DirectRegulation :

Owner Public
URN urn:agi-DirectRegulation:inout-urn:agi-llid:843:out-urn:agi-llid:839::positive
Entities CASP10 --+> CASP6
References 3
Effect positive
Connectivity 2
Sentence After being activated, "initiator" caspases 8, 9, and 10 can cleave and activate "effector" caspases 3, 7, and 6 (21) .
Journal Cancer Res
Source Curated
Journal Reference v61 i6 p2713 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/6/2713
MedLine Reference 11289152:1045
Sentence The other short prodomain caspases including caspase-3, -6, and -7 associated only with caspase-10 (data not shown).
Journal J. Biol. Chem
Source Curated
Journal Reference v273 i45 p29648 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/45/29648
Organism mouse
Tissue egg
MedLine Reference 9792675:1084
Sentence Initiator caspases (e.g., caspases-8, -9, and -10) activate downstream effector caspases (e.g., caspases-3, -6, and -7), which in turn cleave specific cellular targets, resulting in cell death ( Thornberry and Lazebnik, 1998 ).
Journal J. Cell Biol
Source Curated
Journal Reference v154 i6 p1111 (2001)
Journal Link http://www.jcb.org/cgi/content/full/154/6/1111
MedLine Reference 11551979:1024