Protein : PDPK1
Owner Public
URN urn:agi-llid:5170
Hugo ID 8816
Connectivity 531
Name PDPK1
Description 3-phosphoinositide dependent protein kinase-1
Notes may catalyze the phosphorylation and activation of protein kinase B [RGD]
RGD ID 620307
MGI ID 1338068
Pathway Insulin Receptor Signaling
Antiapoptotic Pathways From IGF-1R
Mitochondrial control of Apoptosis
AKT signaling
Inhibition of Apoptosis
PTEN signaling
CREB signaling
Apoptosis
EDG2 -> ELK4-SRF signaling pathway
NOTCH1 -> NF-kB signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> MYCN signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
ERBB2 -> ETV4 signaling pathway
NTRKs -> FOXO1A signaling pathway
IGF1R -> CEBPA signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> FOXO3A signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
NTRKs -> TP53 signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> FOXO1A signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
IL12R -> NF-kB signaling pathway
IL12R -> NFATC1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
IL15R -> NF-kB signaling pathway
F2R -> NF-kB signaling pathway
PTAFR -> AP-1 signaling pathway
F2R -> SP1 signaling pathway
PTAFR -> ATF1 signaling pathway
IL15R -> NFATC2 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
PTAFR -> NF-kB signaling pathway
EPOR -> ELK4-SRF signaling pathway
EPOR -> FOS signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
EPOR -> NF-kB signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
CD19 -> NF-kB signaling pathway
IL7R -> FOXO1A signaling pathway
IL7R -> FOXO3A signaling pathway
IL7R -> NF-kB signaling pathway
TEK -> FOXO1A signaling pathway
INSR -> CTNNB1 signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
INSR -> FOXA2 signaling pathway
INSR -> FOXO1A signaling pathway
INSR -> FOXO3A signaling pathway
INSR -> FOXO6 signaling pathway
CD28 -> NF-kB signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
CD28 -> NFAT5 signaling pathway
ITGAM/ITGB2 -> CEBPB signaling pathway
CD28 -> NFATC1 signaling pathway
CD28 -> NFATC2 signaling pathway
CD28 -> NFATC3 signaling pathway
CD28 -> NFATC4 signaling pathway
FSHR -> FOXO1A signaling pathway
ITGAM/ITGB2 -> NF-kB signaling pathway
TLR1/2 -> NF-kB signaling pathway
ADORA1 -> NF-kB signaling pathway
ITGB1 -> CTNNB1 signaling pathway
ITGB1 -> NF-kB signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CTNNB1 signaling pathway
GFRs -> FOXO3A signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
TLR2/6 -> NF-kB signaling pathway
GFRs -> NCOR2 signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
GHR -> NF-kB signaling pathway
CNRs -> CREB1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
ADRB1 -> STAT3 signaling pathway
ADRB2 -> STAT3 signaling pathway
MPL -> SPI1 signaling pathway
ADRB3 -> STAT3 signaling pathway
DRD2 -> AP-1 signaling pathway
DRD2 -> CREB1 signaling pathway
ICAM2 -> CTNNB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGER -> NF-kB signaling pathway
ICAM2 -> FOXO1A signaling pathway
ICAM2 -> FOXO3A signaling pathway
ICAM2 -> MLLT7 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
DRD2 -> NF-kB signaling pathway
ICAM2 -> STAT3 signaling pathway
EDG2 -> ELK1-SRF signaling pathway
TNFRSF5/13B -> NFATC1 signaling pathway
Copy of 'Apoptosis'
Apoptosis2
AKT signaling2
Apoptosis2
tshirt 'Insulin Receptor Signaling' 3
Group Kinases
Ph
signal transduction
insulin receptor signaling pathway
actin cytoskeleton organization and biogenesis
protein amino acid phosphorylation
hyperosmotic response
membrane
cytoplasm
cytoplasmic membrane-bound vesicle
plasma membrane
nucleotide binding
ATP binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
3-phosphoinositide-dependent protein kinase activity
protein kinase activator activity
GenBank ID NC_000016
NM_002613
NP_002604
NM_031268
NP_112558
NT_037887
NW_926018
XM_939834
XP_944927
AC_000059
AC005591
AAC33797
AC093525
AC141586
AJ406809
CAC10873
AB209835
BAD93072
AF017995
AAC51825
AF111845
AAF16685
AK095507
AK131060
AK222581
BAD96301
AL157446
BC000789
BC006339
AAH06339
BC012103
AAH12103
BC012540
BC033494
AAH33494
BC040324
BI830733
CR536517
CAG38755
Y15056
CAA75341
O15530
Q53HJ9
Q59EH6
Q6FI20
Q9BRD5
Q9UI25
Q9UPJ7
Q9UPJ8
NC_000083
NM_011062
NP_035192
NT_039649
NW_000124
NW_001030605
AC_000039
AY162410
AAO17164
CT010502
AF079535
AAC96115
AF086625
AAC67544
AF126294
AAD38505
AK047229
AK147149
BAE27716
AK147835
BAE28171
AK149162
AK149289
BAE28793
AK162677
BAE37017
AK165564
AK188106
AK205439
AK215448
AK219503
AY062008
AAL47185
BQ174223
Q9Z2A0
NC_005109
NM_031081
NP_112343
NW_001084656
NW_047334
AC_000078
Y15748
CAA75758
O55173
Source Curated
LocusLink ID 5170
18607
81745
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 605213
Alias PDK1
PRO0461
MGC20087
MGC35290
PkB-like
PkB-like 1
3-phosphoinositide dependent protein kinase-1
PkB kinase
protein kinase
PkB kinase like gene 1
GO ID 0004676
0005524
0000166
0004672
0004674
0016740
0030036
0008286
0006468
0005737
0005886
0016301
0006972
0007165
0016023
0016020
0030295
Swiss-Prot Accession O15530
Q53HJ9
Q59EH6
Q6FI20
Q9BRD5
Q9UI25
Q9UPJ7
Q9UPJ8
Q9Z2A0
O55173
Unigene ID Hs.459691
Mm.10504
Rn.10905