ProtModification :

Mechanism dephosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:2932:out-urn:agi-complex:3000040::negative
Entities GSK3B ---| Translation initiation factor eIF-2B
References 21
Connectivity 2
Effect negative
MedLine Reference 11238380:1042
Sentence GSK-3 phosphorylates a single site in eIF2B (Ser540 in its epsilon-subunit), leading to inactivation of eIF2B ( 82 ).
Journal Genes & Dev
Journal Reference v15 i5 p603 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/5/603
CellLineName CHO
Source Curated
MedLine Reference 8626696:1019
Sentence Since phosphorylation of eIF2B by GSK-3 appears to inhibit nucleotide exchange in vitro , this provides a potential mechanism by which eIF2B may be activated.
Journal J. Biol. Chem
Journal Reference v271 i19 p11410 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/19/11410
Source Curated
CellType t cell
MedLine Reference 9685326:1019
Sentence In addition to glycogen synthase, GSK-3 phosphorylates a broad range of substrates, including several transcription factors and translation initiation factor eIF2B ( 16 ).
Journal J. Biol. Chem
Journal Reference v273 i32 p19929 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/32/19929
Organism rat
Tissue hematological
Source Curated
CellType neural
MedLine Reference 12356745:1200
Sentence It is interesting that phosphorylation of mammalian eIF2B by GSK-3 in this region (the rat sequence is underlined in Figure 3 ) can reduce mammalian eIF2B activity in a similar way to the yeast mutations at T552 and S576.
Journal EMBO
Journal Reference v21 i19 p5292 (2002)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/21/19/5292
Organism yeast
Source Curated
MedLine Reference 9458731:1229
Sentence It is noteworthy that glycogen synthase kinase-3 (GSK-3) phosphorylates eIF-2B ( 42 ) and that the activity of GSK-3 may be regulated by insulin in L6 myoblasts through the MAP kinase pathway ( 6 ).
Journal Cell Phys
Journal Reference v274 i1 pC221 (1998)
Journal Link http://ajpcell.physiology.org/cgi/content/full/274/1/C221
CellLineName L6
Source Curated
CellType myoblast
MedLine Reference 8663242:1196
Journal J. Biol. Chem
Journal Reference v271 i27 p16047 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/27/16047
Organism rat
Tissue smooth muscle
Organ aorta
Source Curated
MedLine Reference 11060303:1059
Journal J. Biol. Chem
Journal Reference v276 i6 p3733 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/6/3733
Organism drosophila
Organ brain
Source Curated
MedLine Reference 11707417:1232
Journal EMBO
Journal Reference v20 i22 p6464 (2001)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/20/22/6464
Organism yeast
Source Curated
MedLine Reference 11533294:1082
Journal Nutrition
Journal Reference v131 i9 p2460S (2001)
Journal Link http://www.nutrition.org/cgi/content/full/131/9/2460S
CellLineName CHO.T
Source Curated
MedLine Reference 11909969:1037
Journal Mol. Cell. Biol
Journal Reference v22 i8 p2799 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/8/2799
Organism mouse
Source Curated
MedLine Reference 11884597:1042
Journal Mol. Cell. Biol
Journal Reference v22 i7 p2099 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/7/2099
Organism mouse
Source Curated
MedLine Reference 10373548:1385
Journal Mol. Cell. Biol
Journal Reference v19 i7 p4989 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/7/4989
Organ kidney
Source Curated
MedLine Reference 9237674:4
Source Curated
MedLine Reference 11756553:9
CellLineName PC 12
Organism rat
Source Curated
MedLine Reference 9468292:1
Source Curated
MedLine Reference 11087733:1020
Journal J. Biol. Chem
Journal Reference v276 i7 p5339 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/7/5339
Organism plant
Source Curated
MedLine Reference 10764740:1129
Journal J. Biol. Chem
Journal Reference v275 i25 p19192 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/25/19192
Organism rat
Source Curated
CellType neural
MedLine Reference 9488678:1041
Journal J. Biol. Chem
Journal Reference v273 i10 p5536 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/10/5536
Organism rat
Source Curated
MedLine Reference 11782539:1174
Journal PNAS
Journal Reference v99 i2 p907 (2002)
Journal Link http://www.pnas.org/cgi/content/full/99/2/907
Organism mouse
Organ heart
Source Curated
CellType cardiomyocyte
MedLine Reference 10913625:3
CellLineName PC 12
Organism rat
Tissue nerve
Organ skin
Source Curated
MedLine Reference 9812990:1316
Journal J. Biol. Chem
Journal Reference v273 i47 p30945 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/47/30945
CellLineName CHO.T
Source Curated