ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:2998:out-urn:agi-llid:2932::negative
Entities GYS2 ---| GSK3B
References 10
Connectivity 2
Effect negative
MedLine Reference 12086949:1261
Sentence The progressive GS activation apparently involves downregulation of GSK-3 protein expression because total activity and protein expression were reduced to the same extent.
Journal Diabetes
Journal Reference v51 i7 p2190 (2002)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/7/2190
Tissue muscle
Source Curated
MedLine Reference 10567568:1351
Sentence Dephosphorylation of the GSK3 sites in both glycogen synthase and C/EBPalpha appears to be mediated by PP1, since both activities are sensitive to okadaic acid and wortmannin.
Journal Mol. Cell. Biol
Journal Reference v19 i12 p8433 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/12/8433
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 12525490:1081
Sentence Palmitate and stearate also inhibited insulin-stimulated phosphorylation of GSK3eta (Fig. 1 A ), a substrate of Akt/PKB with numerous functions including the regulation of glycogen synthase activity ( 44 ).
Journal J. Biol. Chem
Journal Reference v278 i12 p10297 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/12/10297
CellLineName C2C12
Organism mouse
Source Curated
CellType myotube
MedLine Reference 10318852:1284
Sentence Activation of glycogen synthase by insulin involves a coordinated response, including phosphorylation induced inactivation of glycogen synthase kinase 3 (GSK3 ) and activation of protein phosphatase 1, by phosphorylation of its G subunit (pp1G) ( 49 ).
Journal J. Biol. Chem
Journal Reference v274 i20 p14306 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/20/14306
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10346822:1023
Sentence Whereas it has been well established that glycogen synthase is dephosphorylated (activated) by protein phosphatase 1 (PP1) ( 7 ) and phosphorylated (inactivated) by glycogen synthase kinase 3 (GSK3) ( 36 ), the precise molecular mechanism by which insulin regulates this complex process is not well understood.
Journal Genes & Dev
Journal Reference v13 i10 p1342 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/10/1342
Organism drosophila
Source Curated
MedLine Reference 11289034:1212
Journal Diabetes
Journal Reference v50 i4 p720 (2001)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/50/4/720
Source Curated
CellType myoblast
MedLine Reference 9478990:1144
Journal J. Biol. Chem
Journal Reference v273 i9 p5315 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/9/5315
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 12950267:3
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 9603900:1112
Journal J. Biol. Chem
Journal Reference v273 i23 p14063 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/23/14063
CellLineName 3T3 L1
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 9312151:1029
Journal J. Biol. Chem
Journal Reference v272 i40 p25326 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/25326
Source Curated
CellType neural