Protein : STAT1
Owner Public
URN urn:agi-llid:6772
Hugo ID 11362
Connectivity 1300
Name STAT1
Description signal transducer and activator of transcription 1
Notes component of the IFN-gamma receptor signaling pathway and other signaling pathways; plays a role in development of cytokine resistance [RGD]
RGD ID 3771
MGI ID 103063
Cell Localization Nucleus
Pathway p38 MAPK
p40 MAPK
IL29
IFN beta
IL28B
IL28A
IL27
IFN alpha
IL21
Jak-Stat Pathway from IL6 Receptor
IL17A
EGF signaling
M-CSF
IL12
p38 Signaling
IL26
PDGF signaling
MAPK-ERK in Growth and Differentiation
Inhibition of Apoptosis
IL6
IL5
IL10
IL24
IL28
IFN gamma
IL23
EGF
MAPK signaling
AGTR1 -> STAT1 signaling pathway
IFNGR -> STAT1 signaling pathway
AGTR2 -> STAT1 signaling pathway
ALK -> STAT1 signaling pathway
EGFR/ERBB2 -> STAT1 signaling pathway
IGF1R -> STAT1 signaling pathway
IL10R -> STAT1 signaling pathway
PDGFRs -> STAT1 signaling pathway
IL12R -> STAT1 signaling pathway
PLAUR -> STAT1 signaling pathway
IL13R -> STAT1 signaling pathway
PRLR -> STAT1 signaling pathway
F2R -> STAT1 signaling pathway
IL15R -> STAT1 signaling pathway
EPOR -> STAT1 signaling pathway
CCKBR -> STAT1 signaling pathway
IL21R -> STAT1 signaling pathway
FGFR1 -> STAT1 signaling pathway
CCR1 -> STAT1 signaling pathway
IL2R -> STAT1 signaling pathway
CCR2 -> STAT1 signaling pathway
IL31R -> STAT1 signaling pathway
CCR5 -> STAT1 signaling pathway
FGFR3 -> STAT1 signaling pathway
IL3R -> STAT1 signaling pathway
IL5R -> STAT1 signaling pathway
CD2 -> STAT1 signaling pathway
IL6R -> STAT1 signaling pathway
IL7R -> STAT1 signaling pathway
IL9R -> STAT1 signaling pathway
INSR -> STAT1 signaling pathway
CD28 -> STAT1 signaling pathway
CD4 -> STAT1 signaling pathway
KDR -> STAT1 signaling pathway
KIT -> STAT1 signaling pathway
ADRA1B -> STAT1 signaling pathway
GHR -> STAT1 signaling pathway
LEPR -> STAT1 signaling pathway
CSF1R -> STAT1 signaling pathway
CSF2R -> STAT1 signaling pathway
MET -> STAT1 signaling pathway
CSF3R -> STAT1 signaling pathway
CXCR4 -> STAT1 signaling pathway
MPL -> STAT1 signaling pathway
TNFRSF1A -> STAT1 signaling pathway
IFNAR -> STAT1 signaling pathway
p38 Signaling2
Group Sh2
Transcription factors
signal transduction
intracellular signaling cascade
I-kappaB kinase-NF-kappaB cascade
JAK-STAT cascade
STAT protein nuclear translocation
tyrosine phosphorylation of STAT protein
regulation of progression through cell cycle
caspase activation
transcription
regulation of transcription, DNA-dependent
transcription from RNA polymerase II promoter
response to virus
cytoplasm
nucleus
signal transducer activity
protein binding
calcium ion binding
DNA binding
transcription factor activity
hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity
GenBank ID NC_000002
NM_007315
NP_009330
NM_139266
NP_644671
NT_005403
NW_921585
AC_000045
AC067945
AAY24183
AF182311
AY366464
AAR13284
AY865620
AAW56072
U18662
U18663
U18664
U18665
U18666
U18667
U18668
U18669
U18670
AK096686
BC002704
AAH02704
BG699050
BT007241
AAP35905
CR601119
CR618286
CR749636
CAH18430
M97935
AAB64012
M97936
P42224
Q53S88
Q53XW4
Q67C41
Q68D00
Q9UDL5
NC_000067
NM_009283
NP_033309
NT_039170
NW_000166
NW_001030680
AC_000023
AC123752
AF349678
AAK48844
U80267
AA960121
AK008127
AK018544
BAB31265
AK039458
BAC30355
AK041599
BAE43313
AK041814
BAE43314
AK046517
BAC32766
AK082706
BAC38579
AK084855
BAC39293
AK088874
AK157263
BAE34017
AK157458
AK159887
BAE35456
AW214029
BC004808
AAH04808
BC042551
AAH42551
BC057690
AAH57690
BM239586
U06924
AAA19454
U92116
AAC02821
P42225
Q8CFQ1
NC_005108
NM_032612
NP_116001
NM_001034164
NP_001029336
NW_001084882
NW_047815
AC_000077
AABR03068246
AF053767
AAC08438
AF205604
AAF20200
BC062079
AAH62079
CV075250
O70406
Source Curated
LocusLink ID 6772
20846
25124
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600555
209950
Alias ISGF-3
STAT91
DKFZp686B04100
signal transducer and activator of transcription 1
transcription factor ISGF-3
transcription factor ISGF-3 components p91/p84
signal transducer and activator of transcription-1
AA408197
2010005J02Rik
GO ID 0005509
0005062
0005515
0004871
0003700
0007249
0007262
0006919
0007242
0000074
0006355
0009615
0006350
0006366
0007260
0005737
0005634
0003677
0007165
0007259
Swiss-Prot Accession P42224
Q53S88
Q53XW4
Q67C41
Q68D00
Q9UDL5
P42225
Q8CFQ1
O70406
Unigene ID Hs.470943
Mm.277406
Rn.33229