Protein : CASP10
Owner Public
URN urn:agi-llid:843
Hugo ID 1500
Connectivity 185
Name CASP10
Description caspase 10, apoptosis-related cysteine peptidase
Notes This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Pathway FAS signaling
Caspases
Mitochondrial control of Apoptosis
Death receptor signaling
Inhibition of Apoptosis
DR3 and DR4-5 pathways
Apoptosis
Copy of 'Apoptosis'
Apoptosis2
Group Proteases
regulation of apoptosis
induction of apoptosis
proteolysis
protein binding
identical protein binding
cysteine-type peptidase activity
caspase activity
GenBank ID NC_000002
NM_032974
NP_116756
NM_032977
NP_116759
NM_032976
NP_116758
NM_001230
NP_001221
NT_005403
NW_921618
AC_000045
AB038979
BAB32553
BAB32554
AC007283
AAY24291
AF111344
AAD28402
AF111345
AAD28403
AI696103
AJ487678
CAD32371
AJ487679
CAD32372
AY690601
AAU00989
BC042844
AAH42844
U60519
AAC50644
U86214
AAB46730
Q68HC0
Q6KF62
Q6KF63
Q8IUP5
Q92851
Source Curated
LocusLink ID 843
Organism Homo sapiens
OMIM ID 601762
603909
137215
605027
Alias MCH4
ALPS2
FLICE2
caspase 10
FADD-like ICE2
apoptotic protease MCH-4
ICE-like apoptotic protease 4
interleukin-1B-converting enzyme 2
Fas-associated death domain protein
caspase 10, apoptosis-related cysteine protease
GO ID 0030693
0008234
0042802
0005515
0006917
0006508
0042981
Swiss-Prot Accession Q68HC0
Q6KF62
Q6KF63
Q8IUP5
Q92851
Unigene ID Hs.5353