Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:5170:inout-urn:agi-complex:3000112:
Entities PDPK1 ---- Phosphatidylinositol 3-kinase
References 10
MedLine Reference 11035106:1248
Sentence These experiments suggest that LPS activates PKC via activation of PI 3-kinase and PKC /PDK-1 complex formation.
Tissue alveola
CellType macrophage
Journal J. Immunol
Journal Reference v165 i8 p4632 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/8/4632
Source Curated
MedLine Reference 11060301:1227
Sentence Recent reports have shown that PDK-1 also binds with high affinity to the PI 3-kinase lipid product phosphatidylinositol 3,4,5-triphosphate (PtdIns-3,4,5-P 3 ) ( 18 ).
Journal J. Biol. Chem
Journal Reference v276 i4 p2395 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/4/2395
Source Curated
MedLine Reference 11254732:1028
Sentence PDK-1 is recruited to PI 3-kinase-phosphorylated lipids (PI 3,4,5 P) by its pleckstrin homology (PH) domain.
Organ lung
Tissue alveola
CellType macrophage
Journal J. Immunol
Journal Reference v166 i7 p4713 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/7/4713
Source Curated
MedLine Reference 10662827:1329
Sentence The regulation of PKCeta by PI3'-kinase may occur via the phosphoinositide-dependent protein kinase-1 (PDK-1), which binds with high affinity to the PI3'-kinase lipid product phosphatidylinositol-3,4,5-trisphosphate.
Journal J. Neurosci
Journal Reference v20 i4 p1365 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/4/1365
Source Curated
CellLineName PF
MedLine Reference 10383403:1420
Sentence Two reports show that the phosphoinositide-dependent protein kinase 1 (PDK-1 ), which binds with high affinity to the PI 3-kinase lipid product phosphatidylinositol 3,4,5-trisphosphate, phosphorylates and potently activates PKC eta along with two other substrates, also kinases, Akt/PKB and p70S6K.
Journal J. Biol. Chem
Journal Reference v274 i27 p19025 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/27/19025
Organism mouse
Source Curated
MedLine Reference 9768361:2
Organism mouse
Source Curated
MedLine Reference 10523666:1330
CellType adipocyte
Journal Mol. Cell. Biol
Journal Reference v19 i11 p7771 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/11/7771
Organism mouse
Source Curated
MedLine Reference 10946268:1260
CellType t cell
Journal J. Immunol
Journal Reference v165 i5 p2432 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/5/2432
Organism mouse
Source Curated
MedLine Reference 10438924:1051
Journal J. Immunol
Journal Reference v163 i4 p1894 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/4/1894
Organism mouse
Source Curated
MedLine Reference 12525490:1036
Tissue fat
Journal J. Biol. Chem
Journal Reference v278 i12 p10297 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/12/10297
Organism mouse
Source Curated