J. Biol. Chem
Journal Reference v278 i15 p12722 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/15/12722
Organism bovine
Organ brain
Source Curated
MedLine Reference 12095990:1048
Journal J. Biol. Chem
Journal Reference v277 i36 p32915 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/36/32915
Organism plant
Tissue muscle
Source Curated
MedLine Reference 10748179:1150
Journal J. Biol. Chem
Journal Reference v275 i21 p15765 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/21/15765
CellLineName 3T3 L1
Organism mouse
Source Curated
MedLine Reference 11967263:1024
Journal J. Biol. Chem
Journal Reference v277 i26 p23330 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/26/23330
Source Curated
MedLine Reference 11812770:1322
Journal J. Biol. Chem
Journal Reference v277 i14 p11933 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/14/11933
Organism bovine
Organ brain
Source Curated
MedLine Reference 11533051:1038
Journal J. Biol. Chem
Journal Reference v276 i44 p40910 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/44/40910
Organism rat
Source Curated
MedLine Reference 10753899:1229
Journal J. Biol. Chem
Journal Reference v275 i15 p10983 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/15/10983
Organism plant
Source Curated
MedLine Reference 11289034:1212
Journal Diabetes
Journal Reference v50 i4 p720 (2001)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/4/720
Source Curated
CellType myoblast
MedLine Reference 9003374:7
Tissue muscle
Source Curated
MedLine Reference 12805359:1188
Journal J. Biol. Chem
Journal Reference v278 i33 p30835 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/33/30835
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 12502489:1035
Journal Diabetes
Journal Reference v52 i1 p21 (2003)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/52/1/21
Organism mouse
Organ liver
Source Curated
MedLine Reference 11959983:1117
Journal PNAS
Journal Reference v99 i8 p5313 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/8/5313
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 10954733:1133
Journal PNAS
Journal Reference v97 i18 p10236 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/18/10236
Organism mouse
Tissue muscle
Organ liver
Source Curated
MedLine Reference 11283248:1048
Journal Mol. Cell. Biol
Journal Reference v21 i8 p2683 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/8/2683
Organism mouse
Tissue skeletal muscle
Source Curated
MedLine Reference 15671078:5
Organism rat
Tissue muscle
Source Curated
MedLine Reference 8816781:9
CellLineName 293
Source Curated
MedLine Reference 8226927:10
Source Curated
MedLine Reference 12626660:1125
Journal JPET
Journal Reference v305 i3 p974 (2003)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/305/3/974
Organism mouse
Source Curated
MedLine Reference 9873015:1024
Journal J. Biol. Chem
Journal Reference v274 i2 p776 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/2/776
Tissue blood
Source Curated
MedLine Reference 12890675:1033
Journal J. Biol. Chem
Journal Reference v278 i41 p39422 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/41/39422
Organism mouse
Organ heart
Source Curated
MedLine Reference 11289110:1152
Journal Cancer Res
Journal Reference v61 i6 p2429 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/6/2429
CellLineName HT 1080
Organism dog
Source Curated
MedLine Reference 14769918:1147
Journal PNAS
Journal Reference v101 i7 p2082 (1996)
Journal Link http://www.pnas.org/cgi/content/full/101/7/2082
Organism mouse
Organ liver
Source Curated
MedLine Reference 14701753:1148
Journal Mol. Cell. Biol
Journal Reference v24 i2 p823 (2004)
Journal Link http://mcb.asm.org/cgi/content/full/24/2/823
Source Curated
MedLine Reference 11238900:1427
Journal Mol. Cell. Biol
Journal Reference v21 i5 p1633 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/5/1633
Organism mouse
Source Curated
MedLine Reference 10373548:1372
Journal Mol. Cell. Biol
Journal Reference v19 i7 p4989 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/7/4989
Tissue skeletal muscle
Source Curated
CellType myotube
MedLine Reference 11427888:0
Source Curated
MedLine Reference 12093801:1046
Journal J. Biol. Chem
Journal Reference v277 i37 p33690 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/33690
Organism mouse
Source Curated
MedLine Reference 11473107:1174
Journal J. Biol. Chem
Journal Reference v276 i39 p36734 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/39/36734
CellLineName Neuro 2A
Organism frog
Source Curated
MedLine Reference 11087733:1020
Journal J. Biol. Chem
Journal Reference v276 i7 p5339 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/7/5339
Organism plant
Source Curated
MedLine Reference 10364240:1207
Journal J. Biol. Chem
Journal Reference v274 i25 p17934 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/25/17934
Organism mouse
Source Curated
MedLine Reference 12783867:1208
Journal J. Biol. Chem
Journal Reference v278 i41 p39311 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/41/39311
Organism mouse
Source Curated
MedLine Reference 12823547:1157
Journal Eur. J. Biochem
Journal Reference v270 i13 p2773.html) (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/270/13/2773.h
Organism rat
Source Curated
CellType adipocyte
MedLine Reference 12765949:1213
Journal Diabetes
Journal Reference v52 i6 p1393 (2003)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/52/6/1393
Source Curated