Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:572:out-urn:agi-cellproc:apoptosis::positive
Entities BAD --+> apoptosis
References 20
Connectivity 2
MedLine Reference 9393984:5
Sentence Bak was barely detectable and Bad protein level decreased in cells undergoing apoptosis.
Organism mouse
Source Curated
CellType MAST
MedLine Reference 14646536:0
Sentence BAG-1 has been identified as a Bcl-2-binding protein that inhibits apoptosis, either alone or in co-operation with Bcl-2.
Source Curated
MedLine Reference 12714518:1218
Sentence Li et al 27 showed that Akt activation, which could lead to inactivation of proapoptotic Bad protein, prevented IL-3 withdrawal??????induced apoptosis in 32D cells.
Journal Blood
Journal Reference v102 i4 p1290 (2003)
Journal Link http://www.bloodjournal.org/cgi/content/full/102/4/1290
Organism mouse
Source Curated
CellLineName 32D
MedLine Reference 11559533:1108
Sentence Because Akt is known to phosphorylate and suppress the activity of the proapoptotic protein Bad, we also addressed the possibility that Akt contributed to GBM formation by effects on apoptosis (7) .
Journal Cancer Res
Journal Reference v61 i18 p6674 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/18/6674
Organism mouse
Source Curated
CellType astrocyte
MedLine Reference 9389536:1201
Sentence In addition to BAX ( 31 ), BAD is the second proapoptotic protein of the Bcl-2 family found to be expressed in ovarian granulosa cells, the cell type undergoing apoptosis during follicle atresia ( 23 ).
Tissue egg
Journal Endocrinology
Journal Reference v138 i12 p5497 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/138/12/5497
Organism rat
Source Curated
CellType granulosa
MedLine Reference 11289094:1230
Sentence Suppression of apoptosis by Bcr-Abl may be mediated by inducing the expression of the antiapoptotic protein, Bcl-2 (perhaps through Stat pathways), by phosphorylation of the proapoptotic protein Bad or through Ras-dependent pathways (176 , 195 , 227) .
Source Curated
Source Curated
CellType neural
MedLine Reference 15033904:1
Source Curated
MedLine Reference 10860979:1
Organism mouse
Source Curated
MedLine Reference 9843996:1153
Journal PNAS
Journal Reference v95 i25 p14950 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/25/14950
Source Curated
MedLine Reference 10051597:1136
Journal PNAS
Journal Reference v96 i5 p2077 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/5/2077
Source Curated
CellLineName cef
MedLine Reference 11490019:1036
Tissue smooth muscle
Journal J. Immunol
Journal Reference v167 i4 p2305 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/167/4/2305
Organ aorta
Organism rat
Source Curated
CellLineName C5
MedLine Reference 10779773:1245
Journal J. Immunol
Journal Reference v164 i9 p4678 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/9/4678
Organism mouse
Source Curated
CellType lymphocyte
MedLine Reference 10648553:1046
Journal J. Cell Biol
Journal Reference v148 i2 p223 (2000)
Journal Link http://www.jcb.org/cgi/content/full/148/2/223
Source Curated
CellType neural
MedLine Reference 9388232:1009
Journal J. Biol. Chem
Journal Reference v272 i49 p30866 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/49/30866
Organism mouse
Source Curated
MedLine Reference 10066754:1309
Journal J. Biol. Chem
Journal Reference v274 i11 p7002 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/11/7002
Source Curated
MedLine Reference 11356677:1037
Tissue egg
Journal Endocrinology
Journal Reference v142 i6 p2311 (2001)
Journal Link http://endo.endojournals.org/cgi/content/full/142/6/2311
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 11878929:2
Source Curated
MedLine Reference 10837473:0
Source Curated
MedLine Reference 12629169:1031
Source Curated